Vadim Cherezov

Molecular organization of cholesterol in polyunsaturated membranes: microdomain formation.

Biophysical and transfection studies of the diC(14)-amidine/DNA complex.

Controlling membrane cholesterol content. A role for polyunsaturated (docosahexaenoate) phospholipids.

Too hot to handle? Synchrotron X-ray damage of lipid membranes and mesophases.

Membrane protein crystallization in meso: lipid type-tailoring of the cubic phase.

Interaction of cholesterol with a docosahexaenoic acid-containing phosphatidylethanolamine: trigger for microdomain/raft formation?

A robotic system for crystallizing membrane and soluble proteins in lipidic mesophases.

Rational design of lipid for membrane protein crystallization.

Order from disorder, corralling cholesterol with chaotic lipids. The role of polyunsaturated lipids in membrane raft formation.

Membrane protein crystallization in lipidic mesophases with tailored bilayers.

Room to move: crystallizing membrane proteins in swollen lipidic mesophases.

Molecular organization of cholesterol in unsaturated phosphatidylethanolamines: X-ray diffraction and solid state 2H NMR reveal differences with phosphatidylcholines.

Controlling the passage of light through metal microchannels by nanocoatings of phospholipids.

Crystallization and preliminary X-ray diffraction analysis of a soluble domain of the putative zinc transporter CzrB from Thermus thermophilus.

Membrane protein crystallization in lipidic mesophases. A mechanism study using X-ray microdiffraction.

GPCR engineering yields high-resolution structural insights into beta2-adrenergic receptor function.

High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor.

In meso crystal structure and docking simulations suggest an alternative proteoglycan binding site in the OpcA outer membrane adhesin.

A specific cholesterol binding site is established by the 2.8 A structure of the human beta2-adrenergic receptor.

Insights into the mode of action of a putative zinc transporter CzrB in Thermus thermophilus.

The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist.

LCP-FRAP Assay for Pre-Screening Membrane Proteins for in Meso Crystallization.

Analysis of full and partial agonists binding to beta2-adrenergic receptor suggests a role of transmembrane helix V in agonist-specific conformational changes.

Crystallizing membrane proteins using lipidic mesophases.

Rastering strategy for screening and centring of microcrystal samples of human membrane proteins with a sub-10 microm size X-ray synchrotron beam.

Nonlinear optical imaging of integral membrane protein crystals in lipidic mesophases.

LCP-Tm: an assay to measure and understand stability of membrane proteins in a membrane environment.

Recent progress in the structure determination of GPCRs, a membrane protein family with high potential as pharmaceutical targets.

Conserved binding mode of human beta2 adrenergic receptor inverse agonists and antagonist revealed by X-ray crystallography.

Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists.

Structure of the human dopamine D3 receptor in complex with a D2/D3 selective antagonist.

Structure of an agonist-bound human A2A adenosine receptor.

Development of an Automated High Throughput LCP-FRAP Assay to Guide Membrane Protein Crystallization in Lipid Mesophases.

Structure of the human histamine H1 receptor complex with doxepin.

Lipidic cubic phase technologies for membrane protein structural studies.

High resolution structure of the ba3 cytochrome c oxidase from Thermus thermophilus in a lipidic environment.

Characterization of lipid matrices for membrane protein crystallization by high-throughput small angle X-ray scattering.

Diversity and modularity of G protein-coupled receptor structures.

GPCR stabilization using the bicelle-like architecture of mixed sterol-detergent micelles.

Structure of the human κ-opioid receptor in complex with JDTic.

Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic.

Crystal structures of the outer membrane domain of intimin and invasin from enterohemorrhagic E. coli and enteropathogenic Y. pseudotuberculosis.

Fusion partner toolchest for the stabilization and crystallization of G protein-coupled receptors.

Structural basis for allosteric regulation of GPCRs by sodium ions.

Crystal Structure of a Voltage-gated K+ Channel Pore Module in a Closed State in Lipid Membranes.

Structure-function of the G protein-coupled receptor superfamily.

The GPCR Network: a large-scale collaboration to determine human GPCR structure and function.

Structural basis for molecular recognition at serotonin receptors.

Structural features for functional selectivity at serotonin receptors.

Towards protein-crystal centering using second-harmonic generation (SHG) microscopy.

Structure of the human smoothened receptor bound to an antitumour agent.

Hydrogen bonding of cholesterol in the lipidic cubic phase.

Integrated nonlinear optical imaging microscope for on-axis crystal detection and centering at a synchrotron beamline.

Structure of the human glucagon class B G-protein-coupled receptor.

Structure-based ligand discovery targeting orthosteric and allosteric pockets of dopamine receptors.

Structure of the CCR5 chemokine receptor-HIV entry inhibitor maraviroc complex.

The role of a sodium ion binding site in the allosteric modulation of the A(2A) adenosine G protein-coupled receptor.

Functional assay for T4 lysozyme-engineered G protein-coupled receptors with an ion channel reporter.

Serial femtosecond crystallography of G protein-coupled receptors.

Molecular control of δ-opioid receptor signalling.

Lipidic cubic phase injector facilitates membrane protein serial femtosecond crystallography.

Structure of a class C GPCR metabotropic glutamate receptor 1 bound to an allosteric modulator.

Structure of the human P2Y12 receptor in complex with an antithrombotic drug.

Allosteric sodium in class A GPCR signaling.

Agonist-bound structure of the human P2Y12 receptor.

Femtosecond crystallography of membrane proteins in the lipidic cubic phase.

Structural basis for Smoothened receptor modulation and chemoresistance to anticancer drugs.

Preparation of microcrystals in lipidic cubic phase for serial femtosecond crystallography.

Constitutive phospholipid scramblase activity of a G protein-coupled receptor.

Two classes of cholesterol binding sites for the β2AR revealed by thermostability and NMR.

Generic GPCR residue numbers - aligning topology maps while minding the gaps.

Structural biology. Crystal structure of the chemokine receptor CXCR4 in complex with a viral chemokine.

Structural basis for bifunctional peptide recognition at human δ-opioid receptor.

GPCR structure, function, drug discovery and crystallography: report from Academia-Industry International Conference (UK Royal Society) Chicheley Hall, 1-2 September 2014.

Two disparate ligand-binding sites in the human P2Y1 receptor.

Lipidic cubic phase serial millisecond crystallography using synchrotron radiation.

Structure of the Angiotensin receptor revealed by serial femtosecond crystallography.

Fluorescence Recovery After Photobleaching in Lipidic Cubic Phase (LCP-FRAP): A Precrystallization Assay for Membrane Proteins.

A novel inert crystal delivery medium for serial femtosecond crystallography.

Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser.

Serial femtosecond crystallography of soluble proteins in lipidic cubic phase.

Structural Basis for Ligand Recognition and Functional Selectivity at Angiotensin Receptor.

The Importance of Ligand-Receptor Conformational Pairs in Stabilization: Spotlight on the N/OFQ G Protein-Coupled Receptor.

The Fragment Molecular Orbital Method Reveals New Insight into the Chemical Nature of GPCR-Ligand Interactions.

Ternary structure reveals mechanism of a membrane diacylglycerol kinase.

Serial femtosecond X-ray diffraction of enveloped virus microcrystals.

X-ray laser diffraction for structure determination of the rhodopsin-arrestin complex.

Serial femtosecond crystallography datasets from G protein-coupled receptors.

Serial Femtosecond Crystallography of Membrane Proteins.