Systems Biotechnology Research Center,
Gangneung Institute of Natural Products
Dr. Kyungsu Kang is a Senior Research Scientist at the Gangneung Institute of Natural Products, Korea Institute of Science and Technology (KIST) located in Gangwon-do, South Korea. He is also an Associate Professor in the Division of Bio-Medical Science & Technology, KIST School, Korea University of Science and Technology (UST), South Korea. He received his B.S. (in Applied Biology and Chemistry), M.S. and Ph.D. (in Agricultural Biotechnology) degrees from the College of Agriculture and Life Science, Seoul National University, South Korea.
During his early phase of graduate training, he studied agricultural plant biotechnology fields, such as plastid genetic transformation in the monocotyledonous plant rice and the biochemistry of herbicide target enzymes. During his Ph.D. studies, he investigated the pharmacological effects of natural products and elucidated the molecular mechanism underlying their biological activity, especially topoisomerase inhibition, anticancer efficacy, and side effects of various plant lignans. As a post-doctoral scientist in Prof. Michael Ristow’s laboratory at ETH Zürich (Swiss Federal Institute of Technology Zurich), Switzerland, Dr. Kang investigated the effect of plant flavonoid compounds on lifespan extension as well as their detailed cellular and biochemical mechanisms in the model animal Caenorhabditis elegans.
The main research topic of Dr. Kang’s laboratory is to discover bioactive natural products that can promote intestinal health and longevity. Dr. Kang and his members are interested in elucidating the biochemical and molecular mechanisms underlying the biological effects of various natural products. For this purpose, they are exploiting not only a tiny model nematode, Caenorhabditis elegans, but also cultured human and animal cells.
Plastid transformation in the monocotyledonous cereal crop, rice (Oryza sativa) and transmission of transgenes to their progeny.
Molecules and cells Jun, 2006 | Pubmed ID: 16819304
The chemopreventive effects of Saussurea salicifolia through induction of apoptosis and phase II detoxification enzyme.
Biological & pharmaceutical bulletin Dec, 2007 | Pubmed ID: 18057725
Tectoridin, a poor ligand of estrogen receptor alpha, exerts its estrogenic effects via an ERK-dependent pathway.
Molecules and cells Mar, 2009 | Pubmed ID: 19326083
The chemopreventive effects of Carpesium abrotanoides are mediated by induction of phase II detoxification enzymes and apoptosis in human colorectal cancer cells.
Journal of medicinal food Feb, 2010 | Pubmed ID: 20136434
Flow cytometric fluorescence pulse width analysis of etoposide-induced nuclear enlargement in HCT116 cells.
Biotechnology letters Aug, 2010 | Pubmed ID: 20429026
Lignans inhibit cell growth via regulation of Wnt/beta-catenin signaling.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association Aug-Sep, 2010 | Pubmed ID: 20510325
A polyacetylene from Gymnaster koraiensis exerts hepatoprotective effects in vivo and in vitro.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association Nov, 2010 | Pubmed ID: 20678536
Sulbutiamine counteracts trophic factor deprivation induced apoptotic cell death in transformed retinal ganglion cells.
Neurochemical research Nov, 2010 | Pubmed ID: 20809085
Hepatoprotective effect of flavonoid glycosides from Lespedeza cuneata against oxidative stress induced by tert-butyl hyperoxide.
Phytotherapy research : PTR Jul, 2011 | Pubmed ID: 21226126
Cell and nuclear enlargement of SW480 cells induced by a plant lignan, arctigenin: evaluation of cellular DNA content using fluorescence microscopy and flow cytometry.
DNA and cell biology Aug, 2011 | Pubmed ID: 21663531
Isolation of phlorotannins from Eisenia bicyclis and their hepatoprotective effect against oxidative stress induced by tert-butyl hyperoxide.
Applied biochemistry and biotechnology Nov, 2011 | Pubmed ID: 21892616
Youngia denticulata protects against oxidative damage induced by tert-butylhydroperoxide in HepG2 cells.
Journal of medicinal food Oct, 2011 | Pubmed ID: 21895413
A novel topoisomerase inhibitor, daurinol, suppresses growth of HCT116 cells with low hematological toxicity compared to etoposide.
Neoplasia (New York, N.Y.) Nov, 2011 | Pubmed ID: 22131880
Dibenzocyclooctadiene lignans, gomisins J and N inhibit the Wnt/β-catenin signaling pathway in HCT116 cells.
Biochemical and biophysical research communications Nov, 2012 | Pubmed ID: 23085047
Nuclear factor-E2 (Nrf2) is regulated through the differential activation of ERK1/2 and PKC α/βII by Gymnasterkoreayne B.
Cancer letters Apr, 2013 | Pubmed ID: 23219897
Protective effect of Paeonia anomala extracts and constituents against tert-butylhydroperoxide-induced oxidative stress in HepG2 cells.
Planta medica Jan, 2013 | Pubmed ID: 23349023
Bifunctional chemopreventive effects of Adenocaulon himalaicum through induction of detoxification enzymes and apoptosis.
Journal of medicinal food Aug, 2013 | Pubmed ID: 23957354
Antioxidant activity of phenolics in leaves of three red pepper (Capsicum annuum) cultivars.
Journal of agricultural and food chemistry Jan, 2014 | Pubmed ID: 24087837
Gymnaster koraiensis and its major components, 3,5-di-O-caffeoylquinic acid and gymnasterkoreayne B, reduce oxidative damage induced by tert-butyl hydroperoxide or acetaminophen in HepG2 cells.
BMB reports Oct, 2013 | Pubmed ID: 24148773
Secretome profiling reveals the signaling molecules of apoptotic HCT116 cells induced by the dietary polyacetylene gymnasterkoreayne B.
Journal of agricultural and food chemistry Mar, 2014 | Pubmed ID: 24571669
Apigenin isolated from Daphne genkwa Siebold et Zucc. inhibits 3T3-L1 preadipocyte differentiation through a modulation of mitotic clonal expansion.
Life sciences Apr, 2014 | Pubmed ID: 24582594
Crepidiastrum denticulatum extract protects the liver against chronic alcohol-induced damage and fat accumulation in rats.
Journal of medicinal food Apr, 2014 | Pubmed ID: 24650230
Daurinol, a catalytic inhibitor of topoisomerase IIα, suppresses SNU-840 ovarian cancer cell proliferation through cell cycle arrest in S phase.
International journal of oncology Aug, 2014 | Pubmed ID: 24841075
Daurinol Enhances the Efficacy of Radiotherapy in Lung Cancer via Suppression of Aurora Kinase A/B Expression.
Molecular cancer therapeutics Jul, 2015 | Pubmed ID: 25882311
Isolation of major phenolics from Launaea spinosa and their protective effect on HepG2 cells damaged with t-BHP.
Pharmaceutical biology , 2016 | Pubmed ID: 26052623
Identification of dialkyl diacetylene diols with potent cancer chemopreventive activity.
Bioorganic & medicinal chemistry letters Sep, 2015 | Pubmed ID: 26253633
Direct analysis of prostaglandin-E2 and -D2 produced in an inflammatory cell reaction and its application for activity screening and potency evaluation using turbulent flow chromatography liquid chromatography-high resolution mass spectrometry.
Journal of chromatography. A Sep, 2016 | Pubmed ID: 27524299
Toxicological evaluation of the topoisomerase inhibitor, etoposide, in the model animal Caenorhabditis elegans and 3T3-L1 normal murine cells.
Environmental toxicology Jun, 2017 | Pubmed ID: 28206703
AKR1B10-inhibitory Selaginella tamariscina extract and amentoflavone decrease the growth of A549 human lung cancer cells in vitro and in vivo.
Journal of ethnopharmacology Apr, 2017 | Pubmed ID: 28286104
Data on the anti-tumor effects of Selaginella tamariscina extract and amentoflavone combined with doxorubicin in mice.
Data in brief Aug, 2017 | Pubmed ID: 28603761
High-throughput and direct measurement of androgen levels using turbulent flow chromatography liquid chromatography-triple quadrupole mass spectrometry (TFC-LC-TQMS) to discover chemicals that modulate dihydrotestosterone production in human prostate cancer cells.
Biotechnology letters Feb, 2018 | Pubmed ID: 29164416
Effects of fermented milk treatment on microbial population and metabolomic outcomes in a three-stage semi-continuous culture system.
Food chemistry Oct, 2018 | Pubmed ID: 29784310
Anti-Obesity Effect of Standardized Extract of Microalga Containing Fucoxanthin.
Marine drugs May, 2019 | Pubmed ID: 31137922
3,3'-Diindolylmethane Improves Intestinal Permeability Dysfunction in Cultured Human Intestinal Cells and the Model Animal .
Journal of agricultural and food chemistry Aug, 2019 | Pubmed ID: 31353906
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