Charani Ranasinghe

Matrix assisted laser desorption ionisation time of flight mass spectrometry (MALDI-TOF MS) for detecting novel Bt toxins.

Development of a synthetic consensus sequence scrambled antigen HIV-1 vaccine designed for global use.

Mucosally-administered human-simian immunodeficiency virus DNA and fowlpoxvirus-based recombinant vaccines reduce acute phase viral replication in macaques following vaginal challenge with CCR5-tropic SHIVSF162P3.

Evaluation of fowlpox-vaccinia virus prime-boost vaccine strategies for high-level mucosal and systemic immunity against HIV-1.

Prime-boost strategies in DNA vaccines.

4-1BBL coexpression enhances HIV-specific CD8 T cell memory in a poxvirus prime-boost vaccine.

Mucosal HIV-1 pox virus prime-boost immunization induces high-avidity CD8+ T cells with regime-dependent cytokine/granzyme B profiles.

Differential effects of the type I interferons alpha4, beta, and epsilon on antiviral activity and vaccine efficacy.

Immunisation route-dependent expression of IL-4/IL-13 can modulate HIV-specific CD8(+) CTL avidity.

Genetic heterologous prime-boost vaccination strategies for improved systemic and mucosal immunity.

Human immunodeficiency virus-1 vaccine design: where do we go now?

Evaluating vaccinia virus cytokine co-expression in TLR GKO mice.

A comparative analysis of HIV-specific mucosal/systemic T cell immunity and avidity following rDNA/rFPV and poxvirus-poxvirus prime boost immunisations.

Role of novel type I interferon epsilon in viral infection and mucosal immunity.

Fluorescent target array killing assay: a multiplex cytotoxic T-cell assay to measure detailed T-cell antigen specificity and avidity in vivo.

Fluorescent target array T helper assay: a multiplex flow cytometry assay to measure antigen-specific CD4+ T cell-mediated B cell help in vivo.

Reduced interleukin-4 receptor α expression on CD8+ T cells correlates with higher quality anti-viral immunity.

CCR6 is transiently upregulated on B cells after activation and modulates the germinal center reaction in the mouse.

IL-4 and IL-13 mediated down-regulation of CD8 expression levels can dampen anti-viral CD8⁺ T cell avidity following HIV-1 recombinant pox viral vaccination.

New advances in mucosal vaccination.

Progresses in DNA-based heterologous prime-boost immunization strategies.