Department of Molecular Microbiology
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Putting the Leishmania genome to work: functional genomics by transposon trapping and expression profiling.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences Jan, 2002 | Pubmed ID: 11839181
Non-pathogenic trypanosomatid protozoa as a platform for protein research and production.
Protein expression and purification Jul, 2002 | Pubmed ID: 12135552
Characterization of quinonoid-dihydropteridine reductase (QDPR) from the lower eukaryote Leishmania major.
The Journal of biological chemistry Oct, 2002 | Pubmed ID: 12151409
Leishmania LPG3 encodes a GRP94 homolog required for phosphoglycan synthesis implicated in parasite virulence but not viability.
The EMBO journal Sep, 2002 | Pubmed ID: 12198148
Protozomics: trypanosomatid parasite genetics comes of age.
Nature reviews. Genetics Jan, 2003 | Pubmed ID: 12509749
Transposon mutagenesis of Mycobacterium marinum identifies a locus linking pigmentation and intracellular survival.
Infection and immunity Feb, 2003 | Pubmed ID: 12540574
Functional identification of galactosyltransferases (SCGs) required for species-specific modifications of the lipophosphoglycan adhesin controlling Leishmania major-sand fly interactions.
The Journal of biological chemistry May, 2003 | Pubmed ID: 12604613
Improvements in transfection efficiency and tests of RNA interference (RNAi) approaches in the protozoan parasite Leishmania.
Molecular and biochemical parasitology May, 2003 | Pubmed ID: 12742588
Identification of genes encoding arabinosyltransferases (SCA) mediating developmental modifications of lipophosphoglycan required for sand fly transmission of leishmania major.
The Journal of biological chemistry Aug, 2003 | Pubmed ID: 12750366
The role(s) of lipophosphoglycan (LPG) in the establishment of Leishmania major infections in mammalian hosts.
Proceedings of the National Academy of Sciences of the United States of America Aug, 2003 | Pubmed ID: 12869694
Ether phospholipids and glycosylinositolphospholipids are not required for amastigote virulence or for inhibition of macrophage activation by Leishmania major.
The Journal of biological chemistry Nov, 2003 | Pubmed ID: 12944391
Functional genetic identification of PRP1, an ABC transporter superfamily member conferring pentamidine resistance in Leishmania major.
Molecular and biochemical parasitology Aug, 2003 | Pubmed ID: 12946844
Persistence without pathology in phosphoglycan-deficient Leishmania major.
Science (New York, N.Y.) Aug, 2003 | Pubmed ID: 12947201
The H region HTBF gene mediates terbinafine resistance in Leishmania major.
Molecular and biochemical parasitology Sep, 2003 | Pubmed ID: 12967714
An in vitro system for developmental and genetic studies of Leishmania donovani phosphoglycans.
Molecular and biochemical parasitology Aug, 2003 | Pubmed ID: 14550894
Sphingolipids are essential for differentiation but not growth in Leishmania.
The EMBO journal Nov, 2003 | Pubmed ID: 14609948
Vaccination with phosphoglycan-deficient Leishmania major protects highly susceptible mice from virulent challenge without inducing a strong Th1 response.
Journal of immunology (Baltimore, Md. : 1950) Mar, 2004 | Pubmed ID: 15004184
The LPG1 gene family of Leishmania major.
Molecular and biochemical parasitology Jul, 2004 | Pubmed ID: 15138063
Expression profiling using random genomic DNA microarrays identifies differentially expressed genes associated with three major developmental stages of the protozoan parasite Leishmania major.
Molecular and biochemical parasitology Jul, 2004 | Pubmed ID: 15138069
In vitro shuttle mutagenesis using engineered mariner transposons.
Methods in molecular biology (Clifton, N.J.) , 2004 | Pubmed ID: 15153636
Identification of a compensatory mutant (lpg2-REV) of Leishmania major able to survive as amastigotes within macrophages without LPG2-dependent glycoconjugates and its significance to virulence and immunization strategies.
Infection and immunity Jun, 2004 | Pubmed ID: 15155672
The application of gene expression microarray technology to kinetoplastid research.
Current molecular medicine Sep, 2004 | Pubmed ID: 15357212
Central memory T cells mediate long-term immunity to Leishmania major in the absence of persistent parasites.
Nature medicine Oct, 2004 | Pubmed ID: 15448686
Flypaper for parasites.
Cell Oct, 2004 | Pubmed ID: 15507202
Reconstitution of GDP-mannose transport activity with purified Leishmania LPG2 protein in liposomes.
The Journal of biological chemistry Jan, 2005 | Pubmed ID: 15542612
从诱导细菌或原生动物寄生虫利什曼原虫主要挑战的沙飞白蛉 duboscqi 防御的表征。
Infection and immunity Dec, 2004 | Pubmed ID: 15557638
Leishmania salvage and remodelling of host sphingolipids in amastigote survival and acidocalcisome biogenesis.
Molecular microbiology Mar, 2005 | Pubmed ID: 15720561
Eukaryotic UDP-galactopyranose mutase (GLF gene) in microbial and metazoal pathogens.
Eukaryotic cell Jun, 2005 | Pubmed ID: 15947206
Identification of a DNA fragment that increases mitotic stability of episomal linear DNAs in Leishmania major.
International journal for parasitology Aug, 2005 | Pubmed ID: 15996670
The genome of the kinetoplastid parasite, Leishmania major.
Science (New York, N.Y.) Jul, 2005 | Pubmed ID: 16020728
Structures of Leishmania major pteridine reductase complexes reveal the active site features important for ligand binding and to guide inhibitor design.
Journal of molecular biology Sep, 2005 | Pubmed ID: 16055151
Demonstration by heterologous expression that the Leishmania SCA1 gene encodes an arabinopyranosyltransferase.
Glycobiology Mar, 2006 | Pubmed ID: 16272216
Immunization with persistent attenuated Delta lpg2 Leishmania major parasites requires adjuvant to provide protective immunity in C57BL/6 mice.
Infection and immunity Jan, 2006 | Pubmed ID: 16369039
Genomic organization and expression of the expanded SCG/L/R gene family of Leishmania major: internal clusters and telomeric localization of SCGs mediating species-specific LPG modifications.
Molecular and biochemical parasitology Apr, 2006 | Pubmed ID: 16464509
Biochemical and genetic analysis of methylenetetrahydrofolate reductase in Leishmania metabolism and virulence.
The Journal of biological chemistry Dec, 2006 | Pubmed ID: 17032644
Redirection of sphingolipid metabolism toward de novo synthesis of ethanolamine in Leishmania.
The EMBO journal Feb, 2007 | Pubmed ID: 17290222
A lipophosphoglycan-independent development of Leishmania in permissive sand flies.
Microbes and infection / Institut Pasteur Mar, 2007 | Pubmed ID: 17307009
Two functionally divergent UDP-Gal nucleotide sugar transporters participate in phosphoglycan synthesis in Leishmania major.
The Journal of biological chemistry May, 2007 | Pubmed ID: 17347153
Comparisons of mutants lacking the Golgi UDP-galactose or GDP-mannose transporters establish that phosphoglycans are important for promastigote but not amastigote virulence in Leishmania major.
Infection and immunity Sep, 2007 | Pubmed ID: 17606605
Characterization of inositol phosphorylceramides from Leishmania major by tandem mass spectrometry with electrospray ionization.
Journal of the American Society for Mass Spectrometry Sep, 2007 | Pubmed ID: 17627842
The role of the mitochondrial glycine cleavage complex in the metabolism and virulence of the protozoan parasite Leishmania major.
The Journal of biological chemistry Jan, 2008 | Pubmed ID: 17981801
Phylogenomic and functional analysis of pterin-4a-carbinolamine dehydratase family (COG2154) proteins in plants and microorganisms.
Plant physiology Apr, 2008 | Pubmed ID: 18245455
Leishmania major intracellular survival is not altered in SHP-1 deficient mev or CD45-/- mice.
Experimental parasitology Nov, 2008 | Pubmed ID: 18682252
Developmentally regulated sphingolipid synthesis in African trypanosomes.
Molecular microbiology Oct, 2008 | Pubmed ID: 18699867
Amplification of an alternate transporter gene suppresses the avirulent phenotype of glucose transporter null mutants in Leishmania mexicana.
Molecular microbiology Jan, 2009 | Pubmed ID: 19017272
Migratory dermal dendritic cells act as rapid sensors of protozoan parasites.
PLoS pathogens Nov, 2008 | Pubmed ID: 19043558
Methylene tetrahydrofolate dehydrogenase/cyclohydrolase and the synthesis of 10-CHO-THF are essential in Leishmania major.
Molecular microbiology Mar, 2009 | Pubmed ID: 19183277
Leishmania donovani lacking the Golgi GDP-Man transporter LPG2 exhibit attenuated virulence in mammalian hosts.
Experimental parasitology Jul, 2009 | Pubmed ID: 19328787
Demonstration of genetic exchange during cyclical development of Leishmania in the sand fly vector.
Science (New York, N.Y.) Apr, 2009 | Pubmed ID: 19359589
A novel role for Stat1 in phagosome acidification and natural host resistance to intracellular infection by Leishmania major.
PLoS pathogens Apr, 2009 | Pubmed ID: 19381261
Regulated expression of the Leishmania major surface virulence factor lipophosphoglycan using conditionally destabilized fusion proteins.
Proceedings of the National Academy of Sciences of the United States of America May, 2009 | Pubmed ID: 19383793
Leishmania major lacking arginase (ARG) are auxotrophic for polyamines but retain infectivity to susceptible BALB/c mice.
Molecular and biochemical parasitology May, 2009 | Pubmed ID: 19393161
PTR1-dependent synthesis of tetrahydrobiopterin contributes to oxidant susceptibility in the trypanosomatid protozoan parasite Leishmania major.
Current genetics Jun, 2009 | Pubmed ID: 19396443
The enzymes of the 10-formyl-tetrahydrofolate synthetic pathway are found exclusively in the cytosol of the trypanosomatid parasite Leishmania major.
Molecular and biochemical parasitology Aug, 2009 | Pubmed ID: 19450731
Leishmania major phosphoglycans influence the host early immune response by modulating dendritic cell functions.
Infection and immunity Aug, 2009 | Pubmed ID: 19487470
Inoculation of killed Leishmania major into immune mice rapidly disrupts immunity to a secondary challenge via IL-10-mediated process.
Proceedings of the National Academy of Sciences of the United States of America Aug, 2009 | Pubmed ID: 19666482
A transposon toolkit for gene transfer and mutagenesis in protozoan parasites.
Genetica Mar, 2010 | Pubmed ID: 19763844
Identification of transport-critical residues in a folate transporter from the folate-biopterin transporter (FBT) family.
The Journal of biological chemistry Jan, 2010 | Pubmed ID: 19923217
Degradation of host sphingomyelin is essential for Leishmania virulence.
PLoS pathogens Dec, 2009 | Pubmed ID: 20011126
Phospholipid and sphingolipid metabolism in Leishmania.
Molecular and biochemical parasitology Apr, 2010 | Pubmed ID: 20026359
Leishmania major glycosylation mutants require phosphoglycans (lpg2-) but not lipophosphoglycan (lpg1-) for survival in permissive sand fly vectors.
PLoS neglected tropical diseases , 2010 | Pubmed ID: 20084096
Proteophosphoglycan confers resistance of Leishmania major to midgut digestive enzymes induced by blood feeding in vector sand flies.
Cellular microbiology Jul, 2010 | Pubmed ID: 20088949
Deletion of UDP-glucose pyrophosphorylase reveals a UDP-glucose independent UDP-galactose salvage pathway in Leishmania major.
Glycobiology Jul, 2010 | Pubmed ID: 20335578
Monitoring the efficacy of antimicrobial photodynamic therapy in a murine model of cutaneous leishmaniasis using L. major expressing GFP.
Journal of biophotonics Jun, 2010 | Pubmed ID: 20376860
Phosphoproteome dynamics reveal heat-shock protein complexes specific to the Leishmania donovani infectious stage.
Proceedings of the National Academy of Sciences of the United States of America May, 2010 | Pubmed ID: 20404152
A role for tetrahydrofolates in the metabolism of iron-sulfur clusters in all domains of life.
Proceedings of the National Academy of Sciences of the United States of America Jun, 2010 | Pubmed ID: 20489182
Expansion of the target of rapamycin (TOR) kinase family and function in Leishmania shows that TOR3 is required for acidocalcisome biogenesis and animal infectivity.
Proceedings of the National Academy of Sciences of the United States of America Jun, 2010 | Pubmed ID: 20551225
Remodeling of protein and mRNA expression in Leishmania mexicana induced by deletion of glucose transporter genes.
Molecular and biochemical parasitology Jan, 2011 | Pubmed ID: 20869991
Phenylalanine hydroxylase (PAH) from the lower eukaryote Leishmania major.
Molecular and biochemical parasitology Jan, 2011 | Pubmed ID: 20887755
Sphingolipids in parasitic protozoa.
Advances in experimental medicine and biology , 2010 | Pubmed ID: 20919659
Retention and loss of RNA interference pathways in trypanosomatid protozoans.
PLoS pathogens , 2010 | Pubmed ID: 21060810
Leishmania major survival in selective Phlebotomus papatasi sand fly vector requires a specific SCG-encoded lipophosphoglycan galactosylation pattern.
PLoS pathogens , 2010 | Pubmed ID: 21085609
Differential microbicidal effects of human histone proteins H2A and H2B on Leishmania promastigotes and amastigotes.
Infection and immunity Mar, 2011 | Pubmed ID: 21189319
Leishmania RNA virus controls the severity of mucocutaneous leishmaniasis.
Science (New York, N.Y.) Feb, 2011 | Pubmed ID: 21311023
The susceptibility of trypanosomatid pathogens to PI3/mTOR kinase inhibitors affords a new opportunity for drug repurposing.
PLoS neglected tropical diseases Aug, 2011 | Pubmed ID: 21886855
Muco-cutaneous leishmaniasis in the New World: the ultimate subversion.
Virulence Nov-Dec, 2011 | Pubmed ID: 21971185
Folate metabolic pathways in Leishmania.
Essays in biochemistry , 2011 | Pubmed ID: 22023442
[Mucocutaneous leishmaniasis and an undesired passenger].
Médecine sciences : M/S Nov, 2011 | Pubmed ID: 22130014
Killed but metabolically active Leishmania as a novel whole-cell vaccine for visceral leishmaniasis.
Clinical and vaccine immunology : CVI Feb, 2012 | Pubmed ID: 22323556
Colin J. Thalhofer1,
Joel W. Graff2,
Laurie Love-Homan3,
Suzanne M. Hickerson4,
Noah Craft5,
Stephen M. Beverley4,
Mary E. Wilson6,7
1Interdisciplinary Immunology Program, University of Iowa, and the VA Medical Center,
2Department of Biochemistry, University of Iowa, and the VA Medical Center,
3Department of Internal Medicine, University of Iowa,
4Department of Molecular Microbiology, Washington University School of Medicine,
5Division of Dermatology, Harbor-UCLA Medical Center, Hanley-Hardison Research Center,
6Interdisciplinary Immunology Program, Iowa City VA Medical Center,
7Departments of Internal Medicine, Microbiology and Epidemiology, University of Iowa
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