Philippe Amouyel

Alcohol intake and diet in France, the prominent role of lifestyle.

APOE promoter polymorphisms and dementia in the elderly.

Equivalence of indapamide SR and enalapril on microalbuminuria reduction in hypertensive patients with type 2 diabetes: the NESTOR Study.

Alcohol consumption and cardiovascular disease: differential effects in France and Northern Ireland. The PRIME study.

Alpha-synuclein locus duplication as a cause of familial Parkinson's disease.

Impact of genetic variation of PPARgamma in humans.

Frequency of fruit and vegetable consumption and coronary heart disease in France and Northern Ireland: the PRIME study.

The proteome and secretome of human arterial smooth muscle cells.

Household income is associated with the risk of metabolic syndrome in a sex-specific manner.

Sex hormone-binding globulin is a major determinant of the lipid profile: the PRIME study.

Association between beta-1 and beta-2 adrenergic receptor gene polymorphisms and the response to beta-blockade in patients with stable congestive heart failure.

Study of a new PPARgamma2 promoter polymorphism and haplotype analysis in a French population.

Fasting insulin concentrations and coronary heart disease incidence in France and Northern Ireland: the PRIME Study.

Trends in coronary heart disease in France during the second half of the 1990s.

Lack of association between certain candidate gene polymorphisms and the metabolic syndrome.

Lack of association between serological evidence of past Coxiella burnetii infection and incident ischaemic heart disease: nested case-control study.

Plasma cystatin-C and development of coronary heart disease: The PRIME Study.

Association study of the vascular endothelial growth factor gene with the risk of developing Alzheimer's disease.

A common variant of endothelial nitric oxide synthase (Glu298Asp) is associated with collateral development in patients with chronic coronary occlusions.

Association between peroxisome proliferator-activated receptor gamma haplotypes and the metabolic syndrome in French men and women.

The impact of beta-adrenoreceptor gene polymorphisms on survival in patients with congestive heart failure.

Fruit and vegetable consumption and risk of stroke: a meta-analysis of cohort studies.

Impact of APOA5/A4/C3 genetic polymorphisms on lipid variables and cardiovascular disease risk in French men.

[Cardiovascular risk factors: an update].

Association between the metabolic syndrome and parental history of premature cardiovascular disease.

The APOA4 Thr347->Ser347 polymorphism is not a major risk factor of obesity.

Association study of the Ubiquilin gene with Alzheimer's disease.

The serotonin transporter promoter polymorphism and suicide.

Independent contribution of dairy products and calcium intake to blood pressure variations at a population level.

A study of the relationships between KLF2 polymorphisms and body weight control in a French population.

Profiling of membrane proteins from human macrophages: comparison of two approaches.

Association study of the PIN1 gene with Alzheimer's disease.

Impact of the matrix metalloproteinase MMP-3 on dementia.

Study of the impact of perilipin polymorphisms in a French population.

Cholesterol 25-hydroxylase on chromosome 10q is a susceptibility gene for sporadic Alzheimer's disease.

Fruit and vegetable consumption and risk of coronary heart disease: a meta-analysis of cohort studies.

The impact of the AMPD1 gene polymorphism on exercise capacity, other prognostic parameters, and survival in patients with stable congestive heart failure: a study in 686 consecutive patients.

Impact of a CART promoter genetic variation on plasma lipid profile in a general population.

New insight into the association of apolipoprotein E genetic variants with carotid plaques and intima-media thickness.

Efficacy of indapamide SR compared with enalapril in elderly hypertensive patients with type 2 diabetes.

A possible role for the PPARG Pro12Ala polymorphism in preterm birth.

Bilirubin and coronary heart disease risk in the Prospective Epidemiological Study of Myocardial Infarction (PRIME).

Evidence of a role for lactadherin in Alzheimer's disease.

Association of arginase 1 gene polymorphisms with the risk of myocardial infarction and common carotid intima media thickness.

A prospective evaluation of left ventricular remodeling after inaugural anterior myocardial infarction as a function of gene polymorphisms in the renin-angiotensin-aldosterone, adrenergic, and metalloproteinase systems.

Association between the T-381C polymorphism of the brain natriuretic peptide gene and risk of type 2 diabetes in human populations.

Low-density lipoprotein receptor-related protein 8 gene polymorphisms and dementia.

Association study of the paraoxonase 1 gene with the risk of developing Alzheimer's disease.

Genetic heterogeneity of Alzheimer's disease: complexity and advances.

High consumptions of grain, fish, dairy products and combinations of these are associated with a low prevalence of metabolic syndrome.

Association of OAZ1 gene polymorphisms with subclinical and clinical vascular events.

Tea consumption is inversely associated with carotid plaques in women.

An apolipoprotein A-I gene promoter polymorphism associated with cognitive decline, but not with Alzheimer's disease.

Association study of the GAB2 gene with the risk of developing Alzheimer's disease.

Predicting left ventricular remodeling after a first myocardial infarction by plasma proteome analysis.

Distension of the carotid artery and risk of coronary events: the three-city study.

Haplotypes across ACE and the risk of Alzheimer's disease: the three-city study.

Association study of the CFH Y402H polymorphism with Alzheimer's disease.

Residential environment and blood pressure in the PRIME Study: is the association mediated by body mass index and waist circumference?

Angiotensin I-converting enzyme I/D polymorphism and suicidal behaviors.

Application of saturation dye 2D-DIGE proteomics to characterize proteins modulated by oxidized low density lipoprotein treatment of human macrophages.

Association study of the NEDD9 gene with the risk of developing Alzheimer's and Parkinson's disease.

A polymorphism in CALHM1 influences Ca2+ homeostasis, Abeta levels, and Alzheimer's disease risk.

Lack of association of genetic variants in the LRP8 gene with familial and sporadic myocardial infarction.

Contribution of novel biomarkers to incident stable angina and acute coronary syndrome: the PRIME Study.

Calf circumference is inversely associated with carotid plaques.

The APOA5 Trp19 allele is associated with metabolic syndrome via its association with plasma triglycerides.

Smoking habits, waist circumference and coronary artery disease risk relationship: the PRIME study.

Proteomic analysis of left ventricular remodeling in an experimental model of heart failure.

Is the ornithine transcarbamylase gene a genetic determinant of Alzheimer's disease?

In obese and non-obese adults, the cis-regulatory rs361072 promoter variant of PIK3CB is associated with insulin resistance not with type 2 diabetes.

Study of the genetic variability of ZAC1 (PLAGL1) in French population-based samples.

Ten-year all-cause mortality in presumably healthy subjects on lipid-lowering drugs (from the Prospective Epidemiological Study of Myocardial Infarction [PRIME] prospective cohort).

Influence of cholesteryl ester transfer protein, peroxisome proliferator-activated receptor alpha, apolipoprotein E, and apolipoprotein A-I polymorphisms on high-density lipoprotein cholesterol, apolipoprotein A-I, lipoprotein A-I, and lipoprotein A-I:A-II concentrations: the Prospective Epidemiological Study of Myocardial Infarction study.

INR variability in atrial fibrillation: a risk model for cerebrovascular events.

Excessive daytime sleepiness is an independent risk indicator for cardiovascular mortality in community-dwelling elderly: the three city study.

Characterization of arginase 1 gene polymorphisms in the Algerian population and association with blood pressure.

Fractalkine receptor/ligand genetic variants and carotid intima-media thickness.

Effect of an FTO polymorphism on fat mass, obesity, and type 2 diabetes mellitus in the French MONICA Study.

Contribution of cardiovascular risk factors to coronary risk in patients with intermittent claudication in the PRIME Cohort Study of European men.

Study of thyroid hormone receptor alpha gene polymorphisms on Alzheimer's disease.

Trends in plasma lipids, lipoproteins and dyslipidaemias in French adults, 1996-2007.

An age effect on the association of common variants of ACE with Alzheimer's disease.

Association of ornithine transcarbamylase gene polymorphisms with hypertension and coronary artery vasomotion.

Respective contribution of conventional risk factors and antihypertensive treatment to stable angina pectoris and acute coronary syndrome as the first presentation of coronary heart disease: the PRIME Study.

Fruits, vegetables and coronary heart disease.

Low plasma retinol predicts coronary events in healthy middle-aged men: the PRIME Study.

Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease.

A study of the association between the ADAM12 and SH3PXD2A (SH3MD1) genes and Alzheimer's disease.

Breast-feeding modulates the influence of the peroxisome proliferator-activated receptor-gamma (PPARG2) Pro12Ala polymorphism on adiposity in adolescents: The Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) cross-sectional study.

Associations between common genetic polymorphisms in angiopoietin-like proteins 3 and 4 and lipid metabolism and adiposity in European adolescents and adults.

Single-nucleotide polymorphism of CD36 locus and obesity in European adolescents.

Higher level of systemic C-reactive protein is independently predictive of coronary heart disease in older community-dwelling adults: the three-city study.

Peroxisome proliferator-activated receptor gamma polymorphisms and coronary heart disease.

The pursuit of susceptibility genes for Alzheimer's disease: progress and prospects.

Deciphering genetic susceptibility to frontotemporal lobar dementia.

Concordance of two multiple analytical approaches demonstrate that interaction between BMI and ADIPOQ haplotypes is a determinant of LDL cholesterol in a general French population.

Disability and incident coronary heart disease in older community-dwelling adults: the Three-City Study.

Systematic analysis of candidate genes for Alzheimer's disease in a French, genome-wide association study.

Implication of the immune system in Alzheimer's disease: evidence from genome-wide pathway analysis.

Decreased serine207 phosphorylation of troponin T as a biomarker for left ventricular remodelling after myocardial infarction.

Single nucleotide polymorphisms in the FADS gene cluster are associated with delta-5 and delta-6 desaturase activities estimated by serum fatty acid ratios.

No association between polymorphisms in the INSIG1 gene and the risk of type 2 diabetes and related traits.

Genome-wide analysis of genetic loci associated with Alzheimer disease.

Characteristics of current smokers, former smokers, and second-hand exposure and evolution between 1985 and 2007.

Profile of macrophages in human abdominal aortic aneurysms: a transcriptomic, proteomic, and antibody protein array study.

C-reactive protein, interleukin 6, fibrinogen and risk of sudden death in European middle-aged men: the PRIME study.

Relative contribution of lipids and apolipoproteins to incident coronary heart disease and ischemic stroke: the PRIME Study.

Combinatorial peptide ligand library plasma treatment: Advantages for accessing low-abundance proteins.

Genome-wide pathway analysis implicates intracellular transmembrane protein transport in Alzheimer disease.

Is the urea cycle involved in Alzheimer's disease?

The CALHM1 P86L polymorphism is a genetic modifier of age at onset in Alzheimer's disease: a meta-analysis study.

High blood pressure prevalence and control in a middle-aged French population and their associated factors: the MONA LISA study.

Common polymorphisms in six genes of the methyl group metabolism pathway and obesity in European adolescents.

Suggestive evidence of associations between liver X receptor β polymorphisms with type 2 diabetes mellitus and obesity in three cohort studies: HUNT2 (Norway), MONICA (France) and HELENA (Europe).

Gender differences in the implementation of cardiovascular prevention measures after an acute coronary event.

Genome-wide association study confirms BST1 and suggests a locus on 12q24 as the risk loci for Parkinson's disease in the European population.

Patterns of alcohol consumption and ischaemic heart disease in culturally divergent countries: the Prospective Epidemiological Study of Myocardial Infarction (PRIME).

Impact of incomplete DNase I treatment on human macrophage proteome analysis.

Deep plasma proteomic analysis of patients with left ventricular remodeling after a first myocardial infarction.

Strategy for purification and mass spectrometry identification of SELDI peaks corresponding to low-abundance plasma and serum proteins.

Ten-year risk of all-cause mortality: assessment of a risk prediction algorithm in a French general population.

Evidence of the association of BIN1 and PICALM with the AD risk in contrasting European populations.

Cardiovascular proteomics: translational studies to develop novel biomarkers in heart failure and left ventricular remodeling.

KNG1 Ile581Thr and susceptibility to venous thrombosis.

The role of clusterin, complement receptor 1, and phosphatidylinositol binding clathrin assembly protein in Alzheimer disease risk and cerebrospinal fluid biomarker levels.

Associations between common genetic polymorphisms in the liver X receptor alpha and its target genes with the serum HDL-cholesterol concentration in adolescents of the HELENA Study.

Effects of occupational and educational changes on obesity trends in France: the results of the MONICA-France survey 1986-2006.

Genetics of Alzheimer's disease: new evidences for an old hypothesis?

Association of vascular risk factors with cervical artery dissection and ischemic stroke in young adults.

Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease.

Association of plasma Aß peptides with blood pressure in the elderly.

Could clinical decision rules relying on cardiovascular risk models increase psychosocial inequalities in health? Results from the PRIME cohort study.

FADS1 genetic variability interacts with dietary α-linolenic acid intake to affect serum non-HDL-cholesterol concentrations in European adolescents.

A genome-wide association study identifies LIPA as a susceptibility gene for coronary artery disease.

Associations of complement factor H and smoking with early age-related macular degeneration: the ALIENOR study.

Association between a thyroid hormone receptor-α gene polymorphism and blood pressure but not with coronary heart disease risk.

Study of estrogen receptor-α and receptor-β gene polymorphisms on Alzheimer's disease.

Genome-wide association studies of cerebral white matter lesion burden: the CHARGE consortium.

Genome-wide scan identifies TNIP1, PSORS1C1, and RHOB as novel risk loci for systemic sclerosis.

Measures of abdominal adiposity and the risk of stroke: the MOnica Risk, Genetics, Archiving and Monograph (MORGAM) study.

Modifying effect of arterial hypertension on amyotrophic lateral sclerosis.

Genetics of venous thrombosis: insights from a new genome wide association study.

Genome-wide study links MTMR7 gene to variant Creutzfeldt-Jakob risk.

Quantitative mass spectrometry analysis using PAcIFIC for the identification of plasma diagnostic biomarkers for abdominal aortic aneurysm.

Genome-wide and gene-based association implicates FRMD6 in Alzheimer disease.

Association between IgM anti-herpes simplex virus and plasma amyloid-beta levels.

Both common variations and rare non-synonymous substitutions and small insertion/deletions in CLU are associated with increased Alzheimer risk.

Excessive daytime sleepiness and vascular events: the Three City Study.

Interregional differences in the clinical, biological and electrical characteristics of first acute coronary events in France: results from the MONICA registries.

Evidence for caveolin-1 as a new susceptibility gene regulating tissue fibrosis in systemic sclerosis.

Functional and genetic analysis of haplotypic sequence variation at the nicastrin genomic locus.

Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies.

Single polymorphism nucleotide rs1333049 on chromosome 9p21 is associated with carotid plaques but not with common carotid intima-media thickness in older adults. A combined analysis of the Three-City and the EVA studies.

Usefulness of circulating biomarkers for the prediction of left ventricular remodeling after myocardial infarction.

Common variants at 12q14 and 12q24 are associated with hippocampal volume.

Clinical usefulness of the metabolic syndrome for the risk of coronary heart disease does not exceed the sum of its individual components in older men and women. The Three-City (3C) Study.

Depressive symptoms, a time-dependent risk factor for coronary heart disease and stroke in middle-aged men: the PRIME Study.

Adipocytokines and the risk of ischemic stroke: the PRIME Study.

Caution in interpreting results from imputation analysis when linkage disequilibrium extends over a large distance: a case study on venous thrombosis.

Relationships between chronic use of statin therapy, presentation of acute coronary syndromes and one-year mortality after an incident acute coronary event.

ARMS2 A69S polymorphism and the risk for age-related maculopathy: the ALIENOR study.

Total ApoE and ApoE4 isoform assays in an Alzheimer's disease case-control study by targeted mass spectrometry (n=669): a pilot assay for methionine-containing proteotypic peptides.

Lipoprotein(a) plasma levels and the risk of cancer: the PRIME study.

C-reactive protein, fibrinogen, and cardiovascular disease prediction.

From genes to stroke subtypes.

The major element of 1-year prognosis in acute coronary syndromes is severity of initial clinical presentation: Results from the French MONICA registries.

TREM2 variants in Alzheimer's disease.

New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism.

Large-scale association analysis identifies new risk loci for coronary artery disease.

Role of proinflammatory CD68(+) mannose receptor(-) macrophages in peroxiredoxin-1 expression and in abdominal aortic aneurysms in humans.

Genetic and molecular insights into the role of PROX1 in glucose metabolism.

Multiple biomarkers for the prediction of ischemic stroke: the PRIME study.

Ischemic stroke is associated with the ABO locus: the EuroCLOT study.

Identification of additional proteins in differential proteomics using protein interaction networks.

The Val158Met COMT polymorphism is a modifier of the age at onset in Parkinson's disease with a sexual dimorphism.

Genome-wide association analysis identifies a susceptibility locus for pulmonary arterial hypertension.

A genome-wide search for common SNP x SNP interactions on the risk of venous thrombosis.

Attainment of low-density lipoprotein cholesterol target in the French general population according to levels of cardiovascular risk: Insights from the MONA LISA study.

Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.

A study on the polymorphisms of the renin-angiotensin system pathway genes for their effect on blood pressure levels in males from Algeria.

External validation of the 2008 Framingham cardiovascular risk equation for CHD and stroke events in a European population of middle-aged men. The PRIME study.

A genome-wide association study for venous thromboembolism: the extended cohorts for heart and aging research in genomic epidemiology (CHARGE) consortium.

The role of adiposity in cardiometabolic traits: a Mendelian randomization analysis.

Impact of occupational physical activity and related tasks on cardiovascular disease: emerging opportunities for prevention?

Circulating plasma serine208-phosphorylated troponin T levels are indicator of cardiac dysfunction.

Serum MMP-8: a novel indicator of left ventricular remodeling and cardiac outcome in patients after acute myocardial infarction.

A regulatory variant in CCR6 is associated with susceptibility to antitopoisomerase-positive systemic sclerosis.

Abdominal obesity and lower gray matter volume: a Mendelian randomization study.

Low-fat and high-fat dairy products are differently related to blood lipids and cardiovascular risk score.

Impact of APOE gene polymorphisms on the lipid profile in an Algerian population.

Association of HDL-related loci with age-related macular degeneration and plasma lutein and zeaxanthin: the Alienor study.

A meta-analysis of genome-wide association studies identifies ORM1 as a novel gene controlling thrombin generation potential.

Missense variant in TREML2 protects against Alzheimer's disease.

Effects of established BMI-associated loci on obesity-related traits in a French representative population sample.

Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease.

Genome-wide association interaction analysis for Alzheimer's disease.

Genome-wide analysis of multi-ancestry cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma.

Defining the role of common variation in the genomic and biological architecture of adult human height.

Hypomethylation of the promoter of the catalytic subunit of protein phosphatase 2A in response to hyperglycemia.