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Induction of Accelerated Atherosclerosis in Mice: The "Wire-Injury" Model

DOI :

10.3791/54571-v

0:05 min

August 25th, 2020

August 25th, 2020

9,581 Views

1Institute for Molecular Cardiovascular Research, RWTH Aachen University, 2Human Genetic Laboratory, University of Medicine and Pharmacy

This study describes an invasive procedure for the induction of accelerated atherosclerosis in mice. In comparison to other methods using electric- or cryo-induced injury, mechanical-induced injury mimics the human condition of restenosis after revascularization therapies and is ideal for the study of the molecular mechanisms involved.

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Induction

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