Toshiaki Kawakami

Bruton's tyrosine kinase regulates apoptosis and JNK/SAPK kinase activity.

Involvement of Bruton's tyrosine kinase in FcepsilonRI-dependent mast cell degranulation and cytokine production.

Terreic acid, a quinone epoxide inhibitor of Bruton's tyrosine kinase.

Regulation of protein kinase CbetaI by two protein-tyrosine kinases, Btk and Syk.

Akt-dependent cytokine production in mast cells.

PKCbeta modulates antigen receptor signaling via regulation of Btk membrane localization.

Regulation of mast-cell and basophil function and survival by IgE.

Protein kinase C beta (PKC beta): normal functions and diseases.

A Ras activation pathway dependent on Syk phosphorylation of protein kinase C.

Evidence that IgE molecules mediate a spectrum of effects on mast cell survival and activation via aggregation of the FcepsilonRI.

[Regulation of mast cell survival and activation by monomeric IgE].

Protein kinase C betaII regulates Akt phosphorylation on Ser-473 in a cell type- and stimulus-specific fashion.

Early divergence of Fc epsilon receptor I signals for receptor up-regulation and internalization from degranulation, cytokine production, and survival.

Critical role for galectin-3 in airway inflammation and bronchial hyperresponsiveness in a murine model of asthma.

IgE- and IgE+Ag-mediated mast cell migration in an autocrine/paracrine fashion.

Regulation of highly cytokinergic IgE-induced mast cell adhesion by Src, Syk, Tec, and protein kinase C family kinases.

Techniques to study Fc epsilonRI signaling.

Costimulation of mast cells by 4-1BB, a member of the tumor necrosis factor receptor superfamily, with the high-affinity IgE receptor.

Mast cell survival and activation by IgE in the absence of antigen: a consideration of the biologic mechanisms and relevance.

Positive and negative regulation of mast cell activation by Lyn via the FcepsilonRI.

Regulation of dendritic cell maturation and function by Bruton's tyrosine kinase via IL-10 and Stat3.

IgE regulation of mast cell survival and function.

Development, migration, and survival of mast cells.

Dysregulation of Src family kinases in mast cells from epilepsy-resistant ASK versus epilepsy-prone EL mice.

The Src family kinase Hck regulates mast cell activation by suppressing an inhibitory Src family kinase Lyn.

An improved mouse model of atopic dermatitis and suppression of skin lesions by an inhibitor of Tec family kinases.

Regulation of myeloproliferation and M2 macrophage programming in mice by Lyn/Hck, SHIP, and Stat5.

Pivotal advance: IgE accelerates in vitro development of mast cells and modifies their phenotype.

Allergen-independent immunomodulatory activities of immunoglobulin E.

Inhibition of NK cell activity by IL-17 allows vaccinia virus to induce severe skin lesions in a mouse model of eczema vaccinatum.

Polyclonal IgE induces mast cell survival and cytokine production.

Tumor suppression by phospholipase C-beta3 via SHP-1-mediated dephosphorylation of Stat5.

Small, mobile FcepsilonRI receptor aggregates are signaling competent.

Mast cells in atopic dermatitis.

A crucial door to the mast cell mystery knocked in.

A minor catalytic activity of Src family kinases is sufficient for maximal activation of mast cells via the high-affinity IgE receptor.

Lyn- and PLC-beta3-dependent regulation of SHP-1 phosphorylation controls Stat5 activity and myelomonocytic leukemia-like disease.

JNK1 controls mast cell degranulation and IL-1{beta} production in inflammatory arthritis.

Protective murine and human monoclonal antibodies against eczema vaccinatum.

Phospholipase C-β3 regulates FcɛRI-mediated mast cell activation by recruiting the protein phosphatase SHP-1.

Monomeric IgE and mast cell development, survival and function.

IgE stimulates human and mouse arterial cell apoptosis and cytokine expression and promotes atherogenesis in Apoe-/- mice.

Short Stat5-interacting peptide derived from phospholipase C-β3 inhibits hematopoietic cell proliferation and myeloid differentiation.

Regulation of proliferation, survival, differentiation, and activation by the Signaling Platform for SHP-1 phosphatase.

Histamine-releasing factor has a proinflammatory role in mouse models of asthma and allergy.

Human FcγRIIA at center stage.

A novel role for the transcription factor HIF-1α in the formation of mast cell extracellular traps.

Most Highly Cytokinergic IgEs Have Polyreactivity to Autoantigens.

Mast cells are required for full expression of allergen/SEB-induced skin inflammation.

Phospholipase C-β in immune cells.

Salmonella's masterful skill in mast cell suppression.

Histamine-releasing factor and immunoglobulins in asthma and allergy.

Critical role for mast cell Stat5 activity in skin inflammation.

Basic techniques to study FcεRI signaling in mast cells.

A mouse model of atopic dermatitis.

Signal transduction and chemotaxis in mast cells.

Mast cells and dendritic cells form synapses that facilitate antigen transfer for T cell activation.

Hypothetical Atopic Dermatitis-Myeloproliferative Neoplasm Syndrome.

Defective natural killer cell activity in a mouse model of eczema herpeticum.

Differentiate or die!

Skin microbiome promotes mast cell maturation by triggering stem cell factor production in keratinocytes.

Guanine nucleotide exchange factor RABGEF1 regulates keratinocyte-intrinsic signaling to maintain skin homeostasis.

From IgE to Omalizumab.

Role of Histamine-releasing Factor in Allergic Inflammatory Reactions.

TWEAK mediates inflammation in experimental atopic dermatitis and psoriasis.

Histamine-releasing factor enhances food allergy.

Crystal structures of murine and human Histamine-Releasing Factor (HRF/TCTP) and a model for HRF dimerisation in mast cell activation.

LIGHT-HVEM signaling in keratinocytes controls development of dermatitis.

PAI1 mediates fibroblast-mast cell interactions in skin fibrosis.

Kimishige Ishizaka 1925-2018.