Chi-Keung Cheng

Blood Cancer Cytogenetics and Genomics Laboratory,
Department of Anatomical and Cellular Pathology,
Prince of Wales Hospital,
Blood Cancer Cytogenetics and Genomics Laboratory, Department of Anatomical and Cellular Pathology, Prince of Wales Hospital

The Chinese University of Hong Kong

BIOGRAPHY

Dr. Cheng received his undergraduate degree (first class honors) and M.Phil. from the University of Hong Kong, and a Ph.D. from the University of British Columbia, Canada. He is currently in charge of the Molecular Hematology services in the Prince of Wales Hospital, Hong Kong. Dr. Cheng is also an Adjunct Associate Professor of the Department of Anatomical & Cellular Pathology, The Chinese University of Hong Kong. His main research focuses on the identification and molecular characterization of novel genetic/epigenetic aberrations in acute myeloid leukemia, a lethal blood cancer in adults and children. His work has been published in Blood, Haematologica and Molecular Cancer.

PUBLICATIONS

Transcriptional repression of the RUNX3/AML2 gene by the t(8;21) and inv(16) fusion proteins in acute myeloid leukemia.

Blood Oct, 2008 | Pubmed ID: 18663147

Secreted-frizzled related protein 1 is a transcriptional repression target of the t(8;21) fusion protein in acute myeloid leukemia.

Blood Dec, 2011 | Pubmed ID: 22031861

Platelet factor 4 induces cell apoptosis by inhibition of STAT3 via up-regulation of SOCS3 expression in multiple myeloma.

Haematologica Feb, 2013 | Pubmed ID: 22929979

A polymorphism in the 3'-untranslated region of the NPM1 gene causes illegitimate regulation by microRNA-337-5p and correlates with adverse outcome in acute myeloid leukemia.

Haematologica Jun, 2013 | Pubmed ID: 23065518

Draft genome sequence of Salmonella enterica serovar Typhimurium ST1660/06, a multidrug-resistant clinical strain isolated from a diarrheic patient.

Journal of bacteriology Nov, 2012 | Pubmed ID: 23105062

5'-Serial Analysis of Gene Expression studies reveal a transcriptomic switch during fruiting body development in Coprinopsis cinerea.

BMC genomics Mar, 2013 | Pubmed ID: 23514374

Minimal residual disease-based risk stratification in Chinese childhood acute lymphoblastic leukemia by flow cytometry and plasma DNA quantitative polymerase chain reaction.

PloS one , 2013 | Pubmed ID: 23936021

Genome Sequences of Salmonella enterica Serotype Typhimurium Blood Clinical Isolate ST4848/06 and Stool Isolate ST1489/06.

Genome announcements Oct, 2013 | Pubmed ID: 24136846

Congenital sideroblastic anaemia with a novel frameshift mutation in SLC25A38.

Journal of clinical pathology Mar, 2015 | Pubmed ID: 25512395

Next generation genome sequencing reveals phylogenetic clades with different level of virulence among Salmonella Typhimurium clinical human isolates in Hong Kong.

BMC genomics Sep, 2015 | Pubmed ID: 26370680

Helicase-like transcription factor is a RUNX1 target whose downregulation promotes genomic instability and correlates with complex cytogenetic features in acute myeloid leukemia.

Haematologica Apr, 2016 | Pubmed ID: 26802049

FNDC3B is another novel partner fused to RARA in the t(3;17)(q26;q21) variant of acute promyelocytic leukemia.

Blood 05, 2017 | Pubmed ID: 28314734

Distinctive regional-specific PROS1 mutation spectrum in Southern China.

Journal of thrombosis and thrombolysis Jul, 2018 | Pubmed ID: 29748776

Prevalence and Clinicopathologic Significance of BRAF V600E Mutation in Chinese Multiple Myeloma Patients.

Clinical lymphoma, myeloma & leukemia 07, 2018 | Pubmed ID: 29807803

RUNX1 upregulation via disruption of long-range transcriptional control by a novel t(5;21)(q13;q22) translocation in acute myeloid leukemia.

Molecular cancer 08, 2018 | Pubmed ID: 30157851

Discovery of microRNA-like RNAs during early fruiting body development in the model mushroom Coprinopsis cinerea.

PloS one , 2018 | Pubmed ID: 30231028

INSTITUTIONS

The Chinese University of Hong Kong

JOVE ARTICLES

Investigation of the Transcriptional Role of a RUNX1 Intronic Silencer by CRISPR/Cas9 Ribonucleoprotein in Acute Myeloid Leukemia Cells

Chi-Keung Cheng¹,

Terry H.Y. Wong¹,

Yuk-Lin Yung¹,

Nelson C.N. Chan¹,

Margaret H.L. Ng^1,2

¹Blood Cancer Cytogenetics and Genomics Laboratory, Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong,

²State Key Laboratory in Oncology in South China, The Chinese University of Hong Kong

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