Sibylle Mittnacht

p16INK4a loss and sensitivity in KSHV associated primary effusion lymphoma.

RB activation defect in tumor cell lines.

Crystal structure of the retinoblastoma tumor suppressor protein bound to E2F and the molecular basis of its regulation.

High-throughput screening for the identification of small-molecule inhibitors of retinoblastoma protein phosphorylation in cells.

A novel constitutional mutation affecting splicing of retinoblastoma tumor suppressor gene intron 23 causes partial loss of pRB activity.

The retinoblastoma protein--from bench to bedside.

Selective ablation of retinoblastoma protein function by the RET finger protein.

Regulation of microfilament organization by Kaposi sarcoma-associated herpes virus-cyclin.CDK6 phosphorylation of caldesmon.

Direct interaction between the catalytic subunit of Protein Phosphatase 1 and pRb.

Trans-activation of the DNA-damage signalling protein kinase Chk2 by T-loop exchange.

Attenuation of disease phenotype through alternative translation initiation in low-penetrance retinoblastoma.

Crystal structure of the retinoblastoma protein N domain provides insight into tumor suppression, ligand interaction, and holoprotein architecture.

p53-Driven apoptosis limits centrosome amplification and genomic instability downstream of NPM1 phosphorylation.

Nonsense-mediated decay: paving the road for genome diversification.

Cyclin-cyclin-dependent kinase regulatory response is linked to substrate recognition.

Mechanism-based screen for G1/S checkpoint activators identifies a selective activator of EIF2AK3/PERK signalling.

Mechanism-based screen establishes signalling framework for DNA damage-associated G1 checkpoint response.

Role of the tripartite motif protein 27 in cancer development.

Structural insights into the mechanism of phosphoregulation of the retinoblastoma protein.