Scott Diamond

Adenovirus or HA-2 fusogenic peptide-assisted lipofection increases cytoplasmic levels of plasmid in nondividing endothelium with little enhancement of transgene expression.

Comparison of PSGL-1 microbead and neutrophil rolling: microvillus elongation stabilizes P-selectin bond clusters.

Endovascular microcoil gene delivery using immobilized anti-adenovirus antibody for vector tethering.

Selectin-like kinetics and biomechanics promote rapid platelet adhesion in flow: the GPIb(alpha)-vWF tether bond.

Adhesion of normal erythrocytes at depressed venous shear rates to activated neutrophils, activated platelets, and fibrin polymerized from plasma.

Neutrophil cathepsin G promotes prothrombinase and fibrin formation under flow conditions by activating fibrinogen-adherent platelets.

Shear stress causes nuclear localization of endothelial glucocorticoid receptor and expression from the GRE promoter.

Alterations in the intrinsic properties of the GPIbalpha-VWF tether bond define the kinetics of the platelet-type von Willebrand disease mutation, Gly233Val.

The epithelial-specific ETS transcription factor ESX/ESE-1/Elf-3 modulates breast cancer-associated gene expression.

Printing chemical libraries on microarrays for fluid phase nanoliter reactions.

Vascular injuries to the extremities in a suburban trauma center.

Surfactants attenuate gas embolism-induced thrombin production.

Exogenous nitric oxide activates the endothelial glucocorticoid receptor.

Mouse embryonic stem cells efficiently lipofected with nuclear localization peptide result in a high yield of chimeric mice and retain germline transmission potency.

Blood coagulation kinetics: high throughput method for real-time reaction monitoring.

Use of D-dimer to aid in excluding deep venous thrombosis in ambulatory patients.

High throughput substrate specificity profiling of serine and cysteine proteases using solution-phase fluorogenic peptide microarrays.

Profiling serine protease substrate specificity with solution phase fluorogenic peptide microarrays.

Nanoliter homogenous ultra-high throughput screening microarray for lead discoveries and IC50 profiling.

Inhibitors of cathepsin L prevent severe acute respiratory syndrome coronavirus entry.

Targeting viral-mediated transduction to the lung airway epithelium with the anti-inflammatory cationic lipid dexamethasone-spermine.

Fibrin affinity of erythrocyte-coupled tissue-type plasminogen activators endures hemodynamic forces and enhances fibrinolysis in vivo.

Microarrays for the functional analysis of the chemical-kinase interactome.

Stochastic modeling of blood coagulation initiation.

Functional phenotyping of human plasma using a 361-fluorogenic substrate biosensing microarray.

Photocleavage of o-nitrobenzyl ether derivatives for rapid biomedical release applications.

Matrix protein microarrays for spatially and compositionally controlled microspot thrombosis under laminar flow.

Controlled release of DNA/polyamine complex by photoirradiation of a solid phase presenting o-nitrobenzyl ether tethered spermine or polyethyleneimine.

Differential utilization of transcription activation subdomains by distinct coactivators regulates Pit-1 basal and Ras responsiveness.

Methods for mapping protease specificity.

Synthesis and structure-activity relationships of a series of increasingly hydrophobic cationic steroid lipofection reagents.

Biotinylated photocleavable polyethylenimine: capture and triggered release of nucleic acids from solid supports.

Identification and characterization of 3-substituted pyrazolyl esters as alternate substrates for cathepsin B: the confounding effects of DTT and cysteine in biological assays.

A Saccharomyces cerevisiae cell-based quantitative beta-galactosidase assay compatible with robotic handling and high-throughput screening.

Identification and synthesis of a unique thiocarbazate cathepsin L inhibitor.

Determination of surface tissue factor thresholds that trigger coagulation at venous and arterial shear rates: amplification of 100 fM circulating tissue factor requires flow.

Hemodynamic regulation of inflammation at the endothelial-neutrophil interface.

Harry L. Goldsmith, Ph.d.

Kinetic characterization and molecular docking of a novel, potent, and selective slow-binding inhibitor of human cathepsin L.

A membrane-based microfluidic device for controlling the flux of platelet agonists into flowing blood.

Design, synthesis, and evaluation of inhibitors of cathepsin L: Exploiting a unique thiocarbazate chemotype.

Proteases' prime targets revealed.

Evaluation of an orthogonal pooling strategy for rapid high-throughput screening of proteases.

A molecular signaling model of platelet phosphoinositide and calcium regulation during homeostasis and P2Y1 activation.

Molecular docking of cathepsin L inhibitors in the binding site of papain.

RNA interference screen to identify pathways that enhance or reduce nonviral gene transfer during lipofection.

Ethanol enhances neutrophil membrane tether growth and slows rolling on P-selectin but reduces capture from flow and firm arrest on IL-1-treated endothelium.

High-throughput screening for modulators of mesenchymal stem cell chondrogenesis.

Toward the development of a potent and selective organoruthenium mammalian sterile 20 kinase inhibitor.

Steady-state kinetic modeling constrains cellular resting states and dynamic behavior.

Lattice kinetic Monte Carlo simulations of convective-diffusive systems.

Disruption of SEMA4D ameliorates platelet hypersensitivity in dyslipidemia and confers protection against the development of atherosclerosis.

Cationic lipid formulations alter the in vivo tropism of AAV2/9 vector in lung.

Membrane cholesterol is a biomechanical regulator of neutrophil adhesion.

Discovery of chemical modulators of a conserved translational control pathway by parallel screening in yeast.

Bactericidal activities of the cationic steroid CSA-13 and the cathelicidin peptide LL-37 against Helicobacter pylori in simulated gastric juice.

From imide to lactam metallo-pyridocarbazoles: distinct scaffolds for the design of selective protein kinase inhibitors.

Molecular priming of Lyn by GPVI enables an immune receptor to adopt a hemostatic role.

Identification of triazinoindol-benzimidazolones as nanomolar inhibitors of the Mycobacterium tuberculosis enzyme TDP-6-deoxy-d-xylo-4-hexopyranosid-4-ulose 3,5-epimerase (RmlC).

Tissue factor activity under flow.

Combined antibacterial and anti-inflammatory activity of a cationic disubstituted dexamethasone-spermine conjugate.

Design, synthesis and biological evaluation of a library of thiocarbazates and their activity as cysteine protease inhibitors.

Cathepsin L occupies a vacuolar compartment and is a protein maturase within the endo/exocytic system of Toxoplasma gondii.

A small-molecule oxocarbazate inhibitor of human cathepsin L blocks severe acute respiratory syndrome and ebola pseudotype virus infection into human embryonic kidney 293T cells.

Discovery of potent small-molecule inhibitors of multidrug-resistant Plasmodium falciparum using a novel miniaturized high-throughput luciferase-based assay.

Pairwise agonist scanning predicts cellular signaling responses to combinatorial stimuli.

Novel cationic lipids with enhanced gene delivery and antimicrobial activity.

Identification of novel inhibitors of dietary lipid absorption using zebrafish.

High-throughput screening of a small molecule library for promoters and inhibitors of mesenchymal stem cell osteogenic differentiation.

RGS/Gi2alpha interactions modulate platelet accumulation and thrombus formation at sites of vascular injury.

Diminished contact-dependent reinforcement of Syk activation underlies impaired thrombus growth in mice lacking Semaphorin 4D.

Nanodroplet chemical microarrays and label-free assays.

Systems biology of coagulation initiation: kinetics of thrombin generation in resting and activated human blood.

The kinetics of αIIbβ3 activation determines the size and stability of thrombi in mice: implications for antiplatelet therapy.

A high-throughput multiplexed screening assay for optimizing serum-free differentiation protocols of human embryonic stem cells.

Simulation of aggregating particles in complex flows by the lattice kinetic Monte Carlo method.

Enhancers of adeno-associated virus AAV2 transduction via high throughput siRNA screening.

Novel high-throughput screen against Candida albicans identifies antifungal potentiators and agents effective against biofilms.

Identification of specific inhibitors of human RAD51 recombinase using high-throughput screening.

Relipidated tissue factor linked to collagen surfaces potentiates platelet adhesion and fibrin formation in a microfluidic model of vessel injury.

Small Molecule Inhibition of RISC Loading.

Drug discovery for Duchenne muscular dystrophy via utrophin promoter activation screening.