Janet L. Smith

A biologist's guide to synchrotron facilities: the BioSync web resource.

Identification of four candidate cGMP targets in Dictyostelium.

A novel cGMP signalling pathway mediating myosin phosphorylation and chemotaxis in Dictyostelium.

Dictyostelium discoideum has a single diacylglycerol kinase gene with similarity to mammalian theta isoforms.

Differential functional properties of calmodulin-dependent protein kinase IIgamma variants isolated from smooth muscle.

cGMP signalling: different ways to create a pathway.

A defined protein-detergent-lipid complex for crystallization of integral membrane proteins: The cytochrome b6f complex of oxygenic photosynthesis.

Toward understanding the mechanism of the complex cyclization reaction catalyzed by imidazole glycerolphosphate synthase: crystal structures of a ternary complex and the free enzyme.

Substrate-induced changes in the ammonia channel for imidazole glycerol phosphate synthase.

The purine repressor of Bacillus subtilis: a novel combination of domains adapted for transcription regulation.

Functional dissection of the Bacillus subtilis pur operator site.

Signaling pathways regulating Dictyostelium myosin II.

Structure of the cytochrome b6f complex of oxygenic photosynthesis: tuning the cavity.

Regulatory mechanism of Dictyostelium myosin light chain kinase A.

Crystal structure of imidazole glycerol-phosphate dehydratase: duplication of an unusual fold.

The structure of the RNA-dependent RNA polymerase from bovine viral diarrhea virus establishes the role of GTP in de novo initiation.

Evolution of photosynthesis: time-independent structure of the cytochrome b6f complex.

[Structure and function of the cytochrome b6f complex of oxygenic photosynthesis].

Cytochrome bc complexes: a common core of structure and function surrounded by diversity in the outlying provinces.

Design, expression, and purification of a Flaviviridae polymerase using a high-throughput approach to facilitate crystal structure determination.

Structure of the nucleotide complex of PyrR, the pyr attenuation protein from Bacillus caldolyticus, suggests dual regulation by pyrimidine and purine nucleotides.

A new arrangement of (beta/alpha)8 barrels in the synthase subunit of PLP synthase.

Identification of potent and selective RNA antagonists of the IFN-gamma-inducible CXCL10 chemokine.

Structure of the cytochrome b6f complex: new prosthetic groups, Q-space, and the 'hors d'oeuvres hypothesis' for assembly of the complex.

The apo and ternary complex structures of a chemotherapeutic target: human glycinamide ribonucleotide transformylase.

Structure of the Flavivirus helicase: implications for catalytic activity, protein interactions, and proteolytic processing.

Myosin light chain kinase A is activated by cGMP-dependent and cGMP-independent pathways.

The dictyostelium kinome--analysis of the protein kinases from a simple model organism.

Transmembrane traffic in the cytochrome b6f complex.

At a crossroad: standing still and moving forward.

Structural basis for macrolactonization by the pikromycin thioesterase.

Structural and mechanistic insights into polyketide macrolactonization from polyketide-based affinity labels.

Catalytic core of alphavirus nonstructural protein nsP4 possesses terminal adenylyltransferase activity.

Clearing the skies over modular polyketide synthases.

Functional characterization of cis and trans activity of the Flavivirus NS2B-NS3 protease.

Crystal structure of the ECH2 catalytic domain of CurF from Lyngbya majuscula. Insights into a decarboxylase involved in polyketide chain beta-branching.

GNAT-like strategy for polyketide chain initiation.

pyr RNA binding to the Bacillus caldolyticus PyrR attenuation protein - characterization and regulation by uridine and guanosine nucleotides.

Metal active site elasticity linked to activation of homocysteine in methionine synthases.

A 7μm mini-beam improves diffraction data from small or imperfect crystals of macromolecules.

Role for conserved residues of sindbis virus nonstructural protein 2 methyltransferase-like domain in regulation of minus-strand synthesis and development of cytopathic infection.

Biochemistry. An enzyme assembly line.

Mocr: a novel fusion tag for enhancing solubility that is compatible with structural biology applications.

Characterization of purified Sindbis virus nsP4 RNA-dependent RNA polymerase activity in vitro.

Proteins: ever larger, stranger and more dynamic.

Structure and functional analysis of RifR, the type II thioesterase from the rifamycin biosynthetic pathway.

Structural basis for binding specificity between subclasses of modular polyketide synthase docking domains.

Mini-beam collimator enables microcrystallography experiments on standard beamlines.

Metamorphic enzyme assembly in polyketide diversification.

Insights into tRNA-dependent amidotransferase evolution and catalysis from the structure of the Aquifex aeolicus enzyme.

Identification of inhibitors of yellow fever virus replication using a replicon-based high-throughput assay.

Polyketide decarboxylative chain termination preceded by o-sulfonation in curacin a biosynthesis.

Insights into the reactivation of cobalamin-dependent methionine synthase.

Crystal structures of dehydratase domains from the curacin polyketide biosynthetic pathway.

Structure of the Rift Valley fever virus nucleocapsid protein reveals another architecture for RNA encapsidation.

Biochemical and structural characterization of the tautomycetin thioesterase: analysis of a stereoselective polyketide hydrolase.

Conformational switch triggered by alpha-ketoglutarate in a halogenase of curacin A biosynthesis.

A general scheme for synthesis of substrate-based polyketide labels for acyl carrier proteins.

Structural basis for substrate activation and regulation by cystathionine beta-synthase (CBS) domains in cystathionine {beta}-synthase.

New ligation-independent cloning vectors compatible with a high-throughput platform for parallel construct expression evaluation using baculovirus-infected insect cells.

Terminal alkene formation by the thioesterase of curacin A biosynthesis: structure of a decarboxylating thioesterase.

JBluIce-EPICS control system for macromolecular crystallography.

Radiation damage in protein crystals is reduced with a micron-sized X-ray beam.

Structure and function of the RedJ protein, a thioesterase from the prodiginine biosynthetic pathway in Streptomyces coelicolor.

Heterologous production, purification and characterization of enzymatically active Sindbis virus nonstructural protein nsP1.

Structural basis of multifunctionality in a vitamin B12-processing enzyme.

Fast fluorescence techniques for crystallography beamlines.

A resource for discovering specific and universal biomarkers for distributed stem cells.

Automated sample-scanning methods for radiation damage mitigation and diffraction-based centering of macromolecular crystals.

A new structural form in the SAM/metal-dependent o‑methyltransferase family: MycE from the mycinamicin biosynthetic pathway.

A new generation of crystallographic validation tools for the protein data bank.

Structure and activity of DmmA, a marine haloalkane dehalogenase.

Targeting phosphoinositide 3-kinase δ for allergic asthma.