Julia Ladewig

Institute of Reconstructive Neurobiology

University of Bonn

BIOGRAPHY

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PUBLICATIONS

Lineage selection of functional and cryopreservable human embryonic stem cell-derived neurons.

Stem cells (Dayton, Ohio) Jul, 2008 | Pubmed ID: 18420830

A rosette-type, self-renewing human ES cell-derived neural stem cell with potential for in vitro instruction and synaptic integration.

Proceedings of the National Academy of Sciences of the United States of America Mar, 2009 | Pubmed ID: 19218428

Excitation-induced ataxin-3 aggregation in neurons from patients with Machado-Joseph disease.

Nature Nov, 2011 | Pubmed ID: 22113611

Capture of neuroepithelial-like stem cells from pluripotent stem cells provides a versatile system for in vitro production of human neurons.

PloS one , 2012 | Pubmed ID: 22272239

Small molecules enable highly efficient neuronal conversion of human fibroblasts.

Nature methods Jun, 2012 | Pubmed ID: 22484851

Presenilin-1 L166P mutant human pluripotent stem cell-derived neurons exhibit partial loss of γ-secretase activity in endogenous amyloid-β generation.

The American journal of pathology Jun, 2012 | Pubmed ID: 22510327

Leveling Waddington: the emergence of direct programming and the loss of cell fate hierarchies.

Nature reviews. Molecular cell biology Apr, 2013 | Pubmed ID: 23486282

Embryonic stem cell-based modeling of tau pathology in human neurons.

The American journal of pathology May, 2013 | Pubmed ID: 23499461

Leveling Waddington: the emergence of direct programming and the loss of cell fate hierarchies.

Nature reviews. Molecular cell biology Apr, 2013 | Pubmed ID: 23847783

Auto-attraction of neural precursors and their neuronal progeny impairs neuronal migration.

Nature neuroscience Jan, 2014 | Pubmed ID: 24241396

APP processing in human pluripotent stem cell-derived neurons is resistant to NSAID-based γ-secretase modulation.

Stem cell reports , 2013 | Pubmed ID: 24371804

Arylsulfatase A Overexpressing Human iPSC-derived Neural Cells Reduce CNS Sulfatide Storage in a Mouse Model of Metachromatic Leukodystrophy.

Molecular therapy : the journal of the American Society of Gene Therapy Sep, 2015 | Pubmed ID: 26061647

Modeling CNS Development and Disease.

Stem cells international , 2016 | Pubmed ID: 27642304

An Organoid-Based Model of Cortical Development Identifies Non-Cell-Autonomous Defects in Wnt Signaling Contributing to Miller-Dieker Syndrome.

Cell reports Apr, 2017 | Pubmed ID: 28380362

A Little Bit of Guidance: Mini Brains on Their Route to Adolescence.

Cell stem cell Aug, 2017 | Pubmed ID: 28777940

INSTITUTIONS

University of Bonn

JOVE ARTICLES

Generation of Standardized and Reproducible Forebrain-type Cerebral Organoids from Human Induced Pluripotent Stem Cells

Olivia Krefft^*,1,

Ammar Jabali^*,1,

Vira Iefremova¹,

Philipp Koch^1,2,3,

Julia Ladewig¹

¹Institute of Reconstructive Neurobiology, University of Bonn,

²Central Institute of Mental Health, University of Heidelberg/Medical Faculty Mannheim,

³, Hector Institute for Translational Brain Research (HITBR gGmbH)

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Julia Ladewig

.css-o250i3{font-size:18px;font-family:Open Sans,sans-serif;line-height:21.6px;}Institute of Reconstructive Neurobiology

University of Bonn

Generation of Standardized and Reproducible Forebrain-type Cerebral Organoids from Human Induced Pluripotent Stem Cells

Institute of Reconstructive Neurobiology