The Shapiro Family Laboratory of Viral Oncology and Aging Research
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The telomeric length and heterogeneity decrease with age in normal human oral keratinocytes.
Mechanisms of ageing and development Mar, 2002 | Pubmed ID: 11850022
gp120-Independent infection of CD4(-) epithelial cells and CD4(+) T-cells by HIV-1.
Journal of acquired immune deficiency syndromes (1999) May, 2002 | Pubmed ID: 12048357
5.3 Global challenges in research and strategic planning.
European journal of dental education : official journal of the Association for Dental Education in Europe , 2002 | Pubmed ID: 12390276
UCLA School of Dentistry: successes, challenges, and opportunities.
Journal of the California Dental Association Oct, 2002 | Pubmed ID: 12403477
Cytokine dependent inverse regulation of CD54 (ICAM1) and major histocompatibility complex class I antigens by nuclear factor kappaB in HEp2 tumor cell line: effect on the function of natural killer cells.
Human immunology May, 2003 | Pubmed ID: 12691701
Absence of hamTERT gene expression is associated with promoter hypermethylation in immortal hamster buccal pouch epithelial cells.
International journal of oncology Jun, 2003 | Pubmed ID: 12739004
Senescence-associated genes in normal human oral keratinocytes.
Experimental cell research Jul, 2003 | Pubmed ID: 12837283
Telomere shortening does not occur during postmaturational aging in situ in normal human oral fibroblasts.
Mechanisms of ageing and development Aug-Sep, 2003 | Pubmed ID: 14499491
Introduction of human telomerase reverse transcriptase to normal human fibroblasts enhances DNA repair capacity.
Clinical cancer research : an official journal of the American Association for Cancer Research Apr, 2004 | Pubmed ID: 15073136
Senescence occurs with hTERT repression and limited telomere shortening in human oral keratinocytes cultured with feeder cells.
Journal of cellular physiology Jun, 2004 | Pubmed ID: 15095283
Identification of cis sequences required for lytic DNA replication and packaging of murine gammaherpesvirus 68.
Journal of virology Sep, 2004 | Pubmed ID: 15308708
Interleukin 6 and interleukin 8 as potential biomarkers for oral cavity and oropharyngeal squamous cell carcinoma.
Archives of otolaryngology--head & neck surgery Aug, 2004 | Pubmed ID: 15313862
Salivary transcriptome diagnostics for oral cancer detection.
Clinical cancer research : an official journal of the American Association for Cancer Research Dec, 2004 | Pubmed ID: 15623624
Normal human oral keratinocytes demonstrate abnormal DNA end joining activity during replicative senescence.
Mechanisms of ageing and development Apr, 2005 | Pubmed ID: 15722106
Senescence-associated decline in the intranuclear accumulation of hOGG1-alpha and impaired 8-oxo-dG repair activity in senescing normal human oral keratinocytes in vivo.
Experimental cell research Oct, 2005 | Pubmed ID: 16122734
A dental school and a bank: partnership for community service.
Journal of the California Dental Association Jul, 2005 | Pubmed ID: 16164058
HPV-16 E6 oncoprotein impairs the fidelity of DNA end-joining via p53-dependent and -independent pathways.
International journal of oncology Jan, 2006 | Pubmed ID: 16327998
Abnormal DNA end-joining activity in human head and neck cancer.
International journal of molecular medicine May, 2006 | Pubmed ID: 16596281
Heterogeneous nuclear ribonucleoprotein G shows tumor suppressive effect against oral squamous cell carcinoma cells.
Clinical cancer research : an official journal of the American Association for Cancer Research May, 2006 | Pubmed ID: 16707624
Deregulation of eIF4E: 4E-BP1 in differentiated human papillomavirus-containing cells leads to high levels of expression of the E7 oncoprotein.
Journal of virology Jul, 2006 | Pubmed ID: 16809313
Bmi-1 cooperates with human papillomavirus type 16 E6 to immortalize normal human oral keratinocytes.
Experimental cell research Feb, 2007 | Pubmed ID: 17161394
p53 promotes the fidelity of DNA end-joining activity by, in part, enhancing the expression of heterogeneous nuclear ribonucleoprotein G.
DNA repair Jun, 2007 | Pubmed ID: 17387044
Extension of cell life span using exogenous telomerase.
Methods in molecular biology (Clifton, N.J.) , 2007 | Pubmed ID: 17634580
Microarray analysis of Bmi-1 downstream genes in normal human oral keratinocytes.
Journal of the California Dental Association Dec, 2007 | Pubmed ID: 18240749
Heterogeneous nuclear ribonucleoprotein G, nitric oxide, and oral carcinogenesis.
Nitric oxide : biology and chemistry Sep, 2008 | Pubmed ID: 18474262
hnRNP G elicits tumor-suppressive activity in part by upregulating the expression of Txnip.
Biochemical and biophysical research communications Aug, 2008 | Pubmed ID: 18541147
A role for fibroblasts in mediating the effects of tobacco-induced epithelial cell growth and invasion.
Molecular cancer research : MCR Jul, 2008 | Pubmed ID: 18644973
HIV-1 Tat enhances replicative potential of human oral keratinocytes harboring HPV-16 genome.
International journal of oncology Oct, 2008 | Pubmed ID: 18813791
Association of hsp90 to the hTERT promoter is necessary for hTERT expression in human oral cancer cells.
Carcinogenesis Dec, 2008 | Pubmed ID: 18820283
Regulation of IGFBP6 gene and protein is mediated by the inverse expression and function of c-jun N-terminal kinase (JNK) and NFkappaB in a model of oral tumor cells.
Apoptosis : an international journal on programmed cell death Dec, 2008 | Pubmed ID: 18982452
Salivary transcriptomic biomarkers for detection of resectable pancreatic cancer.
Gastroenterology Mar, 2010 | Pubmed ID: 19931263
Bmi-1 extends the life span of normal human oral keratinocytes by inhibiting the TGF-beta signaling.
Experimental cell research Oct, 2010 | Pubmed ID: 20630502
Increased lysis of stem cells but not their differentiated cells by natural killer cells; de-differentiation or reprogramming activates NK cells.
PloS one Jul, 2010 | Pubmed ID: 20661281
Grainyhead-like 2 enhances the human telomerase reverse transcriptase gene expression by inhibiting DNA methylation at the 5'-CpG island in normal human keratinocytes.
The Journal of biological chemistry Dec, 2010 | Pubmed ID: 20938050
miR-181a shows tumor suppressive effect against oral squamous cell carcinoma cells by downregulating K-ras.
Biochemical and biophysical research communications Jan, 2011 | Pubmed ID: 21167132
Radioprotective effects of Bmi-1 involve epigenetic silencing of oxidase genes and enhanced DNA repair in normal human keratinocytes.
The Journal of investigative dermatology Jun, 2011 | Pubmed ID: 21307872
Impaired odontogenic differentiation of senescent dental mesenchymal stem cells is associated with loss of Bmi-1 expression.
Journal of endodontics May, 2011 | Pubmed ID: 21496667
Identification of senescence-inducing microRNAs in normal human keratinocytes.
International journal of oncology Nov, 2011 | Pubmed ID: 21725593
Expression and mutation analysis of heterogeneous nuclear ribonucleoprotein G in human oral cancer.
Oral oncology Nov, 2011 | Pubmed ID: 21840245
DeltaNp63α protein triggers epithelial-mesenchymal transition and confers stem cell properties in normal human keratinocytes.
The Journal of biological chemistry Nov, 2011 | Pubmed ID: 21880709
Development of transcriptomic biomarker signature in human saliva to detect lung cancer.
Cellular and molecular life sciences : CMLS Oct, 2012 | Pubmed ID: 22689099
TNFα enhances cancer stem cell-like phenotype via Notch-Hes1 activation in oral squamous cell carcinoma cells.
Biochemical and biophysical research communications Jul, 2012 | Pubmed ID: 22728043
Histone demethylases KDM4B and KDM6B promotes osteogenic differentiation of human MSCs.
Cell stem cell Jul, 2012 | Pubmed ID: 22770241
Camphorquinone inhibits odontogenic differentiation of dental pulp cells and triggers release of inflammatory cytokines.
Journal of endodontics Jan, 2013 | Pubmed ID: 23228258
Efavirenz induces autophagy and aberrant differentiation in normal human keratinocytes.
International journal of molecular medicine Jun, 2013 | Pubmed ID: 23563240
2-Hydroxyethyl methacrylate inhibits migration of dental pulp stem cells.
Journal of endodontics Sep, 2013 | Pubmed ID: 23953290
Development of oral osteomucosal tissue constructs in vitro and localization of fluorescently-labeled bisphosphonates to hard and soft tissue.
International journal of molecular medicine Aug, 2014 | Pubmed ID: 24920042
Kaposi's sarcoma-associated herpesvirus ORF18 and ORF30 are essential for late gene expression during lytic replication.
Journal of virology Oct, 2014 | Pubmed ID: 25056896
Wnt4 signaling prevents skeletal aging and inflammation by inhibiting nuclear factor-κB.
Nature medicine Sep, 2014 | Pubmed ID: 25108526
Impaired bone resorption and woven bone formation are associated with development of osteonecrosis of the jaw-like lesions by bisphosphonate and anti-receptor activator of NF-κB ligand antibody in mice.
The American journal of pathology Nov, 2014 | Pubmed ID: 25173134
Osteo-/odontogenic differentiation of induced mesenchymal stem cells generated through epithelial-mesenchyme transition of cultured human keratinocytes.
Journal of endodontics Nov, 2014 | Pubmed ID: 25201509
The p63 Gene Is Regulated by Grainyhead-like 2 (GRHL2) through Reciprocal Feedback and Determines the Epithelial Phenotype in Human Keratinocytes.
The Journal of biological chemistry Aug, 2015 | Pubmed ID: 26085095
Regulation of p53 during senescence in normal human keratinocytes.
Aging cell Oct, 2015 | Pubmed ID: 26138448
Addendum: Wnt4 signaling prevents skeletal aging and inflammation by inhibiting nuclear factor-κB.
Nature medicine Sep, 2015 | Pubmed ID: 26340120
Nanodiamond-Gutta Percha Composite Biomaterials for Root Canal Therapy.
ACS nano Nov, 2015 | Pubmed ID: 26452304
Elevated expression of JMJD6 is associated with oral carcinogenesis and maintains cancer stemness properties.
Carcinogenesis Feb, 2016 | Pubmed ID: 26645717
Human papillomavirus 16 (HPV16) enhances tumor growth and cancer stemness of HPV-negative oral/oropharyngeal squamous cell carcinoma cells via miR-181 regulation.
Papillomavirus research (Amsterdam, Netherlands) Dec, 2015 | Pubmed ID: 26693182
Grainyhead-like 2 regulates epithelial plasticity and stemness in oral cancer cells.
Carcinogenesis May, 2016 | Pubmed ID: 26933170
Modeling the Etiology of p53-mutated Cancer Cells.
The Journal of biological chemistry May, 2016 | Pubmed ID: 27022024
Orai1 mediates osteogenic differentiation via BMP signaling pathway in bone marrow mesenchymal stem cells.
Biochemical and biophysical research communications May, 2016 | Pubmed ID: 27086849
Orai1 promotes tumor progression by enhancing cancer stemness via NFAT signaling in oral/oropharyngeal squamous cell carcinoma.
Oncotarget Jul, 2016 | Pubmed ID: 27259269
IL-36 Induces Bisphosphonate-Related Osteonecrosis of the Jaw-Like Lesions in Mice by Inhibiting TGF-β-Mediated Collagen Expression.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research Aug, 2016 | Pubmed ID: 27567012
Preexisting Periapical Inflammatory Condition Exacerbates Tooth Extraction-induced Bisphosphonate-related Osteonecrosis of the Jaw Lesions in Mice.
Journal of endodontics Nov, 2016 | Pubmed ID: 27637460
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