noninvasive-high-throughput-determination-of-sleep-duration-in-rodents

Noninvasive, High-throughput Determination of Sleep Duration in Rodents

Traditionally, sleep is monitored by an electroencephalogram (EEG). EEG studies in rodents require surgical implantation of the electrodes followed by a ...

quantitative-autoradiographic-method-for-determination-regional-rates

Quantitative Autoradiographic Method for Determination of Regional Rates of Cerebral Protein Synthesis In Vivo

Protein synthesis is required for development and maintenance of neuronal function and is involved in adaptive changes in the nervous system. Moreover, it ...

National Institutes of Health

In patients with fragile X syndrome (FXS), sleep problems are commonly observed but are not well characterized. In animal models of FXS ( and  knockout (KO)/ heterozygote) circadian rhythmicity is affected, but sleep  has not been examined. We used a home-cage monitoring system to assess total sleep time in both light and dark phases in  KO mice at different developmental stages.  KOs at P21 do not differ from controls, but genotype × phase interactions in both adult (P70 and P180) groups are statistically significant indicating that sleep in  KOs is reduced selectively in the light phase compared to controls. Our results show the emergence of abnormal sleep in  KOs during the later stages of brain maturation. Treatment of adult  KO mice with a GABA agonist, R-baclofen, did not restore sleep duration in the light phase. In adult (P70)  KO heterozygote animals, total sleep time was further reduced, once again in the light phase. Our data highlight the importance of the fragile X genes ( and ) in sleep physiology and confirm the utility of these mouse models in enhancing our understanding of sleep disorders in FXS.

Deficient Sleep in Mouse Models of Fragile X Syndrome.

Exposure to the arts is vital to our quality of life, providing opportunities for social connection, engagement with past hobbies and perhaps most essentially in providing the potential for enhanced means of expression. For individuals with dementia and their care-givers, access to the arts can be challenging.

Article Total : 2	Year
Publication title	2018
Publication title	2019

Article	Year
Deficient Sleep in Mouse Models of Fragile X Syndrome. Frontiers in molecular neuroscience\| PubMed ID: 28919851	2017
Lincoln center moments: integrating accessibility and enhancement through expanding performing arts experiences. Arts & health\| PubMed ID: 31038421	2019

Anita Torossian

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