Peter Besmer

Developmental Biology Program, Memorial Sloan Kettering Cancer Center

Affiliated withMemorial Sloan Kettering Cancer Center

Research Area

Biology

Biography

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JoVE Journal Publications

Article Total : 1	Year
Publication title	2011

Other Publications

Article	Year
Avian bic, a gene isolated from a common retroviral site in avian leukosis virus-induced lymphomas that encodes a noncoding RNA, cooperates with c-myc in lymphomagenesis and erythroleukemoge... Journal of virology\| PubMed ID: 11932393	2002
Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kit-ligand. Cell\| PubMed ID: 12062105	2002
Gastrointestinal stromal tumors in a mouse model by targeted mutation of the Kit receptor tyrosine kinase. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12754375	2003
A role for kit receptor signaling in Leydig cell steroidogenesis. Biology of reproduction\| PubMed ID: 12773427	2003
Association of KIT exon 9 mutations with nongastric primary site and aggressive behavior: KIT mutation analysis and clinical correlates of 120 gastrointestinal stromal tumors. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 12960119	2003
Pleomorphic characteristics of a germ-line KIT mutation in a large kindred with gastrointestinal stromal tumors, hyperpigmentation, and dysphagia. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 14977822	2004
Critical role for Kit-mediated Src kinase but not PI 3-kinase signaling in pro T and pro B cell development. The Journal of experimental medicine\| PubMed ID: 15024050	2004
Gene expression in gastrointestinal stromal tumors is distinguished by KIT genotype and anatomic site. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 15161681	2004
Multiple gastrointestinal stromal tumors in type I neurofibromatosis: a pathologic and molecular study. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc\| PubMed ID: 15540118	2005
Gastrointestinal stromal tumors in children and young adults: a clinicopathologic, molecular, and genomic study of 15 cases and review of the literature. Journal of pediatric hematology/oncology\| PubMed ID: 15838387	2005
Acquired resistance to imatinib in gastrointestinal stromal tumor occurs through secondary gene mutation. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 15930355	2005
Extracellular KIT receptor mutants, commonly found in core binding factor AML, are constitutively active and respond to imatinib mesylate. Blood\| PubMed ID: 16081693	2005
Lyn kinase promotes erythroblast expansion and late-stage development. Blood\| PubMed ID: 16705093	2006
A distant upstream locus control region is critical for expression of the Kit receptor gene in mast cells. Molecular and cellular biology\| PubMed ID: 16847336	2006
The scaffolding adapter Gab2, via Shp-2, regulates kit-evoked mast cell proliferation by activating the Rac/JNK pathway. The Journal of biological chemistry\| PubMed ID: 16873377	2006
Oncogenic Kit signaling and therapeutic intervention in a mouse model of gastrointestinal stromal tumor. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16908864	2006
Comparative ultrastructural analysis and KIT/PDGFRA genotype in 125 gastrointestinal stromal tumors. Ultrastructural pathology\| PubMed ID: 17182437	2006
Pathologic and molecular heterogeneity in imatinib-stable or imatinib-responsive gastrointestinal stromal tumors. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 17200352	2007
Different ADAMs have distinct influences on Kit ligand processing: phorbol-ester-stimulated ectodomain shedding of Kitl1 by ADAM17 is reduced by ADAM19. Journal of cell science\| PubMed ID: 17344430	2007
Histone H2AX is a mediator of gastrointestinal stromal tumor cell apoptosis following treatment with imatinib mesylate. Cancer research\| PubMed ID: 17363589	2007
L576P KIT mutation in anal melanomas correlates with KIT protein expression and is sensitive to specific kinase inhibition. International journal of cancer. Journal international du cancer\| PubMed ID: 17372901	2007
Sorafenib inhibits the imatinib-resistant KITT670I gatekeeper mutation in gastrointestinal stromal tumor. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 17699867	2007
Tumor mitotic rate, size, and location independently predict recurrence after resection of primary gastrointestinal stromal tumor (GIST). Cancer\| PubMed ID: 18076015	2008
Molecular characterization of pediatric gastrointestinal stromal tumors. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 18483389	2008
Novel V600E BRAF mutations in imatinib-naive and imatinib-resistant gastrointestinal stromal tumors. Genes, chromosomes & cancer\| PubMed ID: 18615679	2008
Changes in the structure and function of ICC networks in ICC hyperplasia and gastrointestinal stromal tumors. Gastroenterology\| PubMed ID: 19032955	2009
A KIT juxtamembrane PY567 -directed pathway provides nonredundant signals for erythroid progenitor cell development and stress erythropoiesis. Experimental hematology\| PubMed ID: 19100679	2009
Kit signaling via PI3K promotes ovarian follicle maturation but is dispensable for primordial follicle activation. Developmental biology\| PubMed ID: 19447101	2009
Mechanisms of sunitinib resistance in gastrointestinal stromal tumors harboring KITAY502-3ins mutation: an in vitro mutagenesis screen for drug resistance. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 19861442	2009
Kit ligand cytoplasmic domain is essential for basolateral sorting in vivo and has roles in spermatogenesis and hematopoiesis. Developmental biology\| PubMed ID: 19874813	2010
Imatinib upregulates compensatory integrin signaling in a mouse model of gastrointestinal stromal tumor and is more effective when combined with dasatinib. Molecular cancer research : MCR\| PubMed ID: 20736294	2010
Imatinib potentiates antitumor T cell responses in gastrointestinal stromal tumor through the inhibition of Ido. Nature medicine\| PubMed ID: 21873989	2011
CD133 and CD44 are universally overexpressed in GIST and do not represent cancer stem cell markers. Genes, chromosomes & cancer\| PubMed ID: 22076958	2012