synthesis-aptamer-pei-g-peg-modified-gold-nanoparticles-loaded-with

Synthesis of Aptamer-PEI-g-PEG Modified Gold Nanoparticles Loaded with Doxorubicin for Targeted Drug Delivery

Due to drug resistance and toxicity in healthy cells, use of doxorubicin (DOX) has been limited in clinical cancer therapy. This protocol describes the ...

Xinyang Normal University

A practical and efficient method for selective intramolecular radical trifluoromethylacylation and -arylation of alkenes with inexpensive CFSONa and KSO in aqueous media has been developed, respectively, affording the highly chemoselective synthesis of CF-functionalized chroman-4-ones and chromanes in satisfactory yields. Control experiments and DFT calculations indicate that the CFSONa/KSO system is capable of trifluoromethylating the substrate of alkenes without a transition metal catalyst and the oxidation of CFSONa to ·CF by KSO is involved in the rate-determining step.

KSO-Mediated Selective Trifluoromethylacylation and Trifluoromethylarylation of Alkenes under Transition-Metal-Free Conditions: Synthetic Scope and Mechanistic Studies.

The first experimental evidence for the palladium-catalyzed secondary bond activation of allylic alcohols in a Tsuji-Trost reaction was provided by NMR methods, such as variable-temperature H NMR, diffusion-ordered spectroscopy (DOSY), Job's method, H NMR titration, and nuclear Overhauser enhancement spectroscopy (NOESY). The experimental results revealed that the substrate self-assisted activation of allylic alcohols is probably performed via a 1:1 binding six-membered-ring complex, which are formed by the formation of the secondary bonds, the hydrogen bond and P···O noncovalent bond between allylic alcohol and phosphonium ylide.

Substrate Self-Assisted Secondary Bond Activation of Allylic Alcohol in a Tsuji-Trost Reaction Revealed by NMR Methods.

Tremendous energy consumption is required for traditional artificial N fixation, leading to additional environmental pollution. Recently, new Li-N batteries have inextricably integrated energy storage with N fixation. In this work, graphene is introduced into Li-N batteries and enhances the cycling stability. However, the instability and hygroscopicity of the discharge product Li N lead to a rechargeable but irreversible system. Moreover, strong nonpolar N≡N covalent triple bonds with high ionization energies also cause low efficiency and irreversibility of Li-N batteries. In contrast, the modification with in situ generated Li N and LiOH restrained the loss and volume change of Li metal anodes during stripping and plating, thereby promoting the rechargeability of the Li-N batteries. The mechanistic study here will assist in the design of more stable Li-N batteries and create more versatile methods for N fixation.

Li-N Batteries: A Reversible Energy Storage System?

A substrate self-assisted activation of allylic alcohols by tautomerizable heteroarenes via hydrogen bonding was disclosed by various NMR techniques, including variable-temperature H NMR, Job plot, and H NMR titration. Guided by these finding, a much milder allylic substitution of tautomerizable heteroarenes with allylic alcohols was developed, affording the target products in high yields.

Article	Year
KSO-Mediated Selective Trifluoromethylacylation and Trifluoromethylarylation of Alkenes under Transition-Metal-Free Conditions: Synthetic Scope and Mechanistic Studies. Organic letters\| PubMed ID: 30289263	2018
Substrate Self-Assisted Secondary Bond Activation of Allylic Alcohol in a Tsuji-Trost Reaction Revealed by NMR Methods. The Journal of organic chemistry\| PubMed ID: 31091095	2019
Li-N Batteries: A Reversible Energy Storage System? Angewandte Chemie (International ed. in English)\| PubMed ID: 31595612	2019
Insights into Substrate Self-Assisted Activation of Allylic Alcohols Guiding to Mild Allylic Substitution of Tautomerizable Heteroarenes. The Journal of organic chemistry\| PubMed ID: 32151136	2020

Lingyun Zheng

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