Keith Baar

Exercise induces an increase in muscle UCP3 as a component of the increase in mitochondrial biogenesis.

Response of rat muscle to acute resistance exercise defined by transcriptional and translational profiling.

Adaptations of skeletal muscle to exercise: rapid increase in the transcriptional coactivator PGC-1.

Skeletal muscle overexpression of nuclear respiratory factor 1 increases glucose transport capacity.

Engineering of functional tendon.

Involvement of PPAR gamma co-activator-1, nuclear respiratory factors 1 and 2, and PPAR alpha in the adaptive response to endurance exercise.

Rapid formation of functional muscle in vitro using fibrin gels.

Self-organization of rat cardiac cells into contractile 3-D cardiac tissue.

Development of a three-dimensional physiological model of the internal anal sphincter bioengineered in vitro from isolated smooth muscle cells.

New dimensions in tissue engineering: possible models for human physiology.

Cultured slow vs. fast skeletal muscle cells differ in physiology and responsiveness to stimulation.

Regional variation of tibialis anterior tendon mechanics is lost following denervation.

Activation of Akt as a potential mediator of adaptations that reduce muscle injury.

To perform your best: work hard not long.

Denervation does not change the ratio of collagen I and collagen III mRNA in the extracellular matrix of muscle.

Training for endurance and strength: lessons from cell signaling.

Resistance exercise, muscle loading/unloading and the control of muscle mass.

Myogenic gene expression signature establishes that brown and white adipocytes originate from distinct cell lineages.

Tendon mechanics: the argument heats up.

5-aminoimidazole-4-carboxamide 1-beta-D-ribofuranoside acutely stimulates skeletal muscle 2-deoxyglucose uptake in healthy men.

Engineered muscle: a tool for studying muscle physiology and function.

Muscle growth: no IGFs, ands, or buts.

Normal hypertrophy accompanied by phosphoryation and activation of AMP-activated protein kinase alpha1 following overload in LKB1 knockout mice.

Tension is required for fibripositor formation.

Small molecules can have big effects on endurance.

Engineering the bone-ligament interface using polyethylene glycol diacrylate incorporated with hydroxyapatite.

mVps34 is activated following high-resistance contractions.

Regulating fibrinolysis to engineer skeletal muscle from the C2C12 cell line.

The training stimulus experienced by the leg muscles during cycling in humans.

The signaling underlying FITness.

A novel bioreactor for stimulating skeletal muscle in vitro.

Training with low muscle glycogen enhances fat metabolism in well-trained cyclists.

The initiation of embryonic-like collagen fibrillogenesis by adult human tendon fibroblasts when cultured under tension.

Pyruvate suppresses PGC1alpha expression and substrate utilization despite increased respiratory chain content in C2C12 myotubes.

Factors affecting the longevity and strength in an in vitro model of the bone-ligament interface.

The unfolded protein response is activated in skeletal muscle by high-fat feeding: potential role in the downregulation of protein synthesis.

Prolonged activation of S6K1 does not suppress IRS or PI-3 kinase signaling during muscle cell differentiation.

Comments on Point:Counterpoint: IGF is/is not the major physiological regulator of muscle mass. Irrelevant growth factor-I.

Engineering an in vitro model of a functional ligament from bone to bone.

A limited role for PI(3,4,5)P3 regulation in controlling skeletal muscle mass in response to resistance exercise.

Signals mediating skeletal muscle remodeling by resistance exercise: PI3-kinase independent activation of mTORC1.

Understanding the regulation of muscle plasticity.

Regulation of contractility and metabolic signaling by the β2-adrenergic receptor in rat ventricular muscle.

ER stress induces anabolic resistance in muscle cells through PKB-induced blockade of mTORC1.

Beneficial effects of resistance exercise on glycemic control are not further improved by protein ingestion.

The influence of carbohydrate-protein co-ingestion following endurance exercise on myofibrillar and mitochondrial protein synthesis.

Sirtuin 1 (SIRT1) deacetylase activity is not required for mitochondrial biogenesis or peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) deacetylation following endurance exercise.

The PGC-1α-related coactivator promotes mitochondrial and myogenic adaptations in C2C12 myotubes.

Optimizing an intermittent stretch paradigm using ERK1/2 phosphorylation results in increased collagen synthesis in engineered ligaments.

Sirt1 enhances skeletal muscle insulin sensitivity in mice during caloric restriction.

Defined electrical stimulation emphasizing excitability for the development and testing of engineered skeletal muscle.

Analysis of skeletal muscle hypertrophy in models of increased loading.

Altering endogenous carbohydrate availability to support training adaptations.

Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases.

More than a store: regulatory roles for glycogen in skeletal muscle adaptation to exercise.

Fine-tuning metabolism--how products of contraction regulate skeletal muscle adaptation.

Supplementation of a suboptimal protein dose with leucine or essential amino acids: effects on myofibrillar protein synthesis at rest and following resistance exercise in men.

The effect of growth factors on both collagen synthesis and tensile strength of engineered human ligaments.

Is irisin a human exercise gene?

Endurance training in mice increases the unfolded protein response induced by a high-fat diet.

Factors affecting the structure and maturation of human tissue engineered skeletal muscle.

Inhibition of myostatin signaling through Notch activation following acute resistance exercise.

The role of amino acids in skeletal muscle adaptation to exercise.

Maintenance of muscle mass and load-induced growth in Muscle RING Finger 1 null mice with age.

May the Force move you: TSC-ing the mechanical activation of mTOR.

Glycogen content regulates peroxisome proliferator activated receptor-∂ (PPAR-∂) activity in rat skeletal muscle.

Novel sorafenib-based structural analogues: in-vitro anticancer evaluation of t-MTUCB and t-AUCMB.

Compensatory regulation of HDAC5 in muscle maintains metabolic adaptive responses and metabolism in response to energetic stress.

Nutrition and the adaptation to endurance training.

Molecular brakes regulating mTORC1 activation in skeletal muscle following synergist ablation.

The effect of serum origin on tissue engineered skeletal muscle function.

Nutritional strategies to support concurrent training.

mTOR and the health benefits of exercise.

Pharmacology of manipulating lean body mass.

Streptomycin decreases the functional shift to a slow phenotype induced by electrical stimulation in engineered muscle.

Contractile and metabolic properties of engineered skeletal muscle derived from slow and fast phenotype mouse muscle.

Using molecular biology to maximize concurrent training.

Glucose concentration and streptomycin alter in vitro muscle function and metabolism.

The molecular basis for load-induced skeletal muscle hypertrophy.

Role of contraction duration in inducing fast-to-slow contractile and metabolic protein and functional changes in engineered muscle.

Effects of aging, exercise, and disease on force transfer in skeletal muscle.

Estrogen inhibits lysyl oxidase and decreases mechanical function in engineered ligaments.

Neuromuscular Junction Formation in Tissue-Engineered Skeletal Muscle Augments Contractile Function and Improves Cytoskeletal Organization.

Rapamycin does not prevent increases in myofibrillar or mitochondrial protein synthesis following endurance exercise.

The exercise-induced biochemical milieu enhances collagen content and tensile strength of engineered ligaments.

Bias is Stagnating Physiology.

Acute resistance exercise activates rapamycin-sensitive and -insensitive mechanisms that control translational activity and capacity in skeletal muscle.

Utilizing small nutrient compounds as enhancers of exercise-induced mitochondrial biogenesis.

Contribution of mechanical unloading to trabecular bone loss following non-invasive knee injury in mice.

Age-related deficits in skeletal muscle recovery following disuse are associated with neuromuscular junction instability and ER stress, not impaired protein synthesis.

Age-related Differences in Dystrophin: Impact on Force Transfer Proteins, Membrane Integrity, and Neuromuscular Junction Stability.

Disruption of the Class IIa HDAC Corepressor Complex Increases Energy Expenditure and Lipid Oxidation.

Factors That Affect Tissue-Engineered Skeletal Muscle Function and Physiology.

Vitamin C-enriched gelatin supplementation before intermittent activity augments collagen synthesis.

Minimizing Injury and Maximizing Return to Play: Lessons from Engineered Ligaments.

Muscle-specific and age-related changes in protein synthesis and protein degradation in response to hindlimb unloading in rats.

DNA-PK Promotes the Mitochondrial, Metabolic, and Physical Decline that Occurs During Aging.

Adaptations to Endurance and Strength Training.