National Center for Advancing Translational Sciences
Xinyan Huang is work at Dr. Antony Rodriguez lab as a postdoc from 2019.6 to 2021.5.
LSD1-mediated epigenetic modification is required for TAL1 function and hematopoiesis.
Proceedings of the National Academy of Sciences of the United States of America Jun, 2009 | Pubmed ID: 19497860
H4R3 methylation facilitates beta-globin transcription by regulating histone acetyltransferase binding and H3 acetylation.
Blood Mar, 2010 | Pubmed ID: 20068219
Novel patient cell-based HTS assay for identification of small molecules for a lysosomal storage disease.
PloS one , 2011 | Pubmed ID: 22216298
Probing the Donor and Acceptor Substrate Specificity of the γ-Glutamyl Transpeptidase.
Biochemistry Feb, 2012 | Pubmed ID: 22257032
Discovery of a novel noniminosugar acid α glucosidase chaperone series.
Journal of medicinal chemistry Sep, 2012 | Pubmed ID: 22834902
A high-throughput screening assay using Krabbe disease patient cells.
Analytical biochemistry Mar, 2013 | Pubmed ID: 23138179
Identification of small-molecule agonists of human relaxin family receptor 1 (RXFP1) by using a homogenous cell-based cAMP assay.
Journal of biomolecular screening Jul, 2013 | Pubmed ID: 23212924
Synthesis and biological evaluation of analogues of the kinase inhibitor nilotinib as Abl and Kit inhibitors.
Bioorganic & medicinal chemistry letters Feb, 2013 | Pubmed ID: 23273517
Inhibitors of the Yersinia protein tyrosine phosphatase through high throughput and virtual screening approaches.
Bioorganic & medicinal chemistry letters Feb, 2013 | Pubmed ID: 23294700
Identification and optimization of small-molecule agonists of the human relaxin hormone receptor RXFP1.
Nature communications , 2013 | Pubmed ID: 23764525
Disrupting malaria parasite AMA1-RON2 interaction with a small molecule prevents erythrocyte invasion.
Nature communications , 2013 | Pubmed ID: 23907321
Novel cell-based hepatitis C virus infection assay for quantitative high-throughput screening of anti-hepatitis C virus compounds.
Antimicrobial agents and chemotherapy , 2014 | Pubmed ID: 24277038
Structure-activity relationship studies and biological characterization of human NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase inhibitors.
Bioorganic & medicinal chemistry letters Jan, 2014 | Pubmed ID: 24360556
Discovery, optimization, and characterization of novel D2 dopamine receptor selective antagonists.
Journal of medicinal chemistry Apr, 2014 | Pubmed ID: 24666157
A high throughput screening assay system for the identification of small molecule inhibitors of gsp.
PloS one , 2014 | Pubmed ID: 24667240
Allosteric inhibitors of the Eya2 phosphatase are selective and inhibit Eya2-mediated cell migration.
The Journal of biological chemistry Jun, 2014 | Pubmed ID: 24755226
Discovery and characterization of a G protein-biased agonist that inhibits β-arrestin recruitment to the D2 dopamine receptor.
Molecular pharmacology Jul, 2014 | Pubmed ID: 24755247
Structural insight into exosite binding and discovery of novel exosite inhibitors of botulinum neurotoxin serotype A through in silico screening.
Journal of computer-aided molecular design Jul, 2014 | Pubmed ID: 24958623
Small Molecule, NSC95397, Inhibits the CtBP1-Protein Partner Interaction and CtBP1-Mediated Transcriptional Repression.
Journal of biomolecular screening Jun, 2015 | Pubmed ID: 25477201
Repurposing of the antihistamine chlorcyclizine and related compounds for treatment of hepatitis C virus infection.
Science translational medicine Apr, 2015 | Pubmed ID: 25855495
Discovery of NCT-501, a Potent and Selective Theophylline-Based Inhibitor of Aldehyde Dehydrogenase 1A1 (ALDH1A1).
Journal of medicinal chemistry Aug, 2015 | Pubmed ID: 26207746
High-Throughput Screening, Discovery, and Optimization To Develop a Benzofuran Class of Hepatitis C Virus Inhibitors.
ACS combinatorial science Oct, 2015 | Pubmed ID: 26332742
Activation of Relaxin Family Receptor 1 from Different Mammalian Species by Relaxin Peptide and Small-Molecule Agonist ML290.
Frontiers in endocrinology , 2015 | Pubmed ID: 26347712
Identification of novel anti-hepatitis C virus agents by a quantitative high throughput screen in a cell-based infection assay.
Antiviral research Dec, 2015 | Pubmed ID: 26515788
Discovery, Optimization, and Characterization of Novel Chlorcyclizine Derivatives for the Treatment of Hepatitis C Virus Infection.
Journal of medicinal chemistry Feb, 2016 | Pubmed ID: 26599718
Structural Insights into the Activation of Human Relaxin Family Peptide Receptor 1 by Small-Molecule Agonists.
Biochemistry Mar, 2016 | Pubmed ID: 26866459
CERAPP: Collaborative Estrogen Receptor Activity Prediction Project.
Environmental health perspectives 07, 2016 | Pubmed ID: 26908244
Targeting Estrogen Receptor Signaling with Fulvestrant Enhances Immune and Chemotherapy-Mediated Cytotoxicity of Human Lung Cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research Dec, 2016 | Pubmed ID: 27267852
Efficacy and Mechanism of Action of Low Dose Emetine against Human Cytomegalovirus.
PLoS pathogens 06, 2016 | Pubmed ID: 27336364
Cell-based high-throughput screening identifies galactocerebrosidase enhancers as potential small-molecule therapies for Krabbe's disease.
Journal of neuroscience research 11, 2016 | Pubmed ID: 27638606
High throughput cell-based assay for identification of glycolate oxidase inhibitors as a potential treatment for Primary Hyperoxaluria Type 1.
Scientific reports Sep, 2016 | Pubmed ID: 27670739
Synthetic non-peptide low molecular weight agonists of the relaxin receptor 1.
British journal of pharmacology 05, 2017 | Pubmed ID: 27771940
Development of an Aryloxazole Class of Hepatitis C Virus Inhibitors Targeting the Entry Stage of the Viral Replication Cycle.
Journal of medicinal chemistry 07, 2017 | Pubmed ID: 28636348
Mutation of Asn-475 in the Venezuelan Equine Encephalitis Virus nsP2 Cysteine Protease Leads to a Self-Inhibited State.
Biochemistry 11, 2017 | Pubmed ID: 29064679
Discovery of a Positive Allosteric Modulator of the Thyrotropin Receptor: Potentiation of Thyrotropin-Mediated Preosteoblast Differentiation In Vitro.
The Journal of pharmacology and experimental therapeutics 01, 2018 | Pubmed ID: 29089368
Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH).
Journal of medicinal chemistry 11, 2017 | Pubmed ID: 29120638
Insights into the Action of Inhibitor Enantiomers against Histone Lysine Demethylase 5A.
Journal of medicinal chemistry 04, 2018 | Pubmed ID: 29537847
In vivo CRISPR screening unveils histone demethylase UTX as an important epigenetic regulator in lung tumorigenesis.
Proceedings of the National Academy of Sciences of the United States of America 04, 2018 | Pubmed ID: 29632194
High-throughput screening identified selective inhibitors of exosome biogenesis and secretion: A drug repurposing strategy for advanced cancer.
Scientific reports 05, 2018 | Pubmed ID: 29802284
Emetine inhibits Zika and Ebola virus infections through two molecular mechanisms: inhibiting viral replication and decreasing viral entry.
Cell discovery , 2018 | Pubmed ID: 29872540
Optimization of the first small-molecule relaxin/insulin-like family peptide receptor (RXFP1) agonists: Activation results in an antifibrotic gene expression profile.
European journal of medicinal chemistry Aug, 2018 | Pubmed ID: 30006176
KDM5 histone demethylases repress immune response via suppression of STING.
PLoS biology 08, 2018 | Pubmed ID: 30080846
Discovery and lead identification of quinazoline-based BRD4 inhibitors.
Bioorganic & medicinal chemistry letters 11, 2018 | Pubmed ID: 30268702
Structure-Based Engineering of Irreversible Inhibitors against Histone Lysine Demethylase KDM5A.
Journal of medicinal chemistry 12, 2018 | Pubmed ID: 30392349
Identification of Chemotype Agonists for Human Resolvin D1 Receptor DRV1 with Pro-Resolving Functions.
Cell chemical biology 02, 2019 | Pubmed ID: 30554914
A large scale high-throughput screen identifies chemical inhibitors of phosphatidylinositol 4-kinase type II alpha.
Journal of lipid research Mar, 2019 | Pubmed ID: 30626625
Discovery of novel inhibitors of human galactokinase by virtual screening.
Journal of computer-aided molecular design Apr, 2019 | Pubmed ID: 30806949
Lead optimization and efficacy evaluation of quinazoline-based BET family inhibitors for potential treatment of cancer and inflammatory diseases.
Bioorganic & medicinal chemistry letters May, 2019 | Pubmed ID: 30905542
Therapeutic effects of a small molecule agonist of the relaxin receptor ML290 in liver fibrosis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology Nov, 2019 | Pubmed ID: 31419161
Implementation of biohybrid olfactory bulb on a high-density CMOS-chip to reveal large-scale spatiotemporal circuit information.
Biosensors & bioelectronics Feb, 2022 | Pubmed ID: 34852985
High-resolution CMOS-based biosensor for assessing hippocampal circuit dynamics in experience-dependent plasticity.
Biosensors & bioelectronics Oct, 2023 | Pubmed ID: 37379793
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