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Department of Biological Chemistry
Heather R. Christofk has not added Biography.
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New aspects of the Warburg effect in cancer cell biology.
Seminars in cell & developmental biology Jun, 2012 | Pubmed ID: 22406683
Histone acetylation regulates intracellular pH.
Molecular cell Jan, 2013 | Pubmed ID: 23201122
Metabolomics strategy reveals subpopulation of liposarcomas sensitive to gemcitabine treatment.
Cancer discovery Dec, 2012 | Pubmed ID: 23230188
Novel dedifferentiated liposarcoma xenograft models reveal PTEN down-regulation as a malignant signature and response to PI3K pathway inhibition.
The American journal of pathology Apr, 2013 | Pubmed ID: 23416162
An essential requirement for the SCAP/SREBP signaling axis to protect cancer cells from lipotoxicity.
Cancer research May, 2013 | Pubmed ID: 23440422
EGFR Mutation-Induced Alternative Splicing of Max Contributes to Growth of Glycolytic Tumors in Brain Cancer.
Cell metabolism May, 2013 | Pubmed ID: 23707073
Doxycycline alters metabolism and proliferation of human cell lines.
PloS one , 2013 | Pubmed ID: 23741339
Adenovirus E4ORF1-induced MYC activation promotes host cell anabolic glucose metabolism and virus replication.
Cell metabolism Apr, 2014 | Pubmed ID: 24703700
The metabolic milieu of metastases.
Cell Jan, 2015 | Pubmed ID: 25635452
2-Hydroxyglutarate Inhibits ATP Synthase and mTOR Signaling.
Cell metabolism Sep, 2015 | Pubmed ID: 26190651
MYC-induced reprogramming of glutamine catabolism supports optimal virus replication.
Nature communications Nov, 2015 | Pubmed ID: 26561297
MCT1 Modulates Cancer Cell Pyruvate Export and Growth of Tumors that Co-express MCT1 and MCT4.
Cell reports Feb, 2016 | Pubmed ID: 26876179
Asparagine promotes cancer cell proliferation through use as an amino acid exchange factor.
Nature communications Apr, 2016 | Pubmed ID: 27126896
Glycolytic Metabolism Plays a Functional Role in Regulating Human Pluripotent Stem Cell State.
Cell stem cell 10, 2016 | Pubmed ID: 27618217
Targeted Inhibition of EGFR and Glutaminase Induces Metabolic Crisis in EGFR Mutant Lung Cancer.
Cell reports 01, 2017 | Pubmed ID: 28099841
Recurrent patterns of DNA copy number alterations in tumors reflect metabolic selection pressures.
Molecular systems biology 02, 2017 | Pubmed ID: 28202506
mTORC2 Regulates Amino Acid Metabolism in Cancer by Phosphorylation of the Cystine-Glutamate Antiporter xCT.
Molecular cell Jul, 2017 | Pubmed ID: 28648777
The GSK3 Signaling Axis Regulates Adaptive Glutamine Metabolism in Lung Squamous Cell Carcinoma.
Cancer cell May, 2018 | Pubmed ID: 29763624
David Geffen School of Medicine
UCLA
David Jelinek1,2,
Aimee Flores1,3,
Melanie Uebelhoer1,
Vincent Pasque2,
Kathrin Plath2,3,
M. Luisa Iruela-Arispe1,3,
Heather R. Christofk2,3,
William E. Lowry1,3,
Hilary A. Coller1,2,3
1Department of Molecular, Cell and Developmental Biology, UCLA,
2Department of Biological Chemistry, David Geffen School of Medicine,
3Molecular Biology Institute Interdepartmental Program, UCLA
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