Erwin Sigel

N-Substituted 4-amino-3,3-dipropyl-2(3H)-furanones: new positive allosteric modulators of the GABA(A) receptor sharing electrophysiological properties with the anticonvulsant loreclezole.

Mapping of the benzodiazepine recognition site on GABA(A) receptors.

Functional characterization of the new human GABA(A) receptor mutation beta3(R192H).

Forced subunit assembly in alpha1beta2gamma2 GABAA receptors. Insight into the absolute arrangement.

Anxiolytic effect of wogonin, a benzodiazepine receptor ligand isolated from Scutellaria baicalensis Georgi.

On high- and low-affinity agonist sites in GABAA receptors.

On the benzodiazepine binding pocket in GABAA receptors.

Naturally occurring 2'-hydroxyl-substituted flavonoids as high-affinity benzodiazepine site ligands.

Individual properties of the two functional agonist sites in GABA(A) receptors.

Exon 17 skipping in CLCN1 leads to recessive myotonia congenita.

Positioning of the alpha-subunit isoforms confers a functional signature to gamma-aminobutyric acid type A receptors.

The flavone hispidulin, a benzodiazepine receptor ligand with positive allosteric properties, traverses the blood-brain barrier and exhibits anticonvulsive effects.

Techniques: Use of concatenated subunits for the study of ligand-gated ion channels.

Benzodiazepines affect channel opening of GABA A receptors induced by either agonist binding site.

Conformational changes at benzodiazepine binding sites of GABA(A) receptors detected with a novel technique.

The Xenopus oocyte: system for the study of functional expression and modulation of proteins.

Novel plant substances acting as beta subunit isoform-selective positive allosteric modulators of GABAA receptors.

Influence of the point mutation alpha-1-H101R on the assembly of gamma-aminobutyric acid type A receptors.

Consequence of the presence of two different beta subunit isoforms in a GABA(A) receptor.

A GABA(A) receptor of defined subunit composition and positioning: concatenation of five subunits.

Proximity-accelerated chemical coupling reaction in the benzodiazepine-binding site of gamma-aminobutyric acid type A receptors: superposition of different allosteric modulators.

Two neighboring residues of loop A of the alpha1 subunit point towards the benzodiazepine binding site of GABAA receptors.

Replacement of histidine in position 105 in the α₅ subunit by cysteine stimulates zolpidem sensitivity of α₅β₂γ₂ GABA(A) receptors.

The promiscuous role of the epsilon subunit in GABAA receptor biogenesis.

Anticipating antiport in P-type ATPases.

Novel chloride channel mutations leading to mild myotonia among Chinese.

Covalent modification of GABAA receptor isoforms by a diazepam analogue provides evidence for a novel benzodiazepine binding site that prevents modulation by these drugs.

Unanticipated structural and functional properties of delta-subunit-containing GABAA receptors.

Structure of alpha6 beta3 delta GABA(A) receptors and their lack of ethanol sensitivity.

Relative positioning of diazepam in the benzodiazepine-binding-pocket of GABA receptors.

Use of concatamers to study GABAA receptor architecture and function: application to delta-subunit-containing receptors and possible pitfalls.

Highly potent modulation of GABA(A) receptors by valerenic acid derivatives.

Diversity of structure and function of alpha1alpha6beta3delta GABAA receptors: comparison with alpha1beta3delta and alpha6beta3delta receptors.

Monepantel allosterically activates DEG-3/DES-2 channels of the gastrointestinal nematode Haemonchus contortus.

A residue close to α1 loop F disrupts modulation of GABAA receptors by benzodiazepines while their binding is maintained.

A closer look at the high affinity benzodiazepine binding site on GABAA receptors.

The major central endocannabinoid directly acts at GABA(A) receptors.

myo-Inositol uptake is essential for bulk inositol phospholipid but not glycosylphosphatidylinositol synthesis in Trypanosoma brucei.

A venom-derived neurotoxin, CsTx-1, from the spider Cupiennius salei exhibits cytolytic activities.

Influence of GABA(A) receptor α subunit isoforms on the benzodiazepine binding site.

Azo-propofols: photochromic potentiators of GABA(A) receptors.

Structure, function, and modulation of GABA(A) receptors.

Molecular analysis of the site for 2-arachidonylglycerol (2-AG) on the β₂ subunit of GABA(A) receptors.

Characterization of choline uptake in Trypanosoma brucei procyclic and bloodstream forms.

acr-23 Encodes a monepantel-sensitive channel in Caenorhabditis elegans.

Do N-arachidonyl-glycine (NA-glycine) and 2-arachidonoyl glycerol (2-AG) share mode of action and the binding site on the β2 subunit of GABAA receptors?

Relative positioning of classical benzodiazepines to the γ2-subunit of GABAA receptors.

Accelerated discovery of novel benzodiazepine ligands by experiment-guided virtual screening.

Moderate concentrations of 4-O-methylhonokiol potentiate GABAA receptor currents stronger than honokiol.

Trypanosoma brucei eflornithine transporter AAT6 is a low-affinity low-selective transporter for neutral amino acids.

A pentasymmetric open channel blocker for Cys-loop receptor channels.

Monepantel irreversibly binds to and opens Haemonchus contortus MPTL-1 and Caenorhabditis elegans ACR-20 receptors.

Structural analogues of the natural products magnolol and honokiol as potent allosteric potentiators of GABA(A) receptors.

A heteromeric potassium channel involved in the modulation of the plasma membrane potential is essential for the survival of African trypanosomes.

Trypanosoma brucei Bloodstream Forms Depend upon Uptake of myo-Inositol for Golgi Complex Phosphatidylinositol Synthesis and Normal Cell Growth.

Positive modulation of synaptic and extrasynaptic GABAA receptors by an antagonist of the high affinity benzodiazepine binding site.

Flagellar membranes are rich in raft-forming phospholipids.

Modulatory Effects of Eschscholzia californica Alkaloids on Recombinant GABAA Receptors.

Functional sites involved in modulation of the GABAA receptor channel by the intravenous anesthetics propofol, etomidate and pentobarbital.

A new chromanone derivative isolated from Hypericum lissophloeus (Hypericaceae) potentiates GABAA receptor currents in a subunit specific fashion.

Novel positive allosteric modulators of GABAA receptors with anesthetic activity.

Molecular mode of action of CGS 9895 at α1 β2 γ2 GABAA receptors.

Toward Understanding Functional Properties and Subunit Arrangement of α4β2δ γ-Aminobutyric Acid, Type A (GABAA) Receptors.