Department of Experimental Oncology
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Effective gene transfer to solid tumors using different nonviral gene delivery techniques: electroporation, liposomes, and integrin-targeted vector.
Cancer gene therapy Apr, 2002 | Pubmed ID: 11960291
Schedule-dependent interaction between vinblastine and cisplatin in Ehrlich ascites tumors in mice.
The Journal of pharmacology and experimental therapeutics Jul, 2002 | Pubmed ID: 12065735
Perturbation of blood flow as a mechanism of anti-tumour action of direct current electrotherapy.
Physiological measurement Feb, 2003 | Pubmed ID: 12636188
Electroporation of LPB sarcoma cells in vitro and tumors in vivo increases the radiosensitizing effect of cisplatin.
Anticancer research Jan-Feb, 2003 | Pubmed ID: 12680224
Pt(II) complexes with N-(3-pyridyl)-2-(4-(trifluoromethyl)phenyl)diazenecarboxamide and their reactions with glutathione.
Journal of inorganic biochemistry Jun, 2003 | Pubmed ID: 12763654
Effects of electrogenetherapy with p53wt combined with cisplatin on curvival of human tumor cell lines with different p53 status.
DNA and cell biology Dec, 2003 | Pubmed ID: 14683587
EPR oximetry of tumors in vivo in cancer therapy.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy May, 2004 | Pubmed ID: 15134738
Electrochemotherapy with cisplatin of cutaneous tumor lesions in breast cancer.
Anti-cancer drugs Jul, 2004 | Pubmed ID: 15205602
Antitumour effectiveness of hyperthermia is potentiated by local application of electric pulses to LPB tumours in mice.
Anticancer research Jul-Aug, 2004 | Pubmed ID: 15330182
Direct visualization of electroporation-assisted in vivo gene delivery to tumors using intravital microscopy - spatial and time dependent distribution.
BMC cancer Nov, 2004 | Pubmed ID: 15546484
Successful sphincter-saving treatment of anorectal malignant melanoma with electrochemotherapy, local excision and adjuvant brachytherapy.
Anti-cancer drugs Mar, 2005 | Pubmed ID: 15711188
The effect of high frequency electric pulses on muscle contractions and antitumor efficiency in vivo for a potential use in clinical electrochemotherapy.
Bioelectrochemistry (Amsterdam, Netherlands) Feb, 2005 | Pubmed ID: 15713562
Effective treatment of perianal tumors in dogs with electrochemotherapy.
Anticancer research Mar-Apr, 2005 | Pubmed ID: 15868917
Crystal structures and cytotoxicity of isopropylamine Pt(II) complexes: a trinuclear squarato-bridged [Pt3(mu2-C4O4)3(H2NPri)6].3H2O and a mononuclear cis-[Pt(NO3)2(H2NPri)2].
Journal of inorganic biochemistry Jul, 2005 | Pubmed ID: 15927264
Radiosensitising effect of electrochemotherapy with bleomycin in LPB sarcoma cells and tumors in mice.
BMC cancer , 2005 | Pubmed ID: 16168056
Sequence and time dependence of transfection efficiency of electrically-assisted gene delivery to tumors in mice.
Current drug delivery Jan, 2006 | Pubmed ID: 16472096
Cytotoxicity of different platinum (II) analogues to human tumour cell lines in vitro and murine tumour in vivo alone or combined with electroporation.
Anticancer research May-Jun, 2006 | Pubmed ID: 16827135
In vivo imaging of tumor growth after electrochemotherapy with cisplatin.
Biochemical and biophysical research communications Sep, 2006 | Pubmed ID: 16899227
The endothelial cytoskeleton as a target of electroporation-based therapies.
Molecular cancer therapeutics Dec, 2006 | Pubmed ID: 17172418
Electrogene therapy with p53 of murine sarcomas alone or combined with electrochemotherapy using cisplatin.
DNA and cell biology Dec, 2006 | Pubmed ID: 17233116
Effective treatment of multiple unresectable skin melanoma metastases by electrochemotherapy.
Croatian medical journal Jun, 2007 | Pubmed ID: 17589984
Electrotransfer of therapeutic molecules into tissues.
Current opinion in molecular therapeutics Dec, 2007 | Pubmed ID: 18041666
Gene electrotransfer into murine skeletal muscle: a systematic analysis of parameters for long-term gene expression.
Technology in cancer research & treatment Apr, 2008 | Pubmed ID: 18345697
The effect of electroporation pulses on functioning of the heart.
Medical & biological engineering & computing Aug, 2008 | Pubmed ID: 18415132
Electrochemotherapy compared to surgery for treatment of canine mast cell tumours.
In vivo (Athens, Greece) Jan-Feb, 2009 | Pubmed ID: 19368125
Limb sparing treatment of bleeding melanoma recurrence by electrochemotherapy.
Tumori May-Jun, 2009 | Pubmed ID: 19688986
Electric pulses used in electrochemotherapy and electrogene therapy do not significantly change the expression profile of genes involved in the development of cancer in malignant melanoma cells.
BMC cancer , 2009 | Pubmed ID: 19709437
Local and systemic antitumor effect of intratumoral and peritumoral IL-12 electrogene therapy on murine sarcoma.
Cancer biology & therapy Nov, 2009 | Pubmed ID: 19755854
Controlled systemic release of interleukin-12 after gene electrotransfer to muscle for cancer gene therapy alone or in combination with ionizing radiation in murine sarcomas.
The journal of gene medicine Dec, 2009 | Pubmed ID: 19777440
Melanoma metastases to the neck nodes: role of adjuvant irradiation.
International journal of radiation oncology, biology, physics Jul, 2010 | Pubmed ID: 19910139
Radiosensitizing effect of electrochemotherapy in a fractionated radiation regimen in radiosensitive murine sarcoma and radioresistant adenocarcinoma tumor model.
Radiation research Dec, 2009 | Pubmed ID: 19929414
Towards treatment planning and treatment of deep-seated solid tumors by electrochemotherapy.
Biomedical engineering online , 2010 | Pubmed ID: 20178589
Metastatic potential of melanoma cells is not affected by electrochemotherapy.
Melanoma research Jun, 2011 | Pubmed ID: 20216102
Irradiation, cisplatin, and 5-azacytidine upregulate cytomegalovirus promoter in tumors and muscles: implementation of non-invasive fluorescence imaging.
Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging Feb, 2011 | Pubmed ID: 20396957
Antivascular effects of electrochemotherapy: implications in treatment of bleeding metastases.
Expert review of anticancer therapy May, 2010 | Pubmed ID: 20470005
Cancer electrogene therapy with interleukin-12.
Current gene therapy Aug, 2010 | Pubmed ID: 20560875
Increased cellular uptake of biocompatible superparamagnetic iron oxide nanoparticles into malignant cells by an external magnetic field.
The Journal of membrane biology Jul, 2010 | Pubmed ID: 20602230
The influence of electroporation on cytotoxicity of anticancer ruthenium(III) complex KP1339 in vitro and in vivo.
Anticancer research Jun, 2010 | Pubmed ID: 20651351
Hyaluronidase and collagenase increase the transfection efficiency of gene electrotransfer in various murine tumors.
Human gene therapy Jan, 2012 | Pubmed ID: 21797718
Electrochemotherapy of chest wall breast cancer recurrence.
Cancer treatment reviews Aug, 2011 | Pubmed ID: 21856080
Surface modified magnetic nanoparticles for immuno-gene therapy of murine mammary adenocarcinoma.
Biomaterials Jun, 2012 | Pubmed ID: 22429983
In vivo molecular imaging and histological analysis of changes induced by electric pulses used for plasmid DNA electrotransfer to the skin: a study in a dorsal window chamber in mice.
The Journal of membrane biology Sep, 2012 | Pubmed ID: 22644389
Development of human cell biosensor system for genotoxicity detection based on DNA damage-induced gene expression.
Radiology and oncology Mar, 2010 | Pubmed ID: 22933890
Electrogene therapy with interleukin-12 in canine mast cell tumors.
Radiology and oncology Mar, 2011 | Pubmed ID: 22933932
Assessment of the tumourigenic and metastatic properties of SK-MEL28 melanoma cells surviving electrochemotherapy with bleomycin.
Radiology and oncology Mar, 2012 | Pubmed ID: 22933978
Intravital microscopy at the single vessel level brings new insights of vascular modification mechanisms induced by electropermeabilization.
Journal of controlled release : official journal of the Controlled Release Society Nov, 2012 | Pubmed ID: 23017380
IL-12 based gene therapy in veterinary medicine.
Journal of translational medicine Nov, 2012 | Pubmed ID: 23171444
Differential cellular effects of electroporation and electrochemotherapy in monolayers of human microvascular endothelial cells.
PloS one , 2012 | Pubmed ID: 23300747
Is survivin expression prognostic or predictive in malignant pleural mesothelioma?
Virchows Archiv : an international journal of pathology Mar, 2013 | Pubmed ID: 23358691
Radiosensitizing effect of intratumoral interleukin-12 gene electrotransfer in murine sarcoma.
BMC cancer Jan, 2013 | Pubmed ID: 23360213
Potentiation of electrochemotherapy by intramuscular IL-12 gene electrotransfer in murine sarcoma and carcinoma with different immunogenicity.
Radiology and oncology Dec, 2012 | Pubmed ID: 23412658
Tumor size and effectiveness of electrochemotherapy.
Radiology and oncology Mar, 2013 | Pubmed ID: 23450195
Differential mechanisms associated with vascular disrupting action of electrochemotherapy: intravital microscopy on the level of single normal and tumor blood vessels.
PloS one , 2013 | Pubmed ID: 23555705
Multiple delivery of siRNA against endoglin into murine mammary adenocarcinoma prevents angiogenesis and delays tumor growth.
PloS one , 2013 | Pubmed ID: 23593103
Biological properties of melanoma and endothelial cells after plasmid AMEP gene electrotransfer depend on integrin quantity on cells.
The Journal of membrane biology Nov, 2013 | Pubmed ID: 23649038
In vitro targeted gene electrotransfer to endothelial cells with plasmid DNA containing human endothelin-1 promoter.
The Journal of membrane biology Oct, 2013 | Pubmed ID: 23652810
Magnetofection: a reproducible method for gene delivery to melanoma cells.
BioMed research international , 2013 | Pubmed ID: 23862136
Gene electrotransfer of plasmid antiangiogenic metargidin peptide (AMEP) in disseminated melanoma: safety and efficacy results of a phase I first-in-man study.
Human gene therapy. Clinical development Sep, 2013 | Pubmed ID: 23980876
In vivo real-time monitoring system of electroporation mediated control of transdermal and topical drug delivery.
Journal of controlled release : official journal of the Controlled Release Society Dec, 2013 | Pubmed ID: 24113487
Electrochemotherapy with intravenous bleomycin injection: an observational study in superficial squamous cell carcinoma in cats.
Journal of feline medicine and surgery Apr, 2014 | Pubmed ID: 24127456
A novel method for speciation of Pt in human serum incubated with cisplatin, oxaliplatin and carboplatin by conjoint liquid chromatography on monolithic disks with UV and ICP-MS detection.
Talanta Nov, 2013 | Pubmed ID: 24148385
Determination of vinblastine in tumour tissue with liquid chromatography-high resolution mass spectrometry.
Talanta Nov, 2013 | Pubmed ID: 24148490
Evaluation of p21 promoter for interleukin 12 radiation induced transcriptional targeting in a mouse tumor model.
Molecular cancer Nov, 2013 | Pubmed ID: 24219565
Effect of ionizing radiation on human skeletal muscle precursor cells.
Radiology and oncology , 2013 | Pubmed ID: 24294183
Changing electrode orientation, but not pulse polarity, increases the efficacy of gene electrotransfer to tumors in vivo.
Bioelectrochemistry (Amsterdam, Netherlands) Dec, 2014 | Pubmed ID: 24411306
Low-magnification image analysis of Giemsa stained, electroporation and bleomycin treated endothelial monolayers provides reliable monolayer integrity data.
Toxicology in vitro : an international journal published in association with BIBRA Jun, 2014 | Pubmed ID: 24412537
Schedule-dependent interaction between vinblastine and irradiation in experimental sarcoma.
Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] Jul, 2014 | Pubmed ID: 24615190
Different incubation times of cells after gene electrotransfer in fetal bovine serum affect cell viability, but not transfection efficiency.
The Journal of membrane biology May, 2014 | Pubmed ID: 24648010
Intraoperative electrochemotherapy of colorectal liver metastases.
Journal of surgical oncology Sep, 2014 | Pubmed ID: 24782355
A cell-based biosensor system HepG2CDKN1A-DsRed for rapid and simple detection of genotoxic agents.
Biosensors & bioelectronics Nov, 2014 | Pubmed ID: 24861570
Modulation of activity of known cytotoxic ruthenium(III) compound (KP418) with hampered transmembrane transport in electrochemotherapy in vitro and in vivo.
The Journal of membrane biology Dec, 2014 | Pubmed ID: 24957014
In situ monitoring of electric field distribution in mouse tumor during electroporation.
Radiology Jan, 2015 | Pubmed ID: 25144647
Inhibitor of endocytosis impairs gene electrotransfer to mouse muscle in vivo.
Bioelectrochemistry (Amsterdam, Netherlands) Jun, 2015 | Pubmed ID: 25200990
Mcam Silencing With RNA Interference Using Magnetofection has Antitumor Effect in Murine Melanoma.
Molecular therapy. Nucleic acids Oct, 2014 | Pubmed ID: 25350580
Endoglin silencing has significant antitumor effect on murine mammary adenocarcinoma mediated by vascular targeted effect.
Current gene therapy , 2015 | Pubmed ID: 25619888
Modeling of microvascular permeability changes after electroporation.
PloS one , 2015 | Pubmed ID: 25793292
Adjuvant TNF-α therapy to electrochemotherapy with intravenous cisplatin in murine sarcoma exerts synergistic antitumor effectiveness.
Radiology and oncology Mar, 2015 | Pubmed ID: 25810699
Improved Specificity of Gene Electrotransfer to Skin Using pDNA Under the Control of Collagen Tissue-Specific Promoter.
The Journal of membrane biology Oct, 2015 | Pubmed ID: 25840832
Gene Electrotransfer of Canine Interleukin 12 into Canine Melanoma Cell Lines.
The Journal of membrane biology Oct, 2015 | Pubmed ID: 25840833
Nitroxoline impairs tumor progression in vitro and in vivo by regulating cathepsin B activity.
Oncotarget Aug, 2015 | Pubmed ID: 25848918
Gene Electrotransfer of Plasmid with Tissue Specific Promoter Encoding shRNA against Endoglin Exerts Antitumor Efficacy against Murine TS/A Tumors by Vascular Targeted Effects.
PloS one , 2015 | Pubmed ID: 25909447
Endoglin (CD105) Silencing Mediated by shRNA Under the Control of Endothelin-1 Promoter for Targeted Gene Therapy of Melanoma.
Molecular therapy. Nucleic acids May, 2015 | Pubmed ID: 25942402
Electrochemotherapy of tumors as in situ vaccination boosted by immunogene electrotransfer.
Cancer immunology, immunotherapy : CII Oct, 2015 | Pubmed ID: 26067277
Coupling treatment planning with navigation system: a new technological approach in treatment of head and neck tumors by electrochemotherapy.
Biomedical engineering online , 2015 | Pubmed ID: 26355773
Electrochemotherapy of colorectal liver metastases--an observational study of its effects on the electrocardiogram.
Biomedical engineering online , 2015 | Pubmed ID: 26356120
Electrotransfer of Plasmid DNA Encoding an Anti-Mouse Endoglin (CD105) shRNA to B16 Melanoma Tumors with Low and High Metastatic Potential Results in Pronounced Anti-Tumor Effects.
Cancers Dec, 2015 | Pubmed ID: 26712792
Bleomycin pharmacokinetics of bolus bleomycin dose in elderly cancer patients treated with electrochemotherapy.
Cancer chemotherapy and pharmacology May, 2016 | Pubmed ID: 26992379
Magnetic field contributes to the cellular uptake for effective therapy with magnetofection using plasmid DNA encoding against Mcam in B16F10 melanoma in vivo.
Nanomedicine (London, England) Mar, 2016 | Pubmed ID: 27021639
Visualization of Nonspecific Antitumor Effectiveness and Vascular Effects of Gene Electro-Transfer to Tumors.
Current gene therapy , 2016 | Pubmed ID: 27029945
Recommendations for improving the quality of reporting clinical electrochemotherapy studies based on qualitative systematic review.
Radiology and oncology Mar, 2016 | Pubmed ID: 27069444
Effectiveness of electrochemotherapy after IFN-α adjuvant therapy of melanoma patients.
Radiology and oncology Mar, 2016 | Pubmed ID: 27069446
Cytotoxic trans-platinum(II) complex with 3-hydroxymethylpyridine: Synthesis, X-ray structure and biological activity evaluation.
Journal of inorganic biochemistry Aug, 2016 | Pubmed ID: 27189143
European Research on Electrochemotherapy in Head and Neck Cancer (EURECA) project: Results of the treatment of skin cancer.
European journal of cancer (Oxford, England : 1990) Aug, 2016 | Pubmed ID: 27267144
Cytosolic DNA Sensor Upregulation Accompanies DNA Electrotransfer in B16.F10 Melanoma Cells.
Molecular therapy. Nucleic acids Jun, 2016 | Pubmed ID: 27271988
Bystander Effect Induced by Electroporation is Possibly Mediated by Microvesicles and Dependent on Pulse Amplitude, Repetition Frequency and Cell Type.
The Journal of membrane biology Oct, 2016 | Pubmed ID: 27371159
Electrotransfer parameters as a tool for controlled and targeted gene expression in skin.
Molecular therapy. Nucleic acids Aug, 2016 | Pubmed ID: 27574782
Identification and quantification of bleomycin in serum and tumor tissue by liquid chromatography coupled to high resolution mass spectrometry.
Talanta Nov, 2016 | Pubmed ID: 27591601
Electrochemotherapy with bleomycin is effective in BRAF mutated melanoma cells and interacts with BRAF inhibitors.
Radiology and oncology Sep, 2016 | Pubmed ID: 27679543
Natasa Tozon1,
Ursa Lampreht Tratar2,
Katarina Znidar3,
Gregor Sersa2,
Justin Teissie4,5,
Maja Cemazar2,3
1Clinic for Surgery and Small Animals, Veterinary Faculty, University of Ljubljana,
2Department of Experimental Oncology, Institute of Oncology Ljubljana,
3Faculty of Health Sciences, University of Primorska,
4IPBS (Institut de Pharmacologie et de Biologie Structurale), CNRS,
5IPBS (Institut de Pharmacologie et de Biologie Structurale), Université de Toulouse
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