Stuart J. Forbes

Unbiased screening of polymer libraries to define novel substrates for functional hepatocytes with inducible drug metabolism.

Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair.

Progenitor cell characterization and location in the developing human liver.

Stem cell therapy for chronic liver disease--choosing the right tools for the job.

Regulation of alternative macrophage activation by galectin-3.

The inhibitory role of stromal cell mesenchyme on human embryonic stem cell hepatocyte differentiation is overcome by Wnt3a treatment.

Highly efficient differentiation of hESCs to functional hepatic endoderm requires ActivinA and Wnt3a signaling.

The isolation and in vitro expansion of hepatic Sca-1 progenitor cells.

Side population cells in developing human liver are primarily haematopoietic progenitor cells.

A fat chance for hepatocyte transplantation?

Generation of functional human hepatic endoderm from human induced pluripotent stem cells.

Practical barriers to delivering autologous bone marrow stem cell therapy as an adjunct to liver resection.

Liver development, regeneration, and carcinogenesis.

Portal venous endothelium in developing human liver contains haematopoietic and epithelial progenitor cells.

Characterisation of a stereotypical cellular and extracellular adult liver progenitor cell niche in rodents and diseased human liver.

Prospects for stem cell transplantation in the treatment of hepatic disease.

Persistence of functional hepatocyte-like cells in immune-compromised mice.

Macrophage therapy for murine liver fibrosis recruits host effector cells improving fibrosis, regeneration, and function.

Matrix stiffness modulates proliferation, chemotherapeutic response, and dormancy in hepatocellular carcinoma cells.

Liver fibrogenic cells.

Ly6Chi monocytes direct alternatively activated profibrotic macrophage regulation of lung fibrosis.

Regulation of transforming growth factor-β1-driven lung fibrosis by galectin-3.

Elastin accumulation is regulated at the level of degradation by macrophage metalloelastase (MMP-12) during experimental liver fibrosis.

Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease.

Liver sinusoidal endothelial cells in disease--and for therapy?

Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis.

Bone marrow injection stimulates hepatic ductular reactions in the absence of injury via macrophage-mediated TWEAK signaling.

Suppression of Epithelial to Mesenchymal Transitioning (EMT) Enhances Ex Vivo Reprogramming of Human Exocrine Pancreatic Tissue towards Functional Insulin Producing β-Like Cells.

Differentiation of progenitors in the liver: a matter of local choice.

Relaxin modulates human and rat hepatic myofibroblast function and ameliorates portal hypertension in vivo.

Cell lineage tracing reveals a biliary origin of intrahepatic cholangiocarcinoma.

Links between hepatic fibrosis, ductular reaction, and progenitor cell expansion.

CD133+ cancer stem-like cells in small cell lung cancer are highly tumorigenic and chemoresistant but sensitive to a novel neuropeptide antagonist.

Proteinase activated receptor 1 mediated fibrosis in a mouse model of liver injury: a role for bone marrow derived macrophages.

Polysialic acid/neural cell adhesion molecule modulates the formation of ductular reactions in liver injury.

Markedly Increased High-Mobility Group Box 1 Protein in a Patient with Small-for-Size Syndrome.

Galectin-3 regulates hepatic progenitor cell expansion during liver injury.

Preparing the ground for tissue regeneration: from mechanism to therapy.

Alternatively activated (M2) macrophages promote tumour growth and invasiveness in hepatocellular carcinoma.

Polymer Supported Directed Differentiation Reveals a Unique Gene Signature Predicting Stable Hepatocyte Performance.

Organoid cultures boost human liver cell expansion.

Hepatic progenitor cells of biliary origin with liver repopulation capacity.

Polyurethane: Stable Cell Phenotype Requires Plasticity: Polymer Supported Directed Differentiation Reveals a Unique Gene Signature Predicting Stable Hepatocyte Performance (Adv. Healthcare Mater. 12/2015).

Phenotypic and functional characterization of macrophages with therapeutic potential generated from human cirrhotic monocytes in a cohort study.

CSF1 Restores Innate Immunity After Liver Injury in Mice and Serum Levels Indicate Outcomes of Patients With Acute Liver Failure.

Two Fresh Streams to Fill the Liver's Hepatocyte Pool.

Krüppel-Like Factor 4 Overexpression Initiates a Mesenchymal-to-Epithelial Transition and Redifferentiation of Human Pancreatic Cells following Expansion in Long Term Adherent Culture.

Recombinant Laminins Drive the Differentiation and Self-Organization of hESC-Derived Hepatocytes.

Vasopressin Regulates Extracellular Vesicle Uptake by Kidney Collecting Duct Cells.

Reducing Hepatocyte Injury and Necrosis in Response to Paracetamol Using Noncoding RNAs.

The RSPO-LGR4/5-ZNRF3/RNF43 module controls liver zonation and size.

Expert consensus document: Cholangiocarcinoma: current knowledge and future perspectives consensus statement from the European Network for the Study of Cholangiocarcinoma (ENS-CCA).

Corrigendum to "Alternatively activated (M2) macrophages promote tumour growth and invasiveness in hepatocellular carcinoma" [J Hepatol 2015;62:607-616].

Liver regeneration - mechanisms and models to clinical application.

Interleukin-13 Activates Distinct Cellular Pathways Leading to Ductular Reaction, Steatosis, and Fibrosis.

Wnt signalling modulates transcribed-ultraconserved regions in hepatobiliary cancers.

Notch3 drives development and progression of cholangiocarcinoma.

Advances in cholangiocarcinoma research: report from the third Cholangiocarcinoma Foundation Annual Conference.

Functionalized superparamagnetic iron oxide nanoparticles provide highly efficient iron-labeling in macrophages for magnetic resonance-based detection in vivo.

Milk Fat Globule-EGF Factor 8 for Liver Fibrosis Therapy: Creaming Off the Beneficial Effects of Mesenchymal Stromal Cells.

Development, functional characterization and validation of methodology for GMP-compliant manufacture of phagocytic macrophages: A novel cellular therapeutic for liver cirrhosis.

Cholangiocytes act as facultative liver stem cells during impaired hepatocyte regeneration.

11Beta-hydroxysteroid dehydrogenase-1 deficiency or inhibition enhances hepatic myofibroblast activation in murine liver fibrosis.

The STAT3-IL-10-IL-6 Pathway Is a Novel Regulator of Macrophage Efferocytosis and Phenotypic Conversion in Sterile Liver Injury.

GADD45β Loss Ablates Innate Immunosuppression in Cancer.

Raman spectroscopy and regenerative medicine: a review.

Studies of macrophage therapy for cirrhosis - From mice to men.

Paracrine cellular senescence exacerbates biliary injury and impairs regeneration.

TGFβ inhibition restores a regenerative response in acute liver injury by suppressing paracrine senescence.

3D human liver tissue from pluripotent stem cells displays stable phenotype in vitro and supports compromised liver function in vivo.

Hepatocyte-Specific β-Catenin Deletion During Severe Liver Injury Provokes Cholangiocytes to Differentiate Into Hepatocytes.

Telomerase Activity Links to Regenerative Capacity of Hepatocytes.

Cellular Plasticity in Liver Regeneration: Spotlight on Cholangiocytes.

Mesenchymal Stem Cells and Induced Bone Marrow-Derived Macrophages Synergistically Improve Liver Fibrosis in Mice.

An Orally Active Galectin-3 Antagonist Inhibits Lung Adenocarcinoma Growth and Augments Response to PD-L1 Blockade.

Quantifying changes in innate immune function following liver transplantation for chronic liver disease.

Beneficial Noncancerous Mutations in Liver Disease.

Macrophages as a Cell-Based Therapy for Liver Disease.

Peribiliary Gland Niche Participates in Biliary Tree Regeneration in Mouse and in Human Primary Sclerosing Cholangitis.

Safety profile of autologous macrophage therapy for liver cirrhosis.

Epigenetic remodelling licences adult cholangiocytes for organoid formation and liver regeneration.

Modulation of biliary cancer chemo-resistance through microRNA-mediated rewiring of the expansion of CD133+ cells.

Expansion, in vivo-ex vivo cycling, and genetic manipulation of primary human hepatocytes.

Regional differences in human biliary tissues and corresponding in vitro derived organoids.

Absolute measurement of the tissue origins of cell-free DNA in the healthy state and following paracetamol overdose.

TFEB regulates murine liver cell fate during development and regeneration.