Yvonne Harcus

IL-4 is required to prevent filarial nematode development in resistant but not susceptible strains of mice.

Signal sequence analysis of expressed sequence tags from the nematode Nippostrongylus brasiliensis and the evolution of secreted proteins in parasites.

Selective maturation of dendritic cells by Nippostrongylus brasiliensis-secreted proteins drives Th2 immune responses.

Th2 induction by Nippostrongylus secreted antigens in mice deficient in B cells, eosinophils or MHC Class I-related receptors.

Praziquantel treatment of individuals exposed to Schistosoma haematobium enhances serological recognition of defined parasite antigens.

IL-4R signaling is required to induce IL-10 for the establishment of T(h)2 dominance.

The secretome of the filarial parasite, Brugia malayi: proteomic profile of adult excretory-secretory products.

Expansion of Foxp3+ regulatory T cells in mice infected with the filarial parasite Brugia malayi.

C-type lectins from the nematode parasites Heligmosomoides polygyrus and Nippostrongylus brasiliensis.

Dynamics of CD11c(+) dendritic cell subsets in lymph nodes draining the site of intestinal nematode infection.

Helminth secretions induce de novo T cell Foxp3 expression and regulatory function through the TGF-β pathway.

Proteomic analysis of secretory products from the model gastrointestinal nematode Heligmosomoides polygyrus reveals dominance of venom allergen-like (VAL) proteins.

Immune modulation and modulators in Heligmosomoides polygyrus infection.

Heligmosomoides polygyrus elicits a dominant nonprotective antibody response directed against restricted glycan and peptide epitopes.

Type 2 innate immunity in helminth infection is induced redundantly and acts autonomously following CD11c(+) cell depletion.

Secretion of protective antigens by tissue-stage nematode larvae revealed by proteomic analysis and vaccination-induced sterile immunity.

Innate and adaptive type 2 immune cell responses in genetically controlled resistance to intestinal helminth infection.

The secreted triose phosphate isomerase of Brugia malayi is required to sustain microfilaria production in vivo.

Secreted proteomes of different developmental stages of the gastrointestinal nematode Nippostrongylus brasiliensis.

MyD88 signaling inhibits protective immunity to the gastrointestinal helminth parasite Heligmosomoides polygyrus.

Commensal-pathogen interactions in the intestinal tract: lactobacilli promote infection with, and are promoted by, helminth parasites.

Exosomes secreted by nematode parasites transfer small RNAs to mammalian cells and modulate innate immunity.

Concerted Activity of IgG1 Antibodies and IL-4/IL-25-Dependent Effector Cells Trap Helminth Larvae in the Tissues following Vaccination with Defined Secreted Antigens, Providing Sterile Immunity to Challenge Infection.