Walter N. Hittelman

Genetic instability in epithelial tissues at risk for cancer.

Biologic correlates of a biochemoprevention trial in advanced upper aerodigestive tract premalignant lesions.

Paclitaxel induces inactivation of p70 S6 kinase and phosphorylation of Thr421 and Ser424 via multiple signaling pathways in mitosis.

Improvement and application of fluorescence inter-simple sequence repeat polymerase chain reaction for the study of subclonal growths in lung epithelial cell populations.

Disruption of the Rad9/Rad1/Hus1 (9-1-1) complex leads to checkpoint signaling and replication defects.

Deficiency of cell cycle checkpoints and DNA repair system predispose individuals to esophageal cancer.

Proliferative changes in the bronchial epithelium of former smokers treated with retinoids.

Characterization and mechanistic studies of a novel melanoma-targeting construct containing IκBa for specific inhibition of nuclear factor-κB activity.

Are cancer stem cells radioresistant?

Prevention of bronchial hyperplasia by EGFR pathway inhibitors in an organotypic culture model.

Development and characterization of a potent immunoconjugate targeting the Fn14 receptor on solid tumor cells.

Prevention of paclitaxel-induced neuropathy through activation of the central cannabinoid type 2 receptor system.

Programming in situ immunofluorescence intensities through interchangeable reactions of dynamic DNA complexes.

Construction and characterization of novel, completely human serine protease therapeutics targeting Her2/neu.

Antitumor activity of a humanized, bivalent immunotoxin targeting fn14-positive solid tumors.

The functionalized human serine protease granzyme B/VEGF₁₂₁ targets tumor vasculature and ablates tumor growth.

Antagonism of tumoral prolactin receptor promotes autophagy-related cell death.

MOF phosphorylation by ATM regulates 53BP1-mediated double-strand break repair pathway choice.

Pannexin-1 Up-regulation in the Dorsal Root Ganglion Contributes to Neuropathic Pain Development.

Chloride Homeostasis Critically Regulates Synaptic NMDA Receptor Activity in Neuropathic Pain.

Cell Cycle-Dependent Mechanisms Underlie Vincristine-Induced Death of Primary Acute Lymphoblastic Leukemia Cells.

Replication Stress Leading to Apoptosis within the S-phase Contributes to Synergism between Vorinostat and AZD1775 in HNSCC Harboring High-Risk TP53 Mutation.

Differentiation of Human Induced Pluripotent or Embryonic Stem Cells Decreases the DNA Damage Repair by Homologous Recombination.