C. David James

Department of Neurological Surgery, University of California, San Francisco - UCSF

Affiliated withUniversity of California, San Francisco - UCSF

Research Area

NeuroscienceUnit 1

Biography

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JoVE Journal Publications

Article Total : 2	Year
Publication title	2010
Publication title	2010

Other Publications

Article	Year
A chromosomal region 7p11.2 transcript map: its development and application to the study of EGFR amplicons in glioblastoma. Neuro-oncology\| PubMed ID: 11916499	2002
Mucosa-associated lymphoid tissue lymphomas with t(11;18)(q21;q21) and mucosa-associated lymphoid tissue lymphomas with aneuploidy develop along different pathogenetic pathways. The American journal of pathology\| PubMed ID: 12107090	2002
Neuropathology of genetically engineered mice: consensus report and recommendations from an international forum. Oncogene\| PubMed ID: 12386807	2002
Combination of epidermal growth factor receptor targeted therapy with radiation therapy for malignant gliomas. Frontiers in bioscience : a journal and virtual library\| PubMed ID: 12456322	2003
Lanthionine synthetase components C-like 2 increases cellular sensitivity to adriamycin by decreasing the expression of P-glycoprotein through a transcription-mediated mechanism. Cancer research\| PubMed ID: 12566319	2003
Genetic and signaling pathway alterations in glioblastoma: relevance to novel targeted therapies. Frontiers in bioscience : a journal and virtual library\| PubMed ID: 12700121	2003
Contrasting in vivo and in vitro fates of glioblastoma cell subpopulations with amplified EGFR. Genes, chromosomes & cancer\| PubMed ID: 14603439	2004
MDA-7 regulates cell growth and radiosensitivity in vitro of primary (non-established) human glioma cells. Cancer biology & therapy\| PubMed ID: 15197348	2004
Correlation of the response of recurrent malignant gliomas treated with interferon alpha with tumor interferon alpha gene content. International journal of oncology\| PubMed ID: 15254740	2004
Immunohistochemical detection of EGFRvIII in high malignancy grade astrocytomas and evaluation of prognostic significance. Journal of neuropathology and experimental neurology\| PubMed ID: 15290895	2004
Altered molecular pathways in gliomas: an overview of clinically relevant issues. Seminars in oncology\| PubMed ID: 15497113	2004
Patient tumor EGFR and PDGFRA gene amplifications retained in an invasive intracranial xenograft model of glioblastoma multiforme. Neuro-oncology\| PubMed ID: 15831234	2005
Unique aspects of mda-7/IL-24 antitumor bystander activity: establishing a role for secretion of MDA-7/IL-24 protein by normal cells. Oncogene\| PubMed ID: 16044151	2005
mTOR controls FLIPS translation and TRAIL sensitivity in glioblastoma multiforme cells. Molecular and cellular biology\| PubMed ID: 16199861	2005
Disruption of parallel and converging signaling pathways contributes to the synergistic antitumor effects of simultaneous mTOR and EGFR inhibition in GBM cells. Neoplasia (New York, N.Y.)\| PubMed ID: 16242075	2005
Use of an orthotopic xenograft model for assessing the effect of epidermal growth factor receptor amplification on glioblastoma radiation response. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 16609043	2006
Tumor suppressor p16 methylation in multiple myeloma: biological and clinical implications. Blood\| PubMed ID: 16840723	2007
PIK3CA gene mutations in pediatric and adult glioblastoma multiforme. Molecular cancer research : MCR\| PubMed ID: 17050665	2006
Mapping the future of Neuro-Oncology. Neuro-oncology\| PubMed ID: 17170381	2007
Retargeted oncolytic measles strains entering via the EGFRvIII receptor maintain significant antitumor activity against gliomas with increased tumor specificity. Cancer research\| PubMed ID: 17178881	2006
Epidermal growth factor receptor (EGFR)-retargeted measles virus strains effectively target EGFR- or EGFRvIII expressing gliomas. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 17299404	2007
Rarity of PTEN deletions and EGFR amplification in malignant gliomas of childhood: results from the Children's Cancer Group 945 cohort. Journal of neurosurgery\| PubMed ID: 17328268	2006
Identification of molecular characteristics correlated with glioblastoma sensitivity to EGFR kinase inhibition through use of an intracranial xenograft test panel. Molecular cancer therapeutics\| PubMed ID: 17363510	2007
Epidermal growth factor receptor variant III status defines clinically distinct subtypes of glioblastoma. Journal of clinical oncology : official journal of the American Society of Clinical Oncology\| PubMed ID: 17538175	2007
Bioluminescence monitoring of intracranial glioblastoma xenograft: response to primary and salvage temozolomide therapy. Journal of neurosurgery\| PubMed ID: 17886562	2007
Disabled-1 is a large common fragile site gene, inactivated in multiple cancers. Genes, chromosomes & cancer\| PubMed ID: 18008369	2008
Combination of measles virus virotherapy and radiation therapy has synergistic activity in the treatment of glioblastoma multiforme. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 18056196	2007
An orthotopic skull base model of malignant meningioma. Brain pathology (Zurich, Switzerland)\| PubMed ID: 18093250	2008
Increased expression of the glioma-associated antigen ARF4L after loss of the tumor suppressor PTEN. Laboratory investigation. Journal of neurosurgery\| PubMed ID: 18240926	2008
Mechanisms of chemoresistance to alkylating agents in malignant glioma. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 18483356	2008
PTEN loss does not predict for response to RAD001 (Everolimus) in a glioblastoma orthotopic xenograft test panel. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 18559622	2008
miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells. BMC medicine\| PubMed ID: 18577219	2008
Abnormal DNA methylation of CD133 in colorectal and glioblastoma tumors. Cancer research\| PubMed ID: 18829568	2008
Induction of MGMT expression is associated with temozolomide resistance in glioblastoma xenografts. Neuro-oncology\| PubMed ID: 18952979	2009
Evaluation of MGMT promoter methylation status and correlation with temozolomide response in orthotopic glioblastoma xenograft model. Journal of neuro-oncology\| PubMed ID: 19011762	2009
p53 Small-molecule inhibitor enhances temozolomide cytotoxic activity against intracranial glioblastoma xenografts. Cancer research\| PubMed ID: 19074867	2008
Phase II study of erlotinib plus temozolomide during and after radiation therapy in patients with newly diagnosed glioblastoma multiforme or gliosarcoma. Journal of clinical oncology : official journal of the American Society of Clinical Oncology\| PubMed ID: 19075262	2009
Comparative analyses of gene copy number and mRNA expression in glioblastoma multiforme tumors and xenografts. Neuro-oncology\| PubMed ID: 19139420	2009
EGFR signals to mTOR through PKC and independently of Akt in glioma. Science signaling\| PubMed ID: 19176518	2009
Stem cells for treating glioblastoma: how close to reality? Neuro-oncology\| PubMed ID: 19237733	2009
Pathologic correlates of primary central nervous system lymphoma defined in an orthotopic xenograft model. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 19276270	2009
Fyn and SRC are effectors of oncogenic epidermal growth factor receptor signaling in glioblastoma patients. Cancer research\| PubMed ID: 19690143	2009
Radiosensitizing effects of temozolomide observed in vivo only in a subset of O6-methylguanine-DNA methyltransferase methylated glioblastoma multiforme xenografts. International journal of radiation oncology, biology, physics\| PubMed ID: 19695438	2009
microRNAs in gliomas: small regulators of a big problem. Neuromolecular medicine\| PubMed ID: 19731102	2009
Immunological considerations of modern animal models of malignant primary brain tumors. Journal of translational medicine\| PubMed ID: 19814820	2009
Reversing HOXA9 oncogene activation by PI3K inhibition: epigenetic mechanism and prognostic significance in human glioblastoma. Cancer research\| PubMed ID: 20068170	2010
Oncogenic BRAF mutation with CDKN2A inactivation is characteristic of a subset of pediatric malignant astrocytomas. Cancer research\| PubMed ID: 20068183	2010
Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1. Cancer cell\| PubMed ID: 20129251	2010
Noninvasive detection of target modulation following phosphatidylinositol 3-kinase inhibition using hyperpolarized 13C magnetic resonance spectroscopy. Cancer research\| PubMed ID: 20145128	2010
Hyperpolarized 13C magnetic resonance metabolic imaging: application to brain tumors. Neuro-oncology\| PubMed ID: 20150380	2010
Morphologic and molecular characterization of ATRT xenografts adapted for orthotopic therapeutic testing. Neuro-oncology\| PubMed ID: 20308314	2010
Pharmacologic inhibition of cyclin-dependent kinases 4 and 6 arrests the growth of glioblastoma multiforme intracranial xenografts. Cancer research\| PubMed ID: 20354191	2010
A hierarchy of self-renewing tumor-initiating cell types in glioblastoma. Cancer cell\| PubMed ID: 20385361	2010
Pleiotropic role for MYCN in medulloblastoma. Genes & development\| PubMed ID: 20478998	2010
Tumor-initiating cells: an influential paradigm for xenograft research. Neuro-oncology\| PubMed ID: 20530515	2010
Identification of internalizing human single-chain antibodies targeting brain tumor sphere cells. Molecular cancer therapeutics\| PubMed ID: 20587664	2010
Akt and autophagy cooperate to promote survival of drug-resistant glioma. Science signaling\| PubMed ID: 21062993	2010
Inhibition of PI3K/mTOR pathways in glioblastoma and implications for combination therapy with temozolomide. Neuro-oncology\| PubMed ID: 21317208	2011
Detection of early response to temozolomide treatment in brain tumors using hyperpolarized 13C MR metabolic imaging. Journal of magnetic resonance imaging : JMRI\| PubMed ID: 21590996	2011
Evolution of mouse models for studying CNS cancer: a decade of progress. Neuro-oncology\| PubMed ID: 21727207	2011
Hyperpolarized 13C MR spectroscopic imaging can be used to monitor Everolimus treatment in vivo in an orthotopic rodent model of glioblastoma. NeuroImage\| PubMed ID: 21807103	2012
Mutational inactivation of STAG2 causes aneuploidy in human cancer. Science (New York, N.Y.)\| PubMed ID: 21852505	2011
Phase I study of temsirolimus in combination with EKB-569 in patients with advanced solid tumors. Investigational new drugs\| PubMed ID: 21881915	2011
Investigation of intravenous delivery of nanoliposomal topotecan for activity against orthotopic glioblastoma xenografts. Neuro-oncology\| PubMed ID: 21954443	2011
Evidence for sequenced molecular evolution of IDH1 mutant glioblastoma from a distinct cell of origin. Journal of clinical oncology : official journal of the American Society of Clinical Oncology\| PubMed ID: 22025148	2011
Targeted therapy for BRAFV600E malignant astrocytoma. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 22038996	2011
An LXR agonist promotes GBM cell death through inhibition of an EGFR/AKT/SREBP-1/LDLR-dependent pathway. Cancer discovery\| PubMed ID: 22059152	2011
Stimulating anti-tumor immune response: the problem of regulatory T-cells. Neuro-oncology\| PubMed ID: 22113488	2011
Reduced phosphocholine and hyperpolarized lactate provide magnetic resonance biomarkers of PI3K/Akt/mTOR inhibition in glioblastoma. Neuro-oncology\| PubMed ID: 22156546	2011
Clinical stratification of glioblastoma based on alterations in retinoblastoma tumor suppressor protein (RB1) and association with the proneural subtype. Journal of neuropathology and experimental neurology\| PubMed ID: 22157621	2012
An experimental xenograft mouse model of diffuse pontine glioma designed for therapeutic testing. Journal of neuro-oncology\| PubMed ID: 22231932	2012
Challenges in drug delivery to tumors of the central nervous system: An overview of pharmacological and surgical considerations. Advanced drug delivery reviews\| PubMed ID: 22306489	2012