David C. Irwin

Neutral endopeptidase null mice are less susceptible to high altitude-induced pulmonary vascular leak.

Pulmonary edema induced by cerebral hypoxic insult in a canine model.

Polymerized bovine hemoglobin decreases oxygen delivery during normoxia and acute hypoxia in the rat.

A potential role for reactive oxygen species and the HIF-1alpha-VEGF pathway in hypoxia-induced pulmonary vascular leak.

Glutaraldehyde-polymerized bovine hemoglobin and phosphodiesterase-5 inhibition.

Cardiac HDAC6 catalytic activity is induced in response to chronic hypertension.

Selective class I histone deacetylase inhibition suppresses hypoxia-induced cardiopulmonary remodeling through an antiproliferative mechanism.

Free hemoglobin induction of pulmonary vascular disease: evidence for an inflammatory mechanism.

Upregulation of phase II enzymes through phytochemical activation of Nrf2 protects cardiomyocytes against oxidant stress.

Hemoglobin-induced endothelial cell permeability is controlled, in part, via a myeloid differentiation primary response gene-88-dependent signaling mechanism.

Nrf2 activation: a potential strategy for the prevention of acute mountain sickness.

Aberrant chloride intracellular channel 4 expression contributes to endothelial dysfunction in pulmonary arterial hypertension.

Selective depletion of vascular EC-SOD augments chronic hypoxic pulmonary hypertension.