Nicholas J. Harmer
Department of Biosciences
University of Exeter
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A tyrosine703serine polymorphism of CD109 defines the Gov platelet alloantigens.
Blood Mar, 2002 | Pubmed ID: 11861285
The structural biology of growth factor receptor activation.
Biophysical chemistry , 2003 | Pubmed ID: 12646390
The crystal structure of fibroblast growth factor (FGF) 19 reveals novel features of the FGF family and offers a structural basis for its unusual receptor affinity.
Biochemistry Jan, 2004 | Pubmed ID: 14730967
Towards a resolution of the stoichiometry of the fibroblast growth factor (FGF)-FGF receptor-heparin complex.
Journal of molecular biology Jun, 2004 | Pubmed ID: 15165853
1.15 A crystal structure of the X. tropicalis Spred1 EVH1 domain suggests a fourth distinct peptide-binding mechanism within the EVH1 family.
FEBS letters Feb, 2005 | Pubmed ID: 15710406
Cooperative dimerization of fibroblast growth factor 1 (FGF1) upon a single heparin saccharide may drive the formation of 2:2:1 FGF1.FGFR2c.heparin ternary complexes.
The Journal of biological chemistry Dec, 2005 | Pubmed ID: 16219767
Multimers of the fibroblast growth factor (FGF)-FGF receptor-saccharide complex are formed on long oligomers of heparin.
The Biochemical journal Feb, 2006 | Pubmed ID: 16223363
Structural biology and bioinformatics in drug design: opportunities and challenges for target identification and lead discovery.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences Mar, 2006 | Pubmed ID: 16524830
Expression and purification of recombinant human fibroblast growth factor receptor in Escherichia coli.
Protein expression and purification Sep, 2006 | Pubmed ID: 16750394
Cloning, expression, purification and preliminary crystallographic analysis of the short-chain dehydrogenase enzymes WbmF, WbmG and WbmH from Bordetella bronchiseptica.
Acta crystallographica. Section F, Structural biology and crystallization communications Aug, 2007 | Pubmed ID: 17671375
Predicting protein function from structure--the roles of short-chain dehydrogenase/reductase enzymes in Bordetella O-antigen biosynthesis.
Journal of molecular biology Nov, 2007 | Pubmed ID: 17950751
Evidence that heparin saccharides promote FGF2 mitogenesis through two distinct mechanisms.
The Journal of biological chemistry May, 2008 | Pubmed ID: 18281281
The structure of sedoheptulose-7-phosphate isomerase from Burkholderia pseudomallei reveals a zinc binding site at the heart of the active site.
Journal of molecular biology Jul, 2010 | Pubmed ID: 20447408
The structure of a Burkholderia pseudomallei immunophilin-inhibitor complex reveals new approaches to antimicrobial development.
The Biochemical journal Aug, 2011 | Pubmed ID: 21574961
A novel FK-506-binding-like protein that lacks peptidyl-prolyl isomerase activity is involved in intracellular infection and in vivo virulence of Burkholderia pseudomallei.
Microbiology (Reading, England) Sep, 2011 | Pubmed ID: 21680634
A Burkholderia pseudomallei macrophage infectivity potentiator-like protein has rapamycin-inhibitable peptidylprolyl isomerase activity and pleiotropic effects on virulence.
Infection and immunity Nov, 2011 | Pubmed ID: 21859853
Myosin-5, kinesin-1 and myosin-17 cooperate in secretion of fungal chitin synthase.
The EMBO journal Jan, 2012 | Pubmed ID: 22027862
A structural biology approach enables the development of antimicrobials targeting bacterial immunophilins.
Antimicrobial agents and chemotherapy , 2014 | Pubmed ID: 24366729
Structural insights into WcbI, a novel polysaccharide-biosynthesis enzyme.
IUCrJ Jan, 2014 | Pubmed ID: 25075317
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