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Department of Cell Biology and Histology
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4-HPR-mediated leukemia cell cytotoxicity is triggered by ceramide-induced mitochondrial oxidative stress and is regulated downstream by Bcl-2.
Free radical research May, 2007 | Pubmed ID: 17454142
Dihydroceramide desaturase activity is modulated by oxidative stress.
The Biochemical journal Mar, 2010 | Pubmed ID: 20105137
Terfenadine induces apoptosis and autophagy in melanoma cells through ROS-dependent and -independent mechanisms.
Apoptosis : an international journal on programmed cell death Dec, 2011 | Pubmed ID: 21861192
Evaluation of bioactive sphingolipids in 4-HPR-resistant leukemia cells.
BMC cancer Nov, 2011 | Pubmed ID: 22061047
Dihydroceramide accumulation and reactive oxygen species are distinct and nonessential events in 4-HPR-mediated leukemia cell death.
Biochemistry and cell biology = Biochimie et biologie cellulaire Apr, 2012 | Pubmed ID: 22428532
E2F2 and CREB cooperatively regulate transcriptional activity of cell cycle genes.
Nucleic acids research Dec, 2013 | Pubmed ID: 24038359
Cell-centric view of apoptosis and apoptotic cell death-inducing antitumoral strategies.
Cancers Mar, 2011 | Pubmed ID: 24212653
E2F7 regulates transcription and maturation of multiple microRNAs to restrain cell proliferation.
Nucleic acids research Mar, 2016 | Pubmed ID: 26961310
University of the Basque Country, UPV/EHU
Aintzane Apraiz*,1,
Jone Mitxelena*,2,3,
Ana Zubiaga2
1Department of Cell Biology and Histology, University of the Basque Country, UPV/EHU,
2Department of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country, UPV/EHU,
3Department of Molecular Mechanisms of Disease, University of Zurich
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