minimal-invasive-surgical-procedure-inducing-myocardial-infarction

Minimal Invasive Surgical Procedure of Inducing Myocardial Infarction in Mice

Myocardial infarction still remains the main cause of death in western countries, despite considerable progress in the stent development area in the last ...

induction-of-accelerated-atherosclerosis-in-mice-the-wire-injury-model

Induction of Accelerated Atherosclerosis in Mice: The "Wire-Injury" Model

Atherosclerosis is a proliferative fibro-inflammatory disease developing in the arterial wall, inducing a deficient blood flow or a lack of blood flow. ...

RWTH Aachen University, Germany

RWTH Aachen University

Platelet microparticles (PM) are the most abundant cell-derived microparticles in the blood, and accumulate in thrombo-inflammatory diseases. Platelets produce PM upon aging via an apoptosis-like process and by activation with strong agonists. We previously showed that long-term treatment of monocytic cells with apoptosis-induced PM (PMap) promotes their differentiation into resident macrophages. Here we investigated shorter term effects of various types of PM on monocyte signalling and function.

Aging- and activation-induced platelet microparticles suppress apoptosis in monocytic cells and differentially signal to proinflammatory mediator release.

The renin-angiotensin system and especially the angiotensin peptides play a central role in blood pressure regulation. Here, we hypothesize that an as-yet unknown peptide is involved in the action of angiotensin II modulating the vasoregulatory effects as a cofactor.

Identification of the Vasoconstriction-Inhibiting Factor (VIF), a Potent Endogenous Cofactor of Angiotensin II Acting on the Angiotensin II Type 2 Receptor.

Mareike Staudt

Institute for Molecular Cardiovascular Research

RWTH Aachen University, Germany

Minimal Invasive Surgical Procedure of Inducing Myocardial Infarction in Mice

Induction of Accelerated Atherosclerosis in Mice: The "Wire-Injury" Model

Mareike Staudt

.css-o250i3{font-size:18px;font-family:Open Sans,sans-serif;line-height:21.6px;}Institute for Molecular Cardiovascular Research

RWTH Aachen University, Germany

Minimal Invasive Surgical Procedure of Inducing Myocardial Infarction in Mice

Induction of Accelerated Atherosclerosis in Mice: The "Wire-Injury" Model

Institute for Molecular Cardiovascular Research