Aurel Perren

Loss of heterozygosity at chromosome 6q23-25 correlates with clinical and histologic parameters in salivary gland adenoid cystic carcinoma.

Absence of somatic SDHD mutations in sporadic neuroendocrine tumors and detection of two germline variants in paraganglioma patients.

Secretory apparatus assessed by analysis of pancreatic secretory stress protein expression in a rat model of chronic pancreatitis.

Morphologic changes and altered gene expression in an epithelioid hemangioendothelioma during a ten-year course of disease.

Lymph node surgery in papillary thyroid carcinoma.

DPC4/Smad4: no mutations, rare allelic imbalances, and retained protein expression in pancreatic endocrine tumors.

A novel succinate dehydrogenase subunit B gene mutation, H132P, causes familial malignant sympathetic extraadrenal paragangliomas.

Coordinate regulation of PSP/reg and PAP isoforms as a family of secretory stress proteins in an animal model of chronic pancreatitis.

The gastroenteropancreatic neuroendocrine cell system and its tumors: the WHO classification.

Molecular genetics of gastroenteropancreatic endocrine tumors.

Absence of BRAF gene mutations differentiates spitz nevi from malignant melanoma.

Abnormalities of proinsulin processing in functioning insulinomas: clinical implications.

Persistent hyperinsulinemic hypoglycemia in 15 adults with diffuse nesidioblastosis: diagnostic criteria, incidence, and characterization of beta-cell changes.

Precursor lesions in patients with multiple endocrine neoplasia type 1-associated duodenal gastrinomas.

Caseous calcification of the mitral annulus.

Assessment of Helicobacter pylori clarithromycin resistance mutations in archival gastric biopsy samples.

Fatal esophageal perforation caused by invasive candidiasis.

Exocrine meets endocrine: pancreatic stone protein and regenerating protein--two sides of the same coin.

Microadenomatosis of the endocrine pancreas in patients with and without the multiple endocrine neoplasia type 1 syndrome.

Pancreatic endocrine tumors are a rare manifestation of the neurofibromatosis type 1 phenotype: molecular analysis of a malignant insulinoma in a NF-1 patient.

Sporadic versus hereditary gastrinomas of the duodenum and pancreas: distinct clinico-pathological and epidemiological features.

Multiple endocrine neoplasia type 1 (MEN1): loss of one MEN1 allele in tumors and monohormonal endocrine cell clusters but not in islet hyperplasia of the pancreas.

Hypoglycemia due to paraneoplastic secretion of insulin-like growth factor-I in a patient with metastasizing large-cell carcinoma of the lung.

Recurrent hypoglycaemia in HIV-positive narcotic addicts.

Gastrinoma (duodenal and pancreatic).

Superiority of small islets in human islet transplantation.

Familial pheochromocytomas and paragangliomas: stories from the sign-out room.

Increased number of islet-associated macrophages in type 2 diabetes.

Carcinogenic hypergastrinemia: signet-ring cell carcinoma in a patient with multiple endocrine neoplasia type 1 with Zollinger-Ellison's syndrome.

Candidate gene mutation analysis in bilateral adrenal pheochromocytoma and sympathetic paraganglioma.

CK19 and CD99 immunoexpression profile in goblet cell (mucin-producing neuroendocrine tumors) and classical carcinoids of the vermiform appendix.

Cytokeratins 7 and 20 immunoexpression profile in goblet cell and classical carcinoids of appendix.

Site-specific biology and pathology of gastroenteropancreatic neuroendocrine tumors.

Hereditary neuroendocrine tumors of the gastroenteropancreatic system.

Molecular profiles of gastroenteropancreatic endocrine tumors.

Endocrine precursor lesions and microadenomas of the duodenum and pancreas with and without MEN1: criteria, molecular concepts and clinical significance.

Endocrine precursor lesions of gastroenteropancreatic neuroendocrine tumors.

WHO 2004 criteria and CK19 are reliable prognostic markers in pancreatic endocrine tumors.

Adult diffuse nesidioblastosis: genetically or environmentally induced?

Consensus guidelines for the management of patients with liver metastases from digestive (neuro)endocrine tumors: foregut, midgut, hindgut, and unknown primary.

Islet inflammation in type 2 diabetes: from metabolic stress to therapy.

Islet 1 (Isl1) expression is a reliable marker for pancreatic endocrine tumors and their metastases.

Somatostatin-producing neuroendocrine tumors of the duodenum and pancreas: incidence, types, biological behavior, association with inherited syndromes, and functional activity.

Primary lymph node gastrinoma or occult duodenal microgastrinoma with lymph node metastases in a MEN1 patient: the need for a systematic search for the primary tumor.

Correlation of matrix metalloproteinases and tissue inhibitors of matrix metalloproteinase expression in ileal carcinoids, lymph nodes and liver metastasis with prognosis and survival.

Correlation of immunohistopathological expression of somatostatin receptor 2 with standardised uptake values in 68Ga-DOTATOC PET/CT.

Glucagon cell adenomatosis: a newly recognized disease of the endocrine pancreas.

Insulinomatosis: a multicentric insulinoma disease that frequently causes early recurrent hyperinsulinemic hypoglycemia.

ENETS Consensus Guidelines for the Standards of Care in Neuroendocrine Tumors: towards a standardized approach to the diagnosis of gastroenteropancreatic neuroendocrine tumors and their prognostic stratification.

Novel multiple, monoallelic KRAS mutations at codon 12 and 13.

An immunohistochemical procedure to detect patients with paraganglioma and phaeochromocytoma with germline SDHB, SDHC, or SDHD gene mutations: a retrospective and prospective analysis.

Vascular endothelial growth factors, angiogenesis, and survival in human ileal enterochromaffin cell carcinoids.

Anti insulin-like growth factor I receptor immunoliposomes: a single formulation combining two anticancer treatments with enhanced therapeutic efficiency.

Hyperglycaemia but not hyperlipidaemia decreases serum amylase and increases neutrophils in the exocrine pancreas of cats.

The ENETS and AJCC/UICC TNM classifications of the neuroendocrine tumors of the gastrointestinal tract and the pancreas: a statement.

VHL-gene deletion in single renal tubular epithelial cells and renal tubular cysts: further evidence for a cyst-dependent progression pathway of clear cell renal carcinoma in von Hippel-Lindau disease.

ENETS consensus guidelines for the management of brain, cardiac and ovarian metastases from neuroendocrine tumors.

Multicentre validation study of nucleic acids extraction from FFPE tissues.

SDHB loss predicts malignancy in pheochromocytomas/sympathethic paragangliomas, but not through hypoxia signalling.

[Pathology of malignant lymphomas--clarity instead of confusion].

Pheochromocytoma in rats with multiple endocrine neoplasia (MENX) shares gene expression patterns with human pheochromocytoma.

Clinical aspects, diagnostic challenges and management of patients with neuroendocrine tumors (NETs).

Impact of CD39 and purinergic signalling on the growth and metastasis of colorectal cancer.

Glucagon-like peptide-1 versus somatostatin receptor targeting reveals 2 distinct forms of malignant insulinomas.

The Ras inhibitors caveolin-1 and docking protein 1 activate peroxisome proliferator-activated receptor γ through spatial relocalization at helix 7 of its ligand-binding domain.

Serotonin-producing enterochromaffin cell tumors of the pancreas: clinicopathologic study of 15 cases and comparison with intestinal enterochromaffin cell tumors.

Are biochemical markers of neuroendocrine tumors coreleased with insulin following local calcium stimulation in patients with insulinomas?

Hormonally defined pancreatic and duodenal neuroendocrine tumors differ in their transcription factor signatures: expression of ISL1, PDX1, NGN3, and CDX2.

Functional Imaging of Pheochromocytoma with Ga-DOTATOC and C-HED in a Genetically Defined Rat Model of Multiple Endocrine Neoplasia.

Deletions of 11q22.3-q25 are associated with atypical lung carcinoids and poor clinical outcome.

Better provenance for biobank samples.

Sclerosing angiomatoid nodular transformation of the spleen presenting as a rapidly growing tumour in a patient with rectal cancer.

Poorly differentiated thyroid carcinomas: how much poorly differentiated is needed?

Malignant pheochromocytomas and paragangliomas: a diagnostic challenge.

Somatostatin receptor subtype 2A immunohistochemistry using a new monoclonal antibody selects tumors suitable for in vivo somatostatin receptor targeting.

ENETS Consensus Guidelines for the management of patients with neuroendocrine neoplasms from the jejuno-ileum and the appendix including goblet cell carcinomas.

Atypical presentation of a hormonally active adrenocortical tumor in an adolescent leading to delayed diagnosis.

Poorly differentiated oncocytic thyroid carcinoma--diagnostic implications and outcome.

Lymphotoxin β Receptor Signaling Promotes Development of Autoimmune Pancreatitis.

MicroRNA expression array identifies novel diagnostic markers for conventional and oncocytic follicular thyroid carcinomas.

Comprehensive MicroRNA expression profiling identifies novel markers in follicular variant of papillary thyroid carcinoma.

ISL1 expression is not restricted to pancreatic well-differentiated neuroendocrine neoplasms, but is also commonly found in well and poorly differentiated neuroendocrine neoplasms of extrapancreatic origin.

Next-generation tissue microarray (ngTMA) increases the quality of biomarker studies: an example using CD3, CD8, and CD45RO in the tumor microenvironment of six different solid tumor types.

Evaluation of the Hepa Wash® treatment in pigs with acute liver failure.

Diagnostic and prognostic implications of the PAX8-PPARγ translocation in thyroid carcinomas-a TMA-based study of 226 cases.

Determination of the molecular subtypes of diffuse large B-cell lymphomas using immunohistochemistry: a case series from the Inselspital, Bern, and a critical appraisal of this determination in Switzerland.

Intraductal papillary neoplasms of the bile duct: stepwise progression to carcinoma involves common molecular pathways.

CCND1/CyclinD1 status in metastasizing bladder cancer: a prognosticator and predictor of chemotherapeutic response.

ATG5 is induced by DNA-damaging agents and promotes mitotic catastrophe independent of autophagy.

Loss of DAXX and ATRX are associated with chromosome instability and reduced survival of patients with pancreatic neuroendocrine tumors.

MEN1 gene mutation and reduced expression are associated with poor prognosis in pulmonary carcinoids.

Loss of Raf-1 kinase inhibitor protein (RKIP) is strongly associated with high-grade tumor budding and correlates with an aggressive phenotype in pancreatic ductal adenocarcinoma (PDAC).

MicroRNA profile of poorly differentiated thyroid carcinomas: new diagnostic and prognostic insights.

Tumor regression grade of urothelial bladder cancer after neoadjuvant chemotherapy: a novel and successful strategy to predict survival.

Diagnosis and interdisciplinary treatment of a botryoid odontogenic cyst in the posterior mandible: report of a case.

Glucagon-like peptide-1 receptor imaging for the localisation of insulinomas: a prospective multicentre imaging study.

Hyperplasia to neoplasia sequence of duodenal and pancreatic neuroendocrine diseases and pseudohyperplasia of the PP-cells in the pancreas.

Novel prognostic markers revealed by a proteomic approach separating benign from malignant insulinomas.

Prognostic and Predictive Roles of MGMT Protein Expression and Promoter Methylation in Sporadic Pancreatic Neuroendocrine Neoplasms.

Evaluation of colon cancer histomorphology: a comparison between formalin and PAXgene tissue fixation by an international ring trial.

Glucagon-like-peptide-1 receptor expression in normal and diseased human thyroid and pancreas.