Department of Cell & Developmental Biology
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Molecular dissection of actopaxin-integrin-linked kinase-Paxillin interactions and their role in subcellular localization.
The Journal of biological chemistry Jan, 2002 | Pubmed ID: 11694518
The adaptor protein paxillin is essential for normal development in the mouse and is a critical transducer of fibronectin signaling.
Molecular and cellular biology Feb, 2002 | Pubmed ID: 11784865
The paxillin LD motifs.
FEBS letters Feb, 2002 | Pubmed ID: 11911889
A fragment of paxillin binds the alpha 4 integrin cytoplasmic domain (tail) and selectively inhibits alpha 4-mediated cell migration.
The Journal of biological chemistry Jun, 2002 | Pubmed ID: 11919182
Epidermal growth factor stimulates serine/threonine phosphorylation of the focal adhesion protein paxillin in a MEK-dependent manner in normal rat kidney cells.
Journal of cellular physiology Apr, 2002 | Pubmed ID: 11920684
Actopaxin is phosphorylated during mitosis and is a substrate for cyclin B1/cdc2 kinase.
The Biochemical journal Apr, 2002 | Pubmed ID: 11931650
Roles for the tubulin- and PTP-PEST-binding paxillin LIM domains in cell adhesion and motility.
The international journal of biochemistry & cell biology Jul, 2002 | Pubmed ID: 11950600
Paxillin-dependent paxillin kinase linker and p21-activated kinase localization to focal adhesions involves a multistep activation pathway.
Molecular biology of the cell May, 2002 | Pubmed ID: 12006652
Ca2+-dependent localization of integrin-linked kinase to cell junctions in differentiating keratinocytes.
The Journal of biological chemistry Mar, 2003 | Pubmed ID: 12547824
Extracellular signal-regulated kinase mediates phosphorylation of tropomyosin-1 to promote cytoskeleton remodeling in response to oxidative stress: impact on membrane blebbing.
Molecular biology of the cell Apr, 2003 | Pubmed ID: 12686598
Crk associates with a multimolecular Paxillin/GIT2/beta-PIX complex and promotes Rac-dependent relocalization of Paxillin to focal contacts.
Molecular biology of the cell Jul, 2003 | Pubmed ID: 12857867
RNF5, a RING finger protein that regulates cell motility by targeting paxillin ubiquitination and altered localization.
Molecular and cellular biology Aug, 2003 | Pubmed ID: 12861019
Expression of non-phosphorylatable paxillin mutants in canine tracheal smooth muscle inhibits tension development.
The Journal of physiology Nov, 2003 | Pubmed ID: 12949231
Tension development during contractile stimulation of smooth muscle requires recruitment of paxillin and vinculin to the membrane.
American journal of physiology. Cell physiology Feb, 2004 | Pubmed ID: 14576084
FAK-Src signalling through paxillin, ERK and MLCK regulates adhesion disassembly.
Nature cell biology Feb, 2004 | Pubmed ID: 14743221
Integrin-linked kinase: a possible role in scar contracture.
Annals of plastic surgery Feb, 2004 | Pubmed ID: 14745274
EphB1-mediated cell migration requires the phosphorylation of paxillin at Tyr-31/Tyr-118.
The Journal of biological chemistry Jul, 2004 | Pubmed ID: 15107421
Vinculin modulation of paxillin-FAK interactions regulates ERK to control survival and motility.
The Journal of cell biology May, 2004 | Pubmed ID: 15138291
Phosphorylation of actopaxin regulates cell spreading and migration.
The Journal of cell biology Sep, 2004 | Pubmed ID: 15353548
Paxillin: adapting to change.
Physiological reviews Oct, 2004 | Pubmed ID: 15383653
The integrin-linked kinase regulates cell morphology and motility in a rho-associated kinase-dependent manner.
The Journal of biological chemistry Dec, 2004 | Pubmed ID: 15485819
Actopaxin interacts with TESK1 to regulate cell spreading on fibronectin.
The Journal of biological chemistry Jun, 2005 | Pubmed ID: 15817463
Src and FAK kinases cooperate to phosphorylate paxillin kinase linker, stimulate its focal adhesion localization, and regulate cell spreading and protrusiveness.
Molecular biology of the cell Sep, 2005 | Pubmed ID: 16000375
Tyrosine-phosphorylated Hic-5 inhibits epidermal growth factor-induced lamellipodia formation.
Experimental cell research Nov, 2005 | Pubmed ID: 16183059
Regulation of paxillin family members during epithelial-mesenchymal transformation: a putative role for paxillin delta.
Journal of cell science Oct, 2005 | Pubmed ID: 16219691
Paxillin is essential for PTP-PEST-dependent regulation of cell spreading and motility: a role for paxillin kinase linker.
Journal of cell science Dec, 2005 | Pubmed ID: 16317044
CdGAP associates with actopaxin to regulate integrin-dependent changes in cell morphology and motility.
Current biology : CB Jul, 2006 | Pubmed ID: 16860736
Hic-5 contributes to epithelial-mesenchymal transformation through a RhoA/ROCK-dependent pathway.
Journal of cellular physiology Jun, 2007 | Pubmed ID: 17299801
TGF-beta1 slows the growth of pathogenic myofibroblasts through a mechanism requiring the focal adhesion protein, Hic-5.
The Journal of investigative dermatology Feb, 2008 | Pubmed ID: 17671518
Paxillin-dependent stimulation of microtubule catastrophes at focal adhesion sites.
Journal of cell science Jan, 2008 | Pubmed ID: 18187451
Hic-5 promotes the hypertrophic scar myofibroblast phenotype by regulating the TGF-beta1 autocrine loop.
The Journal of investigative dermatology Oct, 2008 | Pubmed ID: 18401422
Paxillin comes of age.
Journal of cell science Aug, 2008 | Pubmed ID: 18650496
Cross talk between paxillin and Rac is critical for mediation of barrier-protective effects by oxidized phospholipids.
American journal of physiology. Lung cellular and molecular physiology Oct, 2008 | Pubmed ID: 18676874
FAK engages multiple pathways to maintain survival of fibroblasts and epithelia: differential roles for paxillin and p130Cas.
Journal of cell science Feb, 2009 | Pubmed ID: 19126677
Paxillin-kinase-linker tyrosine phosphorylation regulates directional cell migration.
Molecular biology of the cell Nov, 2009 | Pubmed ID: 19776348
Emerging role of paxillin-PKL in regulation of cell adhesion, polarity and migration.
Cell adhesion & migration Jul-Sep, 2010 | Pubmed ID: 20372092
The cell adhesion-associated protein Git2 regulates morphogenetic movements during zebrafish embryonic development.
Developmental biology Jan, 2011 | Pubmed ID: 21034731
Distinct roles for paxillin and Hic-5 in regulating breast cancer cell morphology, invasion, and metastasis.
Molecular biology of the cell Feb, 2011 | Pubmed ID: 21148292
LNK (SH2B3) is a key regulator of integrin signaling in endothelial cells and targets α-parvin to control cell adhesion and migration.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology Jun, 2012 | Pubmed ID: 22441983
Hic-5 promotes invadopodia formation and invasion during TGF-β-induced epithelial-mesenchymal transition.
The Journal of cell biology Apr, 2012 | Pubmed ID: 22529104
Paxillin and Hic-5 interaction with vinculin is differentially regulated by Rac1 and RhoA.
PloS one , 2012 | Pubmed ID: 22629471
CdGAP regulates cell migration and adhesion dynamics in two-and three-dimensional matrix environments.
Cytoskeleton (Hoboken, N.J.) Sep, 2012 | Pubmed ID: 22907917
Actopaxin (α-parvin) phosphorylation is required for matrix degradation and cancer cell invasion.
The Journal of biological chemistry Oct, 2012 | Pubmed ID: 22955285
Beta2-adaptin binds actopaxin and regulates cell spreading, migration and matrix degradation.
PloS one , 2012 | Pubmed ID: 23056266
Diverse roles for the paxillin family of proteins in cancer.
Genes & cancer May, 2012 | Pubmed ID: 23226574
Paxillin kinase linker (PKL) regulates Vav2 signaling during cell spreading and migration.
Molecular biology of the cell Jun, 2013 | Pubmed ID: 23615439
LIM domains target actin regulators paxillin and zyxin to sites of stress fiber strain.
PloS one , 2013 | Pubmed ID: 23990882
The focal adhesion-localized CdGAP regulates matrix rigidity sensing and durotaxis.
PloS one , 2014 | Pubmed ID: 24632816
Paxillin inhibits HDAC6 to regulate microtubule acetylation, Golgi structure, and polarized migration.
The Journal of cell biology Aug, 2014 | Pubmed ID: 25070956
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