Charles Yanofsky

The anti-trp RNA-binding attenuation protein (Anti-TRAP), AT, recognizes the tryptophan-activated RNA binding domain of the TRAP regulatory protein.

Analysis of tryptophanase operon expression in vitro: accumulation of TnaC-peptidyl-tRNA in a release factor 2-depleted S-30 extract prevents Rho factor action, simulating induction.

Regulation by transcription attenuation in bacteria: how RNA provides instructions for transcription termination/antitermination decisions.

Instruction of translating ribosome by nascent peptide.

Zinc is required for assembly and function of the anti-trp RNA-binding attenuation protein, AT.

Using studies on tryptophan metabolism to answer basic biological questions.

Genomewide transcriptional changes associated with genetic alterations and nutritional supplementation affecting tryptophan metabolism in Bacillus subtilis.

Tandem transcription and translation regulatory sensing of uncharged tryptophan tRNA.

A transcriptional pause synchronizes translation with transcription in the tryptophanase operon leader region.

Rho's role in transcription attenuation in the tna operon of E. coli.

Features of a leader peptide coding region that regulate translation initiation for the anti-TRAP protein of B. subtilis.

The different roles of tryptophan transfer RNA in regulating trp operon expression in E. coli versus B. subtilis.

The favorable features of tryptophan synthase for proving Beadle and Tatum's one gene-one enzyme hypothesis.

Effects of tryptophan starvation on levels of the trp RNA-binding attenuation protein (TRAP) and anti-TRAP regulatory protein and their influence on trp operon expression in Bacillus subtilis.

An open letter to Elias Zerhouni.

Transcription attenuation: a highly conserved regulatory strategy used by bacteria.

Features of ribosome-peptidyl-tRNA interactions essential for tryptophan induction of tna operon expression.

Complexity in regulation of tryptophan biosynthesis in Bacillus subtilis.

Overexpression of tnaC of Escherichia coli inhibits growth by depleting tRNA2Pro availability.

Changes produced by bound tryptophan in the ribosome peptidyl transferase center in response to TnaC, a nascent leader peptide.

Ribosome recycling factor and release factor 3 action promotes TnaC-peptidyl-tRNA Dropoff and relieves ribosome stalling during tryptophan induction of tna operon expression in Escherichia coli.

Ribosomal features essential for tna operon induction: tryptophan binding at the peptidyl transferase center.

Establishing the triplet nature of the genetic code.

Comparison of tryptophan biosynthetic operon regulation in different Gram-positive bacterial species.

RNA-based regulation of genes of tryptophan synthesis and degradation, in bacteria.

Physiological effects of anti-TRAP protein activity and tRNA(Trp) charging on trp operon expression in Bacillus subtilis.

A genetic selection for Neurospora crassa mutants altered in their light regulation of transcription.

Evolution of bacterial trp operons and their regulation.

Conserved residues Asp16 and Pro24 of TnaC-tRNAPro participate in tryptophan induction of Tna operon expression.

Biochemical features and functional implications of the RNA-based T-box regulatory mechanism.

23S rRNA nucleotides in the peptidyl transferase center are essential for tryptophanase operon induction.

Tryptophan inhibits Proteus vulgaris TnaC leader peptide elongation, activating tna operon expression.

Positions of Trp codons in the leader peptide-coding region of the at operon influence anti-trap synthesis and trp operon expression in Bacillus licheniformis.

Regulation of transcription by unnatural amino acids.

Nascent polypeptide sequences that influence ribosome function.