Akira Sawa

Elucidating the relationship between DISC1, NDEL1 and NDE1 and the risk for schizophrenia: evidence of epistasis and competitive binding.

Nitric oxide-induced nuclear GAPDH activates p300/CBP and mediates apoptosis.

Recruitment of PCM1 to the centrosome by the cooperative action of DISC1 and BBS4: a candidate for psychiatric illnesses.

Proteomic and histochemical analysis of proteins involved in the dying-back-type of axonal degeneration in the gracile axonal dystrophy (gad) mouse.

Peripheral olfactory system for clinical and basic psychiatry: a promising entry point to the mystery of brain mechanism and biomarker identification in schizophrenia.

Schizophrenia and epilepsy: is there a shared susceptibility?

Animal models of gene-environment interactions in schizophrenia.

GOSPEL: a neuroprotective protein that binds to GAPDH upon S-nitrosylation.

Using bioinformatic tools.

Cortical development and glutamatergic dysregulation in schizophrenia.

Neurodevelopmental mechanisms of schizophrenia: understanding disturbed postnatal brain maturation through neuregulin-1-ErbB4 and DISC1.

Combined effect of neonatal immune activation and mutant DISC1 on phenotypic changes in adulthood.

A novel role for hGas7b in microtubular maintenance: possible implication in tau-associated pathology in Alzheimer disease.

Negative symptoms of schizophrenia correlate with impairment on the University of Pennsylvania smell identification test.

Understanding the role of DISC1 in psychiatric disease and during normal development.

Glyceraldehyde-3-phosphate dehydrogenase aggregate formation participates in oxidative stress-induced cell death.

Review of pathological hallmarks of schizophrenia: comparison of genetic models with patients and nongenetic models.

Preface. This volume focuses on how genetic models for schizophrenia, that is, manipulation in genetic susceptibility factors for the disease, have potential in opening a new window of better understanding of etiology-relevant mechanisms.

A novel role for glyceraldehyde-3-phosphate dehydrogenase and monoamine oxidase B cascade in ethanol-induced cellular damage.

Disrupted-in-Schizophrenia 1 (DISC1) regulates spines of the glutamate synapse via Rac1.

Neuroanatomic and cognitive abnormalities related to herpes simplex virus type 1 in schizophrenia.

Knockdown of DISC1 by in utero gene transfer disturbs postnatal dopaminergic maturation in the frontal cortex and leads to adult behavioral deficits.

Disrupted-in-Schizophrenia-1 expression is regulated by beta-site amyloid precursor protein cleaving enzyme-1-neuregulin cascade.

Genetic animal models for schizophrenia: advantages and limitations of genetic manipulation in drosophila, zebrafish, rodents, and primates.

Disturbed synaptic connectivity in schizophrenia: convergence of genetic risk factors during neurodevelopment.

Gray-matter abnormalities in deficit schizophrenia.

Assessing the role of endooligopeptidase activity of Ndel1 (nuclear-distribution gene E homolog like-1) in neurite outgrowth.

Biochemical and functional interaction of disrupted-in-schizophrenia 1 and amyloid precursor protein regulates neuronal migration during mammalian cortical development.

The diverse functions of GAPDH: views from different subcellular compartments.

Nitric oxide signaling and nitrosative stress in neurons: role for S-nitrosylation.

A novel balanced chromosomal translocation found in subjects with schizophrenia and schizotypal personality disorder: altered l-serine level associated with disruption of PSAT1 gene expression.

Prenatal interaction of mutant DISC1 and immune activation produces adult psychopathology.

Impaired NMDA receptor transmission alters striatal synapses and DISC1 protein in an age-dependent manner.

DISC1-dependent switch from progenitor proliferation to migration in the developing cortex.

Working memory deficits in neuronal nitric oxide synthase knockout mice: potential impairments in prefrontal cortex mediated cognitive function.

Glutathione is a physiologic reservoir of neuronal glutamate.

In utero electroporation as a tool for genetic manipulation in vivo to study psychiatric disorders: from genes to circuits and behaviors.

Inositol hexakisphosphate kinases induce cell death in Huntington disease.

Readdressing synaptic pruning theory for schizophrenia: Combination of brain imaging and cell biology.

DISC1 regulates synaptic vesicle transport via a lithium-sensitive pathway.

Mouse strain differences in phencyclidine-induced behavioural changes.

Altered MHC class I expression in dorsolateral prefrontal cortex of nonsmoker patients with schizophrenia.

Protein S-nitrosylation: role for nitric oxide signaling in neuronal death.

Effects of antipsychotics on the behavioral deficits in human dominant-negative DISC1 transgenic mice with neonatal polyI:C treatment.

The insula-claustrum region and delusions in schizophrenia.

Better understanding of mechanisms of schizophrenia and bipolar disorder: from human gene expression profiles to mouse models.

Human nasal olfactory epithelium as a dynamic marker for CNS therapy development.

DISC1 at 10: connecting psychiatric genetics and neuroscience.

Advancing drug discovery for schizophrenia.

Following the genes: a framework for animal modeling of psychiatric disorders.

Linking neurodevelopmental and synaptic theories of mental illness through DISC1.

Anti-/Propsychotic drug signaling via heteromeric GPCRs--a balancing act?

Glucocorticoid-induced loss of DNA methylation in non-neuronal cells and potential involvement of DNMT1 in epigenetic regulation of Fkbp5.

KCTD13 is a major driver of mirrored neuroanatomical phenotypes of the 16p11.2 copy number variant.

Proteomic, genomic and translational approaches identify CRMP1 for a role in schizophrenia and its underlying traits.

Pharmacokinetics of oral D-serine in D-amino acid oxidase knockout mice.

PKA and PDE4D3 anchoring to AKAP9 provides distinct regulation of cAMP signals at the centrosome.

Diabetes is associated with lower global cognitive function in schizophrenia.

DISC1 as a therapeutic target for mental illnesses.

DISC1: a key lead in studying cortical development and associated brain disorders.

Subcortical dopaminergic deficits in a DISC1 mutant model: a study in direct reference to human molecular brain imaging.

Adolescent stress-induced epigenetic control of dopaminergic neurons via glucocorticoids.

Synapse-specific contributions in the cortical pathology of schizophrenia.

Schizophrenia research in 2013: are we making progress?

Astroglial IFITM3 mediates neuronal impairments following neonatal immune challenge in mice.

MicroRNA-382 expression is elevated in the olfactory neuroepithelium of schizophrenia patients.

Mouse models of gene-environment interactions in schizophrenia.

Cognitive and motivational deficits together with prefrontal oxidative stress in a mouse model for neuropsychiatric illness.

Cuprizone short-term exposure: astrocytic IL-6 activation and behavioral changes relevant to psychosis.

Relationships between serum leptin level and severity of positive symptoms in schizophrenia.

Regulation of N-Methyl-D-Aspartate Receptors by Disrupted-in-Schizophrenia-1.

Reduced anterior cingulate gray matter volume and thickness in subjects with deficit schizophrenia.

Deficits in microRNA-mediated Cxcr4/Cxcl12 signaling in neurodevelopmental deficits in a 22q11 deletion syndrome mouse model.

Olfactory cells via nasal biopsy reflect the developing brain in gene expression profiles: utility and limitation of the surrogate tissues in research for brain disorders.

Hippocampal volume reduction correlates with apathy in traumatic brain injury, but not schizophrenia.

Modeling heterogeneous patients with a clinical diagnosis of schizophrenia with induced pluripotent stem cells.

Promoting careers in academic research to psychiatry residents.

Regional brain distribution of translocator protein using [(11)C]DPA-713 PET in individuals infected with HIV.

Oxidative stress and schizophrenia: recent breakthroughs from an old story.

PAKs inhibitors ameliorate schizophrenia-associated dendritic spine deterioration in vitro and in vivo during late adolescence.

Reasons for not seeking general medical care among individuals with serious mental illness.

Inflammatory molecular signature associated with infectious agents in psychosis.

Human stem cells and surrogate tissues for basic and translational study of mental disorders.

Neuropeptide precursor VGF is genetically associated with social anhedonia and underrepresented in the brain of major mental illness: its downregulation by DISC1.

Is prophylactic psychiatry around the corner? combating adolescent oxidative stress for adult psychosis and schizophrenia.

Role of Apoptosis Signal-regulating Kinase 1 (ASK1) as an activator of the GAPDH-Siah1 Stress-Signaling Cascade.

Environmental Stresso, rs and Epigenetic Control of the Hypothalamic-Pituitary-Adrenal-Axis (HPA-axis).