Ramon Arens

Department of Immunohematology and Blood Transfusion, Leiden University Medical Center

Affiliated withLeiden University Medical Center Leiden University Medical Center

Research Area

Immunology and Infection

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2019

Other Publications

Article	Year
Immunotherapy for persistent viral infections and associated disease. Trends in immunology\| PubMed ID: 21227751	2011
Differential B7-CD28 costimulatory requirements for stable and inflationary mouse cytomegalovirus-specific memory CD8 T cell populations. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 21357256	2011
Local activation of CD8 T cells and systemic tumor eradication without toxicity via slow release and local delivery of agonistic CD40 antibody. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 21389097	2011
Rational design of vaccines: learning from immune evasion mechanisms of persistent viruses and tumors. Advances in immunology\| PubMed ID: 22449784	2012
Polyfunctional CD4+ T cell responses to immunodominant epitopes correlate with disease activity of virulent Salmonella. PloS one\| PubMed ID: 22912884	2012
Vaccine-induced effector-memory CD8+ T cell responses predict therapeutic efficacy against tumors. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 22914049	2012
Predicting the efficacy of cancer vaccines by evaluating T-cell responses. Oncoimmunology\| PubMed ID: 23482345	2013
CD27-CD70 costimulation controls T cell immunity during acute and persistent cytomegalovirus infection. Journal of virology\| PubMed ID: 23576505	2013
Prospects of combinatorial synthetic peptide vaccine-based immunotherapy against cancer. Seminars in immunology\| PubMed ID: 23706598	2013
Controlled local delivery of CTLA-4 blocking antibody induces CD8+ T-cell-dependent tumor eradication and decreases risk of toxic side effects. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 23788581	2013
Lysine acetyltransferase PCAF is a key regulator of arteriogenesis. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 23788761	2013
The distinct role of T cell costimulation in antiviral immunity. Current opinion in virology\| PubMed ID: 23850168	2013
Nodular inflammatory foci are sites of T cell priming and control of murine cytomegalovirus infection in the neonatal lung. PLoS pathogens\| PubMed ID: 24348257	2013
Viral inoculum dose impacts memory T-cell inflation. European journal of immunology\| PubMed ID: 24356925	2014
Local immunomodulation for cancer therapy: Providing treatment where needed. Oncoimmunology\| PubMed ID: 24490127	2013
New advances in CMV and immunosenescence. Experimental gerontology\| PubMed ID: 24703889	2014
Enhanced cross-presentation and improved CD8+ T cell responses after mannosylation of synthetic long peptides in mice. PloS one\| PubMed ID: 25137039	2014
T Cell factor 1 represses CD8+ effector T cell formation and function. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 25355919	2014
The activation of the adaptive immune system: cross-talk between antigen-presenting cells, T cells and B cells. Immunology letters\| PubMed ID: 25455596	2014
Vaccine-induced tumor necrosis factor-producing T cells synergize with cisplatin to promote tumor cell death. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 25501579	2015
CD55 deposited on synovial collagen fibers protects from immune complex-mediated arthritis. Arthritis research & therapy\| PubMed ID: 25596646	2015
Enhanced CD8 T cell responses through GITR-mediated costimulation resolve chronic viral infection. PLoS pathogens\| PubMed ID: 25738498	2015
5(th) International Workshop on CMV and Immunosenescence - A shadow of cytomegalovirus infection on immunological memory. European journal of immunology\| PubMed ID: 25857239	2015
Therapeutic Peptide Vaccine-Induced CD8 T Cells Strongly Modulate Intratumoral Macrophages Required for Tumor Regression. Cancer immunology research\| PubMed ID: 25888578	2015
New approaches in vaccine-based immunotherapy for human papillomavirus-induced cancer. Current opinion in immunology\| PubMed ID: 26001120	2015
Cytomegalovirus- and Epstein-Barr Virus-Induced T-Cell Expansions in Young Children Do Not Impair Naive T-cell Populations or Vaccination Responses: The Generation R Study. The Journal of infectious diseases\| PubMed ID: 26142434	2016
Therapeutic cancer vaccines. The Journal of clinical investigation\| PubMed ID: 26214521	2015
The viral context instructs the redundancy of costimulatory pathways in driving CD8(+) T cell expansion. eLife\| PubMed ID: 26263500	2015
Abatacept decreases disease activity in a absence of CD4(+) T cells in a collagen-induced arthritis model. Arthritis research & therapy\| PubMed ID: 26290328	2015
The Quantity of Autocrine IL-2 Governs the Expansion Potential of CD8+ T Cells. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 26453748	2015
Murine cytomegalovirus (CMV) infection via the intranasal route offers a robust model of immunity upon mucosal CMV infection. The Journal of general virology\| PubMed ID: 26555192	2016
In Vivo Killing Capacity of Cytotoxic T Cells Is Limited and Involves Dynamic Interactions and T Cell Cooperativity. Immunity\| PubMed ID: 26872694	2016
Viral Persistence Induces Antibody Inflation without Altering Antibody Avidity. Journal of virology\| PubMed ID: 26889035	2016
Vaccines for established cancer: overcoming the challenges posed by immune evasion. Nature reviews. Cancer\| PubMed ID: 26965076	2016
Vaccination during myeloid cell depletion by cancer chemotherapy fosters robust T cell responses. Science translational medicine\| PubMed ID: 27075626	2016
Tumor Eradication by Cisplatin Is Sustained by CD80/86-Mediated Costimulation of CD8+ T Cells. Cancer research\| PubMed ID: 27569212	2016
The Breadth of Synthetic Long Peptide Vaccine-Induced CD8+ T Cell Responses Determines the Efficacy against Mouse Cytomegalovirus Infection. PLoS pathogens\| PubMed ID: 27637068	2016
Improving Adoptive T Cell Therapy: The Particular Role of T Cell Costimulation, Cytokines, and Post-Transfer Vaccination. Frontiers in immunology\| PubMed ID: 27656185	2016
The importance of correctly timing cancer immunotherapy. Expert opinion on biological therapy\| PubMed ID: 27802061	2017
Wnt Signaling as Master Regulator of T-Lymphocyte Responses: Implications for Transplant Therapy. Transplantation\| PubMed ID: 27861287	2016
Peptide Processing Is Critical for T-Cell Memory Inflation and May Be Optimized to Improve Immune Protection by CMV-Based Vaccine Vectors. PLoS pathogens\| PubMed ID: 27977791	2016
Enforced OX40 Stimulation Empowers Booster Vaccines to Induce Effective CD4 and CD8 T Cell Responses against Mouse Cytomegalovirus Infection. Frontiers in immunology\| PubMed ID: 28265272	2017
Inhibition of 14q32 microRNA miR-495 reduces lesion formation, intimal hyperplasia and plasma cholesterol levels in experimental restenosis. Atherosclerosis\| PubMed ID: 28445809	2017
CD4 T Cell and NK Cell Interplay Key to Regression of MHC Class I Tumors upon TLR7/8 Agonist Therapy. Cancer immunology research\| PubMed ID: 28637878	2017
CMV immune evasion and manipulation of the immune system with aging. GeroScience\| PubMed ID: 28647908	2017
Human plasmacytoid dendritic cells acquire phagocytic capacity by TLR9 ligation in the presence of soluble factors produced by renal epithelial cells. Kidney international\| PubMed ID: 29061332	2018
Exhaustion and Inflation at Antipodes of T Cell Responses to Chronic Virus Infection. Trends in microbiology\| PubMed ID: 29249600	2018
The Contribution of Cytomegalovirus Infection to Immune Senescence Is Set by the Infectious Dose. Frontiers in immunology\| PubMed ID: 29367854	2017
Features of Effective T Cell-Inducing Vaccines against Chronic Viral Infections. Frontiers in immunology\| PubMed ID: 29503649	2018
A flexible MHC class I multimer loading system for large-scale detection of antigen-specific T cells. The Journal of experimental medicine\| PubMed ID: 29666167	2018
Impact of congenital cytomegalovirus infection on transcriptomes from archived dried blood spots in relation to long-term clinical outcome. PloS one\| PubMed ID: 30024899	2018
FcγRI expression on macrophages is required for antibody-mediated tumor protection by cytomegalovirus-based vaccines. Oncotarget\| PubMed ID: 30034625	2018
OX40 Stimulation Enhances Protective Immune Responses Induced After Vaccination With Attenuated Malaria Parasites. Frontiers in cellular and infection microbiology\| PubMed ID: 30073152	2018
Cytomegalovirus infection and progressive differentiation of effector-memory T cells. F1000Research\| PubMed ID: 30345004	2018
: A workflow for visual and quantitative analysis of flow and mass cytometry data to discover immune signatures and correlations. Computational and structural biotechnology journal\| PubMed ID: 30450167	2018
. Science immunology\| PubMed ID: 30552101	2018
Demarcated thresholds of tumor-specific CD8 T cells elicited by MCMV-based vaccine vectors provide robust correlates of protection. Journal for immunotherapy of cancer\| PubMed ID: 30704520	2019
T cell co-stimulation and co-inhibition in cardiovascular disease: a double-edged sword. Nature reviews. Cardiology\| PubMed ID: 30770894	2019
Peripheral and systemic antigens elicit an expandable pool of resident memory CD8 T cells in the bone marrow. European journal of immunology\| PubMed ID: 30891737	2019
The hallmarks of CMV-specific CD8 T-cell differentiation. Medical microbiology and immunology\| PubMed ID: 30989333	2019
CD8+ T Cells Protect During Vein Graft Disease Development. Frontiers in cardiovascular medicine\| PubMed ID: 31263704	2019
PD-L1 blockade engages tumor-infiltrating lymphocytes to co-express targetable activating and inhibitory receptors. Journal for immunotherapy of cancer\| PubMed ID: 31412943	2019
A poly-neoantigen DNA vaccine synergizes with PD-1 blockade to induce T cell-mediated tumor control. Oncoimmunology\| PubMed ID: 31646082	2019