Yoshito Itoh

Transient biochemical response in interferon therapy decreases the development of hepatocellular carcinoma for five years and improves the long-term survival of chronic hepatitis C patients.

Detection of YMDD mutant using a novel sensitive method in chronic liver disease type B patients before and during lamivudine treatment.

Involvement of Kupffer cells in the interaction between neutrophils and sinusoidal endothelial cells in rats.

Activated Kupffer cells play an important role in intra-hepatic Th1-associated necro-inflammation in Concanavalin A-induced hepatic injury in mice.

Lamivudine therapy for Japanese patients with cirrhosis B.

Hepatitis B virus reactivation in a patient undergoing steroid-free chemotherapy.

Lack of evidence for leukocyte maternal microchimerism in primary biliary cirrhosis.

Clinical characteristics and prevalence of GB virus C, SEN virus, and HFE gene mutation in Japanese patients with nonalcoholic steatohepatitis.

Chemokine CCL20 enhances the growth of HuH7 cells via phosphorylation of p44/42 MAPK in vitro.

Characteristics of patients with chronic hepatitis C who develop hepatocellular carcinoma after a sustained response to interferon therapy.

PPARalpha ligands activate antioxidant enzymes and suppress hepatic fibrosis in rats.

Recurrence of hepatocellular carcinoma with rapid growth after spontaneous regression.

Tumor size-independence of telomere length indicates an aggressive feature of HCC.

In vivo expression patterns of survivin and its splicing variants in chronic liver disease and hepatocellular carcinoma.

Hepatitis B virus-related insertional mutagenesis in chronic hepatitis B patients as an early drastic genetic change leading to hepatocarcinogenesis.

Multifocal intraportal invasion of breast carcinoma diagnosed by laparoscopy-assisted liver biopsy.

A follow-up study to determine the value of liver biopsy and need for antiviral therapy for hepatitis C virus carriers with persistently normal serum aminotransferase.

Natural course of asymptomatic hepatitis C virus-infected patients and hepatocellular carcinoma after interferon therapy.

Premature telomere shortening and impaired regenerative response in hepatocytes of individuals with NAFLD.

Soluble TRAIL gene and actinomycin D synergistically suppressed multiple metastasis of TRAIL-resistant colon cancer in the liver.

Prediction of breakthrough hepatitis due to lamivudine-resistant hepatitis B virus by a sensitive semiquantitative assay using peptide nucleic acids.

Fenofibrate, a peroxisome proliferator-activated receptor alpha agonist, reduces hepatic steatosis and lipid peroxidation in fatty liver Shionogi mice with hereditary fatty liver.

[Role of oxidative stress in non-alcoholic steatohepatitis].

First phase viral kinetic parameters and prediction of response to interferon alpha-2b/ribavirin combination therapy in patients with chronic hepatitis C.

Role of cell-cycle turnover and oxidative stress in telomere shortening and cellular senescence in patients with chronic hepatitis C.

The severity of ultrasonographic findings in nonalcoholic fatty liver disease reflects the metabolic syndrome and visceral fat accumulation.

Evidence of oxidative stress as a cofactor in the development of insulin resistance in patients with chronic hepatitis C.

Guidelines for the antiviral therapy of hepatitis C virus carriers with normal serum aminotransferase based on platelet counts.

CREB3L4, INTS3, and SNAPAP are targets for the 1q21 amplicon frequently detected in hepatocellular carcinoma.

Activation of B-Myb by E2F1 in hepatocellular carcinoma.

ERK5 is a target for gene amplification at 17p11 and promotes cell growth in hepatocellular carcinoma by regulating mitotic entry.

A novel amplification target, ARHGAP5, promotes cell spreading and migration by negatively regulating RhoA in Huh-7 hepatocellular carcinoma cells.

Molecular characterization of a variant virus that caused de novo hepatitis B without elevation of hepatitis B surface antigen after chemotherapy with rituximab.

Analysis of hepatic genes involved in the metabolism of fatty acids and iron in nonalcoholic fatty liver disease.

Oxidative stress may enhance the malignant potential of human hepatocellular carcinoma by telomerase activation.

Steatosis and hepatic expression of genes regulating lipid metabolism in Japanese patients infected with hepatitis C virus.

Infrequent amplification of JUN in hepatocellular carcinoma.

PEG10 is a probable target for the amplification at 7q21 detected in hepatocellular carcinoma.

Blockade of interleukin-6 signaling enhances hepatic steatosis but improves liver injury in methionine choline-deficient diet-fed mice.

Nonalcoholic steatohepatitis and increased risk of chronic kidney disease.

SOX2 identified as a target gene for the amplification at 3q26 that is frequently detected in esophageal squamous cell carcinoma.

Detection of hepatitis C virus and antibodies in postmortem blood and bloodstains.

Simple formula to predict response to peginterferon alpha2b and ribavirin combination therapy in genotype 1 chronic hepatitis C patients with high viral loads.

Blockade of IL-6 signaling exacerbates liver injury and suppresses antiapoptotic gene expression in methionine choline-deficient diet-fed db/db mice.

Oxidative stress is closely associated with tumor angiogenesis of hepatocellular carcinoma.

High expression of p300 in HCC predicts shortened overall survival in association with enhanced epithelial mesenchymal transition of HCC cells.

Hepatic steatosis in chronic hepatitis C patients infected with genotype 2 is associated with insulin resistance, hepatic fibrosis and affects cumulative positivity of serum hepatitis C virus RNA in peginterferon and ribavirin combination therapy.

17β-Estradiol attenuates saturated fatty acid diet-induced liver injury in ovariectomized mice by up-regulating hepatic senescence marker protein-30.

[Treatment of difficult-to-treat chronic hepatitis B].

Validation of the FIB4 index in a Japanese nonalcoholic fatty liver disease population.

Fatty liver induced by free radicals and lipid peroxidation.

Treatment extension may benefit female genotype 1 chronic hepatitis C patients with complete early virological response to peginterferon-alpha-2b and ribavirin combination therapy.

Factors associated with the overall survival of elderly patients with hepatocellular carcinoma.

No association for Chinese HBV-related hepatocellular carcinoma susceptibility SNP in other East Asian populations.

Genome-wide association study confirming association of HLA-DP with protection against chronic hepatitis B and viral clearance in Japanese and Korean.

Prediction of a favorable clinical course in hepatitis C virus carriers with persistently normal serum alanine aminotransferase levels: A long-term follow-up study.

Rosuvastatin ameliorates high-fat and high-cholesterol diet-induced nonalcoholic steatohepatitis in rats.

Case of autoimmune hepatitis with markedly enlarged hepatoduodenal ligament lymph nodes.

Pathogenic Role of Iron Deposition in Reticuloendothelial Cells during the Development of Chronic Hepatitis C.

Aberrant expression of the gene in biliary tract cancer cells.

Prediction and treatment of difficult cases in colorectal endoscopic submucosal dissection.

In vivo imaging of intestinal helminths by capsule endoscopy.

The 'donations for decreased ALT (D4D)' prosocial behavior incentive scheme for NAFLD patients.

MDR1 is related to intestinal epithelial injury induced by acetylsalicylic acid.

Analysis of cardiopulmonary stress during endoscopy: is unsedated transnasal esophagogastroduodenoscopy appropriate for elderly patients?

Anti-inflammatory effects of carbon monoxide-releasing molecule on trinitrobenzene sulfonic acid-induced colitis in mice.

Phase I clinical trial of fibronectin CH296-stimulated T cell therapy in patients with advanced cancer.

New susceptibility and resistance HLA-DP alleles to HBV-related diseases identified by a trans-ethnic association study in Asia.

Efficacy and safety of sorafenib in very elderly patients aged 80 years and older with advanced hepatocellular carcinoma.

L-menthol improves adenoma detection rate during colonoscopy: a randomized trial.

Limitations of liver biopsy and non-invasive diagnostic tests for the diagnosis of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis.

Prevention of colonic spasm using L-menthol in colonoscopic examination.

[The technique and indication of endoscopic mucosal resection and endoscopic submucosal dissection].

The astaxanthin-induced improvement in lipid metabolism during exercise is mediated by a PGC-1α increase in skeletal muscle.

New genetic biomarkers predicting azathioprine blood concentrations in combination therapy with 5-aminosalicylic acid.

Blockade of interleukin 6 signalling ameliorates systemic insulin resistance through upregulation of glucose uptake in skeletal muscle and improves hepatic steatosis in high-fat diet fed mice.

Training methods and models for colonoscopic insertion, endoscopic mucosal resection, and endoscopic submucosal dissection.

Simple scoring system for predicting cirrhosis in nonalcoholic fatty liver disease.

The inhibitory effect of heat treatment against epithelial-mesenchymal transition (EMT) in human pancreatic adenocarcinoma cell lines.

Lower levels of insulin-like growth factor-1 standard deviation score are associated with histological severity of non-alcoholic fatty liver disease.

Predictors of malignancies and overall mortality in Japanese patients with biopsy-proven non-alcoholic fatty liver disease.

Serum alanine aminotransferase predicts the histological course of non-alcoholic steatohepatitis in Japanese patients.

Endoscopic mucosal resection for middle and large colorectal polyps with a double-loop snare.

Effect of PNPLA3 rs738409 variant (I148 M) on hepatic steatosis, necroinflammation, and fibrosis in Japanese patients with chronic hepatitis C.

Drug-induced liver injury in a chronic hepatitis C patient treated by peginterferon, ribavirin and simeprevir.

Risk of lens cloudiness during colorectal endoscopic submucosal dissection and ability of a novel lens cleaner to maintain and restore endoscopic view.

Helicobacter pylori infection might have a potential role in hepatocyte ballooning in nonalcoholic fatty liver disease.

Cytotoxic T lymphocyte-associated antigen 4 inhibition increases the antitumor activity of adoptive T-cell therapy when carried out with naïve rather than differentiated T cells.

Improvement in the visibility of colorectal polyps by using blue laser imaging (with video).

In Vivo Detection of Rat Colorectal Cancers by using a Dual-Wavelength Excitation Method.

Hypersensitivity Reactions to Oxaliplatin: Identifying the Risk Factors and Judging the Efficacy of a Desensitization Protocol.

EVI1, a target gene for amplification at 3q26, antagonizes transforming growth factor-β-mediated growth inhibition in hepatocellular carcinoma.

Tumor inoculation site affects the development of cancer cachexia and muscle wasting.

Adenoendocrine cell carcinoma of the gallbladder producing a high level of alpha-fetoprotein.

A novel noninvasive diagnostic method for nonalcoholic steatohepatitis using two glycobiomarkers.

Randomized comparison of daclatasvir + asunaprevir versus telaprevir + peginterferon/ribavirin in Japanese hepatitis C virus patients.

Phase I clinical trial of autologous NK cell therapy using novel expansion method in patients with advanced digestive cancer.

Rapamycin Improves Mortality Following Intestinal Ischemia-Reperfusion via the Inhibition of Remote Lung Inflammation in Mice.

High incidence of metachronous advanced adenoma and cancer after endoscopic resection of colon polyps ≥20 mm in size.

Hepatocellular carcinoma in Japanese patients with nonalcoholic fatty liver disease and alcoholic liver disease: multicenter survey.

The Impact of PNPLA3 rs738409 Genetic Polymorphism and Weight Gain ≥10 kg after Age 20 on Non-Alcoholic Fatty Liver Disease in Non-Obese Japanese Individuals.

Comparison of peg-interferon, ribavirin plus telaprevir vs simeprevir by propensity score matching.

Predictive factors for sorafenib-induced hand-foot skin reaction using ordered logistic regression analysis.

New-generation narrow band imaging improves visibility of polyps: a colonoscopy video evaluation study.

Association of coronary artery calcification with liver fibrosis in Japanese patients with non-alcoholic fatty liver disease.

Genome-wide DNA methylation analysis in hepatocellular carcinoma.

High incidence of postoperative hemorrhage in colorectal endoscopic submucosal dissection during anticoagulant therapy.

[Outcome and Problems of Nab-Paclitaxel Therapy for Gastric Cancer in Clinical Practice].

Understanding of HLA-conferred susceptibility to chronic hepatitis B infection requires HLA genotyping-based association analysis.

Multiple self-expandable metal stent deployment for unresectable malignant hilar biliary strictures: Combination of side-by-side and stent-in-stent methods.

p62, Upregulated during Preneoplasia, Induces Hepatocellular Carcinogenesis by Maintaining Survival of Stressed HCC-Initiating Cells.

Diagnostic ability of magnifying endoscopy with blue laser imaging for early gastric cancer: a prospective study.

Partially hydrolyzed guar gum enhances colonic epithelial wound healing via activation of RhoA and ERK1/2.

The amino acid-rich elemental diet Elental® preserves lean body mass during chemo- or chemoradiotherapy for esophageal cancer.

Current status and future prospects of chemotherapy for advanced hepatocellular carcinoma.

Circulating microRNA profiles in plasma: identification of miR-224 as a novel diagnostic biomarker in hepatocellular carcinoma independent of hepatic function.

Safety and Efficacy of a Same-Day Low-Volume 1 L PEG Bowel Preparation in Colonoscopy for the Elderly People and People with Renal Dysfunction.

Liver stiffness measurement to platelet ratio index predicts the stage of liver fibrosis in non-alcoholic fatty liver disease.

Linked color imaging improves endoscopic diagnosis of active Helicobacter pylori infection.

Butyrate and bioactive proteolytic form of Wnt-5a regulate colonic epithelial proliferation and spatial development.

Serum metabolomics analysis for early detection of colorectal cancer.

Blue Laser Imaging-Bright Improves Endoscopic Recognition of Superficial Esophageal Squamous Cell Carcinoma.

Development of hepatocellular carcinoma in Japanese patients with biopsy-proven non-alcoholic fatty liver disease: Association between PNPLA3 genotype and hepatocarcinogenesis/fibrosis progression.

The combination of elbasvir and grazoprevir for the treatment of chronic HCV infection in Japanese patients: a randomized phase II/III study.

Effect of 12-week dulaglutide therapy in Japanese patients with biopsy-proven non-alcoholic fatty liver disease and type 2 diabetes mellitus.

Effect of sodium glucose cotransporter 2 inhibitor on liver function tests in Japanese patients with non-alcoholic fatty liver disease and type 2 diabetes mellitus.

Changes in Intestinal Motility and Gut Microbiota Composition in a Rat Stress Model.

Laparoscopic and endoscopic co-operative surgery for non-ampullary duodenal tumors.

Differences in Prevalence of Lymphovascular Invasion among Early Gastric Cancers between Korea and Japan.

The JAK/STAT pathway is involved in the upregulation of PD-L1 expression in pancreatic cancer cell lines.

Real-time monitoring of trans-epithelial electrical resistance in cultured intestinal epithelial cells: the barrier protection of water-soluble dietary fiber.

Histopathological analysis of cold snare polypectomy and its indication for colorectal polyps 10-14 mm in diameter.

Genome-Wide Association Study Identifies TLL1 Variant Associated With Development of Hepatocellular Carcinoma After Eradication of Hepatitis C Virus Infection.

Loss of PAR-3 protein expression is associated with invasion, lymph node metastasis, and poor survival in esophageal squamous cell carcinoma.

Lower blood pressure and risk of cisplatin nephrotoxicity: a retrospective cohort study.

Hepatic nucleotide binding oligomerization domain-like receptors pyrin domain-containing 3 inflammasomes are associated with the histologic severity of non-alcoholic fatty liver disease.

Early-Stage Gastric Cancer Can Be Found in Improved Atrophic Mucosa over Time from Successful Helicobacter pylori Eradication.

Assessment of Endoscopic Mucosal Healing of Ulcerative Colitis Using Linked Colour Imaging, a Novel Endoscopic Enhancement System.

ASPP2 suppresses invasion and TGF-β1-induced epithelial-mesenchymal transition by inhibiting Smad7 degradation mediated by E3 ubiquitin ligase ITCH in gastric cancer.

Mechanism of Human Influenza Virus RNA Persistence and Virion Survival in Feces: Mucus Protects Virions From Acid and Digestive Juices.

Secreted protein acidic and rich in cysteine functions in colitis via IL17A regulation in mucosal CD4 T cells.

Linked color imaging improves the visibility of colorectal polyps: a video study.

Tips for safety in endoscopic submucosal dissection for colorectal tumors.

Insulin resistance increases the risk of incident type 2 diabetes mellitus in patients with non-alcoholic fatty liver disease.

A Review of Non-operative Treatments for Hepatocellular Carcinoma with Advanced Portal Vein Tumor Thrombus.

Effects of canagliflozin, an SGLT2 inhibitor, on hepatic function in Japanese patients with type 2 diabetes mellitus: pooled and subgroup analyses of clinical trials.

EUS-guided antegrade stent placement for unresectable malignant hilar biliary strictures by use of a stent-in-stent method.

Linked color imaging improves the visibility of various featured colorectal polyps in an endoscopist's visibility and color difference value.

Combination of PNPLA3 and TLL1 polymorphism can predict advanced fibrosis in Japanese patients with nonalcoholic fatty liver disease.

Efficacy of glutathione for the treatment of nonalcoholic fatty liver disease: an open-label, single-arm, multicenter, pilot study.

Magnifying Endoscopy with Blue Laser Imaging Improves the Microstructure Visualization in Early Gastric Cancer: Comparison of Magnifying Endoscopy with Narrow-Band Imaging.

Real-world efficacy of daclatasvir and asunaprevir with respect to resistance-associated substitutions.

Rebamipide upregulates mucin secretion of intestinal goblet cells via Akt phosphorylation.

Viscosity is an important factor of resistance to alcohol-based disinfectants by pathogens present in mucus.

Efficacy of a Novel Narrow Knife with Water Jet Function for Colorectal Endoscopic Submucosal Dissection.

Detection of hepatitis B virus DNA and HBsAg from postmortem blood and bloodstains.

The protective effect of orally administered redox nanoparticle on intestinal ischemia-reperfusion injury in mice.

A novel lens cleaner to prevent water drop adhesions during colonoscopy and esophagogastroduodenoscopy.

Sorafenib versus Hepatic Arterial Infusion Chemotherapy as Initial Treatment for Hepatocellular Carcinoma with Advanced Portal Vein Tumor Thrombosis.

The NOX1 isoform of NADPH oxidase is involved in dysfunction of liver sinusoids in nonalcoholic fatty liver disease.

Ledipasvir-sofosbuvir for treating Japanese patients with chronic hepatitis C virus genotype 2 infection.

Development of a new ex vivo model for evaluation of endoscopic submucosal injection materials performance.

The influence of long-term use of proton pump inhibitors on the gut microbiota: an age-sex-matched case-control study.

Risk estimation model for nonalcoholic fatty liver disease in the Japanese using multiple genetic markers.

Phase I clinical trial of adoptive transfer of expanded natural killer cells in combination with IgG1 antibody in patients with gastric or colorectal cancer.

[The impact of direct-acting antiviral therapy on the diagnosis of hepatitis-C virus-associated hepatocellular carcinoma].

Stenotic Ischemic Enteritis with Concomitant Hepatic Portal Venous Gas and Pneumatosis Cystoides Intestinalis.

The genetic backgrounds in nonalcoholic fatty liver disease.

Selected reaction monitoring for colorectal cancer diagnosis using a set of five serum peptides identified by BLOTCHIP-MS analysis.

Mucus reduction promotes acetyl salicylic acid-induced small intestinal mucosal injury in rats.

A Diminutive T1 Cancer 4 mm in Size Resected by Cold Snare Polypectomy.

Impact of the Charlson comorbidity index and prognostic nutritional index on prognosis in patients with early gastric cancer after endoscopic submucosal dissection.

A circumferential rectal superficial neoplasm resected with endoscopic submucosal dissection using the pocket-creation method.

Correction: A novel lens cleaner to prevent water drop adhesions during colonoscopy and esophagogastroduodenoscopy.

Oncogenic miR-96-5p inhibits apoptosis by targeting the caspase-9 gene in hepatocellular carcinoma.

Carbon monoxide ameliorates murine T-cell-dependent colitis through the inhibition of Th17 differentiation.

The novel cutoff points for the FIB4 index categorized by age increase the diagnostic accuracy in NAFLD: a multi-center study.

Genome-wide association study identified new susceptible genetic variants in HLA class I region for hepatitis B virus-related hepatocellular carcinoma.

Correction to: The novel cutoff points for the FIB4 index categorized by age increase the diagnostic accuracy in NAFLD: a multi-center study.

Hepatic Arterial Infusion Chemotherapy: A Potential Therapeutic Option for Hepatocellular Carcinoma with Portal Vein Tumor Thrombus.

Differences in gut microbiota associated with age, sex, and stool consistency in healthy Japanese subjects.

Increase in the skeletal muscle mass to body fat mass ratio predicts the decline in transaminase in patients with nonalcoholic fatty liver disease.

Accuracy of non-invasive scoring systems for diagnosing non-alcoholic steatohepatitis-related fibrosis: Multicenter validation study.

Palmitate-induced lipotoxicity is crucial for the pathogenesis of nonalcoholic fatty liver disease in cooperation with gut-derived endotoxin.

The efficacy of the pocket-creation method for cases with severe fibrosis in colorectal endoscopic submucosal dissection.

Additional Thirty Seconds Observation with Linked Color Imaging Improves Detection of Missed Polyps in the Right-Sided Colon.

Colorectal endoscopic submucosal dissection for a lesion on the dentate line area resected with a scissor-type knife.

Blue laser imaging-bright improves real-time detection rate of early gastric cancer: a randomized controlled study.

Correction to: Differences in gut microbiota associated with age, sex, and stool consistency in healthy Japanese subjects.

Clinical and Pathological Challenges in the Diagnosis of Gastric-Type Differentiated Adenocarcinoma in the Stomach: A Study of Endoscopic Submucosal Dissection Cases.

High Enhancement Settings for White Light Observation Improves Colorectal Polyp Visibility in Color Difference Value and an Endoscopist's Visibility.

An Additional 30-s Observation of the Right-Sided Colon with Narrow Band Imaging Decreases Missed Polyps: A Pilot Study.