invasive-hemodynamic-assessment-for-right-ventricular-system-hypoxia

Invasive Hemodynamic Assessment for the Right Ventricular System and Hypoxia-Induced Pulmonary Arterial Hypertension in Mice

Pulmonary arterial hypertension (PAH) is a chronic and severe cardiopulmonary disorder. Mice are a popular animal model used to mimic this disease. ...

Chinese Academy of Medical Sciences and Peking Union Medical College

The porcine mitral regurgitation (MR) model is a common cardiovascular animal model. Standardized manufacturing processes can improve the uniformity and success rate of the model, and systematic research can evaluate its potential use. In this study, 17 pigs were divided into an experimental group (n=11) and a control group (n=6). We used a homemade retractor to cut the mitral chordae via the left atrial appendage to establish a model of MR; the control group underwent a sham surgery. The model animals were followed for 30 months after the surgery. Enlargement and fibrosis of the left atrium were significant in the experimental group compared with those in the control group, and left atrial systolic function decreased significantly. In addition, model animals showed preserved left ventricular systolic function. There were no differences in left atrial potential or left ventricular myocardial fibrosis between the two groups. Atrial fibrillation susceptibility in the experimental group was higher than that in the control group. Our method enables the simple and effective production of a MR model with severe reflux that can be used for pathophysiological studies of MR, as well as for the development of preclinical surgical instruments and their evaluation. This model could also be used to study atrial fibrillation and myocardial fibrosis but is not suitable for studies of heart failure.

The characteristics of a porcine mitral regurgitation model.

The hybrid ablation via transdiaphragmatic approach (convergent procedure) is a newly emerging treatment for atrial fibrillation. However, the results reported by different centres are controversial. The purpose of this study is to investigate the efficacy and safety of the convergent procedure by performing a meta-analysis.

Efficacy and safety of the convergent atrial fibrillation procedure: a meta-analysis of observational studies.

Surgical intervention is the main treatment for a ruptured congenital sinus of Valsalva aneurysm (SVA). However, reports on the surgical experience are scarce. We retrospectively analysed the cases of our centre to summarize our 10-year experience.

Surgical repair of a ruptured congenital sinus of Valsalva aneurysm: 10-year experience with 286 cases.

The mechanism by which atrial fibrosis leads to the production and maintenance of atrial fibrillation (AF) is unclear. Myocardial biopsies, which have often been used in previous studies, are taken from a single site and do not always reflect the overall condition of atrial fibrosis.

Effects of atrial fibrosis induced by mitral regurgitation on atrial electrophysiology and susceptibility to atrial fibrillation in pigs.

A "boot camp" program is commonly adopted in surgical skills training. Due to a shortage of cardiac surgeons, establishment of a well-designed training curriculum for cardiac surgery residents is needed in developing countries.

Xiaokang Luo

Chinese Academy of Medical Sciences and Peking Union Medical College

Invasive Hemodynamic Assessment for the Right Ventricular System and Hypoxia-Induced Pulmonary Arterial Hypertension in Mice