Patrick Vanscheeuwijck

PMI R&D, Philip Morris Products S.A.

Affiliated withPhilip Morris Products S.A.

Research Area

Engineering

Biography

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JoVE Journal Publications

Article Total : 1	Year
Publication title	2022

Other Publications

Article	Year
Cigarette smoke induces molecular responses in respiratory tissues of ApoE(-/-) mice that are progressively deactivated upon cessation. Toxicology\| PubMed ID: 24096154	2013
A 28-day rat inhalation study with an integrated molecular toxicology endpoint demonstrates reduced exposure effects for a prototypic modified risk tobacco product compared with conventional... Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association\| PubMed ID: 24632068	2014
A 7-month cigarette smoke inhalation study in C57BL/6 mice demonstrates reduced lung inflammation and emphysema following smoking cessation or aerosol exposure from a prototypic modified ris... Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association\| PubMed ID: 25843363	2015
Systems toxicology approaches enable mechanistic comparison of spontaneous and cigarette smoke-related lung tumor development in the A/J mouse model. Interdisciplinary toxicology\| PubMed ID: 26109882	2014
An 8-Month Systems Toxicology Inhalation/Cessation Study in Apoe-/- Mice to Investigate Cardiovascular and Respiratory Exposure Effects of a Candidate Modified Risk Tobacco Product, THS 2.2,... Toxicological sciences : an official journal of the Society of Toxicology\| PubMed ID: 26609137	2016
Comprehensive systems biology analysis of a 7-month cigarette smoke inhalation study in C57BL/6 mice. Scientific data\| PubMed ID: 26731301	2016
Evaluation of the Tobacco Heating System 2.2. Part 1: Description of the system and the scientific assessment program. Regulatory toxicology and pharmacology : RTP\| PubMed ID: 27450400	2016
Evaluation of the Tobacco Heating System 2.2. Part 2: Chemical composition, genotoxicity, cytotoxicity, and physical properties of the aerosol. Regulatory toxicology and pharmacology : RTP\| PubMed ID: 27720919	2016
Evaluation of the Tobacco Heating System 2.2. Part 4: 90-day OECD 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects compared with cigarette smo... Regulatory toxicology and pharmacology : RTP\| PubMed ID: 27793746	2016
Evaluation of the Tobacco Heating System 2.2. Part 7: Systems toxicological assessment of a mentholated version revealed reduced cellular and molecular exposure effects compared with menthol... Regulatory toxicology and pharmacology : RTP\| PubMed ID: 27818347	2016
Evaluation of the Tobacco Heating System 2.2. Part 6: 90-day OECD 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects of a mentholated version co... Regulatory toxicology and pharmacology : RTP\| PubMed ID: 27818348	2016
Toxicity of the main electronic cigarette components, propylene glycol, glycerin, and nicotine, in Sprague-Dawley rats in a 90-day OECD inhalation study complemented by molecular endpoints. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association\| PubMed ID: 28882640	2017
Supporting evidence-based analysis for modified risk tobacco products through a toxicology data-sharing infrastructure. F1000Research\| PubMed ID: 29123642	2017
A 90-day OECD TG 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects of the aerosol from the carbon heated tobacco product version 1.2 (CHTP1.2) ... Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association\| PubMed ID: 29545142	2018
A 90-day OECD TG 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects of the aerosol from the carbon heated tobacco product version 1.2 (CHTP1.2) ... Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association\| PubMed ID: 29654848	2018
A six-month systems toxicology inhalation/cessation study in ApoE mice to investigate cardiovascular and respiratory exposure effects of modified risk tobacco products, CHTP 1.2 and THS 2.2,... Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association\| PubMed ID: 30763686	2019
Assessing the lung cancer risk reduction potential of candidate modified risk tobacco products. Internal and emergency medicine\| PubMed ID: 30767158	2019
Biological changes in C57BL/6 mice following 3 weeks of inhalation exposure to cigarette smoke or e-vapor aerosols. Inhalation toxicology\| PubMed ID: 30849254	2018
Mode-of-action analysis of the effects induced by nicotine in the in vitro micronucleus assay. Environmental and molecular mutagenesis\| PubMed ID: 31294873	2019
Respirable aerosol exposures of nicotine dry powder formulations to , , and pre-clinical models demonstrate consistency of pharmacokinetic profiles. Inhalation toxicology\| PubMed ID: 31496314	2019
Lysosomotropic-related limitations of the BALB/c 3T3 cell-based neutral red uptake assay and an alternative testing approach for assessing e-liquid cytotoxicity. Toxicology in vitro : an international journal published in association with BIBRA\| PubMed ID: 31518669	2019
Structural, functional, and molecular impact on the cardiovascular system in ApoE mice exposed to aerosol from candidate modified risk tobacco products, Carbon Heated Tobacco Product 1.2 and... Chemico-biological interactions\| PubMed ID: 31705857	2020
Development of an integrated assay in human TK6 cells to permit comprehensive genotoxicity analysis in vitro. Mutation research. Genetic toxicology and environmental mutagenesis\| PubMed ID: 32087850	2020
Evaluation of toxicity of aerosols from flavored e-liquids in Sprague-Dawley rats in a 90-day OECD inhalation study, complemented by transcriptomics analysis. Archives of toxicology\| PubMed ID: 32367274	2020
Multi-omics systems toxicology study of mouse lung assessing the effects of aerosols from two heat-not-burn tobacco products and cigarette smoke. Computational and structural biotechnology journal\| PubMed ID: 32419906	2020
Reduced Chronic Toxicity and Carcinogenicity in A/J Mice in Response to Life-Time Exposure to Aerosol From a Heated Tobacco Product Compared With Cigarette Smoke. Toxicological sciences : an official journal of the Society of Toxicology\| PubMed ID: 32780830	2020
Respiratory Effects of Exposure to Aerosol From the Candidate Modified-Risk Tobacco Product THS 2.2 in an 18-Month Systems Toxicology Study With A/J Mice. Toxicological sciences : an official journal of the Society of Toxicology\| PubMed ID: 32780831	2020
Profiling of a Natural Alkaloid, Anatabine, in Rodents: Pharmacokinetics and Anti-Inflammatory Efficacy. Journal of natural products\| PubMed ID: 33706515	2021
Impact of whole-body versus nose-only inhalation exposure systems on systemic, respiratory, and cardiovascular endpoints in a 2-month cigarette smoke exposure study in the ApoE mouse model. Journal of applied toxicology : JAT\| PubMed ID: 33825214	2021
A 6-month inhalation toxicology study in Apoe mice demonstrates substantially lower effects of e-vapor aerosol compared with cigarette smoke in the respiratory tract. Archives of toxicology\| PubMed ID: 33963423	2021
Impact of 6-Month Exposure to Aerosols From Potential Modified Risk Tobacco Products Relative to Cigarette Smoke on the Rodent Gastrointestinal Tract. Frontiers in microbiology\| PubMed ID: 34276574	2021
Discriminating Spontaneous From Cigarette Smoke and THS 2.2 Aerosol Exposure-Related Proliferative Lung Lesions in A/J Mice by Using Gene Expression and Mutation Spectrum Data. Frontiers in toxicology\| PubMed ID: 35295134	2021