Christian Doppler Laboratory for Allergy Diagnosis and Therapy
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Genetic engineering of allergens: future therapeutic products.
International archives of allergy and immunology , | Pubmed ID: 12119498
Gene gun bombardment with gold particles displays a particular Th2-promoting signal that over-rules the Th1-inducing effect of immunostimulatory CpG motifs in DNA vaccines.
Vaccine , | Pubmed ID: 12163266
Art v 1, the major allergen of mugwort pollen, is a modular glycoprotein with a defensin-like and a hydroxyproline-rich domain.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology Jan, 2003 | Pubmed ID: 12475905
Molecular and immunological characterization of profilin from mugwort pollen.
Biological chemistry , | Pubmed ID: 12530543
IgE-mediated immediate-type hypersensitivity to the pyrazolone drug propyphenazone.
The Journal of allergy and clinical immunology Apr, 2003 | Pubmed ID: 12704373
Prevention of allergen-specific IgE production and suppression of an established Th2-type response by immunization with DNA encoding hypoallergenic allergen derivatives of Bet v 1, the major birch-pollen allergen.
European journal of immunology , | Pubmed ID: 12778485
TH1-promoting DNA immunization against allergens modulates the ratio of IgG1/IgG2a but does not affect the anaphylactic potential of IgG1 antibodies: no evidence for the synthesis of nonanaphylactic IgG1.
The Journal of allergy and clinical immunology , | Pubmed ID: 13679818
Lab scale and medium scale production of recombinant allergens in Escherichia coli.
Methods (San Diego, Calif.) , | Pubmed ID: 14962755
Over-expression and production of plant allergens by molecular farming strategies.
Methods (San Diego, Calif.) Mar, 2004 | Pubmed ID: 14962757
Customized antigens for desensitizing allergic patients.
Advances in immunology , | Pubmed ID: 15246251
Biology of weed pollen allergens.
Current allergy and asthma reports Sep, 2004 | Pubmed ID: 15283880
The spectrum of allergens in ragweed and mugwort pollen.
International archives of allergy and immunology , | Pubmed ID: 16254437
Is genetic vaccination against allergy possible?
International archives of allergy and immunology , | Pubmed ID: 16534215
Modified recombinant allergens for safer immunotherapy.
Inflammation & allergy drug targets , | Pubmed ID: 16613559
Calcium-binding proteins and their role in allergic diseases.
Immunology and allergy clinics of North America , | Pubmed ID: 17276877
Specific immunotherapy in pollen allergy.
Current opinion in molecular therapeutics , | Pubmed ID: 17458170
Allergy multivaccines created by DNA shuffling of tree pollen allergens.
The Journal of allergy and clinical immunology , | Pubmed ID: 17624416
Immune recognition of novel isoforms and domains of the mugwort pollen major allergen Art v 1.
Molecular immunology , | Pubmed ID: 19054564
The alpha and beta subchain of Amb a 1, the major ragweed-pollen allergen show divergent reactivity at the IgE and T-cell level.
Molecular immunology , | Pubmed ID: 19269031
Role of the polypeptide backbone and post-translational modifications in cross-reactivity of Art v 1, the major mugwort pollen allergen.
Biological chemistry May-Jun, 2009 | Pubmed ID: 19361284
Isoform identification and characterization of Art v 3, the lipid-transfer protein of mugwort pollen.
Molecular immunology Jun, 2009 | Pubmed ID: 19406480
Development of recombinant allergens for diagnosis and therapy.
Frontiers in bioscience (Elite edition) , 2009 | Pubmed ID: 19482627
Immunize and disappear-safety-optimized mRNA vaccination with a panel of 29 allergens.
The Journal of allergy and clinical immunology , | Pubmed ID: 19665781
Characterization of plant food allergens: an overview on physicochemical and immunological techniques.
Molecular nutrition & food research Jan, 2010 | Pubmed ID: 19960453
Antigen aggregation decides the fate of the allergic immune response.
Journal of immunology (Baltimore, Md. : 1950) Jan, 2010 | Pubmed ID: 19995902
Targeting the cysteine-stabilized fold of Art v 1 for immunotherapy of Artemisia pollen allergy.
Molecular immunology Mar, 2010 | Pubmed ID: 20022115
The influence of recombinant production on the immunologic behavior of birch pollen isoallergens.
PloS one , 2009 | Pubmed ID: 20041109
Naturally processed T cell-activating peptides of the major birch pollen allergen.
The Journal of allergy and clinical immunology , | Pubmed ID: 20132976
Panallergens and their impact on the allergic patient.
Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology , | Pubmed ID: 20298513
Designing hypoallergenic derivatives for allergy treatment by means of in silico mutation and screening.
The Journal of allergy and clinical immunology , | Pubmed ID: 20371399
Molecular metamorphosis in polcalcin allergens by EF-hand rearrangements and domain swapping.
The FEBS journal , | Pubmed ID: 20553495
A new allergen from ragweed (Ambrosia artemisiifolia) with homology to art v 1 from mugwort.
The Journal of biological chemistry Aug, 2010 | Pubmed ID: 20576600
The role of lipid transfer proteins in allergic diseases.
Current allergy and asthma reports , | Pubmed ID: 20582490
Prophylactic mRNA vaccination against allergy.
Current opinion in allergy and clinical immunology , | Pubmed ID: 20856111
Diclofenac hypersensitivity: antibody responses to the parent drug and relevant metabolites.
PloS one , 2010 | Pubmed ID: 21060839
Production of recombinant allergens in plants.
Phytochemistry reviews : proceedings of the Phytochemical Society of Europe Oct, 2008 | Pubmed ID: 21258627
Assessing protein immunogenicity with a dendritic cell line-derived endolysosomal degradome.
PloS one , | Pubmed ID: 21359181
Proteomic profiling of birch (Betula verrucosa) pollen extracts from different origins.
Proteomics Apr, 2011 | Pubmed ID: 21360672
Reshaping the Bet v 1 fold modulates T(H) polarization.
The Journal of allergy and clinical immunology Jun, 2011 | Pubmed ID: 21420160
Molecular characterization of Api g 2, a novel allergenic member of the lipid-transfer protein 1 family from celery stalks.
Molecular nutrition & food research Apr, 2011 | Pubmed ID: 21462324
Is aboriginal food less allergenic? Comparing IgE-reactivity of eggs from modern and ancient chicken breeds in a cohort of allergic children.
PloS one , | Pubmed ID: 21552565
Ozone affects pollen viability and NAD(P)H oxidase release from Ambrosia artemisiifolia pollen.
Environmental pollution (Barking, Essex : 1987) , | Pubmed ID: 21605929
Sensitization prevalence, antibody cross-reactivity and immunogenic peptide profile of Api g 2, the non-specific lipid transfer protein 1 of celery.
PloS one , | Pubmed ID: 21897872
Expression of the major mugwort pollen allergen Art v 1 in tobacco plants and cell cultures: problems and perspectives for allergen production in plants.
Plant cell reports , | Pubmed ID: 22159963
Specific allergen concentration of WHO and FDA reference preparations measured using a multiple allergen standard.
The Journal of allergy and clinical immunology , | Pubmed ID: 22277198
Nitration of the pollen allergen bet v 1.0101 enhances the presentation of bet v 1-derived peptides by HLA-DR on human dendritic cells.
PloS one , | Pubmed ID: 22348091
Response to Detection and analysis of unusual features in the structural model and structure-factor data of a birch pollen allergen.
Acta crystallographica. Section F, Structural biology and crystallization communications , | Pubmed ID: 22505401
Heat-induced structural changes affect OVA-antigen processing and reduce allergic response in mouse model of food allergy.
PloS one , | Pubmed ID: 22629361
Crystallographically mapped ligand binding differs in high and low IgE binding isoforms of birch pollen allergen bet v 1.
Journal of molecular biology , | Pubmed ID: 22634284
Glutaraldehyde-Modified Recombinant Fel d 1: A Hypoallergen With Negligible Biological Activity But Retained Immunogenicity.
The World Allergy Organization journal , | Pubmed ID: 23268458
Previously undescribed grass pollen antigens are the major inducers of T helper 2 cytokine-producing T cells in allergic individuals.
Proceedings of the National Academy of Sciences of the United States of America , | Pubmed ID: 23401558
Molecular and immunological characterization of ragweed (Ambrosia artemisiifolia L.) pollen after exposure of the plants to elevated ozone over a whole growing season.
PloS one , | Pubmed ID: 23637846
Allergens of weed pollen: an overview on recombinant and natural molecules.
Methods (San Diego, Calif.) , | Pubmed ID: 23806644
Allergenic relevance of nonspecific lipid transfer proteins 2: Identification and characterization of Api g 6 from celery tuber as representative of a novel IgE-binding protein family.
Molecular nutrition & food research , | Pubmed ID: 23913675
The fold variant BM4 is beneficial in a therapeutic Bet v 1 mouse model.
BioMed research international , | Pubmed ID: 24175303
Proteomic and immunochemical characterization of glutathione transferase as a new allergen of the nematode Ascaris lumbricoides.
PloS one , | Pubmed ID: 24223794
Stabilization of the dimeric birch pollen allergen Bet v 1 impacts its immunological properties.
The Journal of biological chemistry , | Pubmed ID: 24253036
Recombinant allergens for pollen immunotherapy.
Immunotherapy , | Pubmed ID: 24283843
Plantago lanceolata: an important trigger of summer pollinosis with limited IgE cross-reactivity.
The Journal of allergy and clinical immunology , | Pubmed ID: 24698322
Molecular approach to allergy diagnosis and therapy.
Yonsei medical journal , | Pubmed ID: 24954310
The impact of nitration on the structure and immunogenicity of the major birch pollen allergen Bet v 1.0101.
PloS one , | Pubmed ID: 25126882
Glutathione-S-transferase: a minor allergen in birch pollen due to limited release from hydrated pollen.
PloS one , | Pubmed ID: 25275548
Ligand binding modulates the structural dynamics and compactness of the major birch pollen allergen.
Biophysical journal , | Pubmed ID: 25517162
Correlation of sensitizing capacity and T-cell recognition within the Bet v 1 family.
The Journal of allergy and clinical immunology , | Pubmed ID: 25670010
Pectate lyase pollen allergens: sensitization profiles and cross-reactivity pattern.
PloS one , | Pubmed ID: 25978036
Fold stability during endolysosomal acidification is a key factor for allergenicity and immunogenicity of the major birch pollen allergen.
The Journal of allergy and clinical immunology , | Pubmed ID: 26559323
Elevated Toll-Like Receptor-Induced CXCL8 Secretion in Human Blood Basophils from Allergic Donors Is Independent of Toll-Like Receptor Expression Levels.
PloS one , | Pubmed ID: 26870962
AllergenOnline: A peer-reviewed, curated allergen database to assess novel food proteins for potential cross-reactivity.
Molecular nutrition & food research , | Pubmed ID: 26887584
Advances in patent applications related to allergen immunotherapy.
Expert opinion on therapeutic patents , | Pubmed ID: 27011299
How relevant is panallergen sensitization in the development of allergies?
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology , | Pubmed ID: 27129102
Regulatory T Cell Specificity Directs Tolerance versus Allergy against Aeroantigens in Humans.
Cell , | Pubmed ID: 27773482
Tackling Bet v 1 and associated food allergies with a single hybrid protein.
The Journal of allergy and clinical immunology , | Pubmed ID: 27939703
Crystal structure of Pla l 1 reveals both structural similarity and allergenic divergence within the Ole e 1-like protein family.
The Journal of allergy and clinical immunology , | Pubmed ID: 27965108
T Cell Epitope-Containing Domains of Ragweed Amb a 1 and Mugwort Art v 6 Modulate Immunologic Responses in Humans and Mice.
PloS one , | Pubmed ID: 28081194
Fusion proteins of flagellin and the major birch pollen allergen Bet v 1 show enhanced immunogenicity, reduced allergenicity, and intrinsic adjuvanticity.
The Journal of allergy and clinical immunology , | Pubmed ID: 28456624
Allergens of Blomia tropicalis: An Overview of Recombinant Molecules.
International archives of allergy and immunology , | Pubmed ID: 28456805
Expression and Characterization of Functional Recombinant Bet v 1.0101 in the Chloroplast of Chlamydomonas reinhardtii.
International archives of allergy and immunology , | Pubmed ID: 28494467
Identification of Proteases and Protease Inhibitors in Allergenic and Non-Allergenic Pollen.
International journal of molecular sciences , | Pubmed ID: 28587253
Multi-Approach Analysis for the Identification of Proteases within Birch Pollen.
International journal of molecular sciences , | Pubmed ID: 28677627
Proteomic profiling of the weed feverfew, a neglected pollen allergen source.
Scientific reports , | Pubmed ID: 28729676
NMR resonance assignments of a hypoallergenic isoform of the major birch pollen allergen Bet v 1.
Biomolecular NMR assignments , | Pubmed ID: 28808910
Conjugation of wildtype and hypoallergenic mugwort allergen Art v 1 to flagellin induces IL-10-DC and suppresses allergen-specific TH2-responses in vivo.
Scientific reports , | Pubmed ID: 28924222
Two Distinct Conformations in Bet v 2 Determine Its Proteolytic Resistance to Cathepsin S.
International journal of molecular sciences , | Pubmed ID: 29035299
Endolysosomal protease susceptibility of Amb a 1 as a determinant of allergenicity.
The Journal of allergy and clinical immunology , | Pubmed ID: 29157946
Author Correction: Conjugation of wildtype and hypoallergenic mugwort allergen Art v 1 to flagellin induces IL-10-DC and suppresses allergen-specific TH2-responses in vivo.
Scientific reports , | Pubmed ID: 29410477
Context matters: T2 polarization resulting from pollen composition and not from protein-intrinsic allergenicity.
The Journal of allergy and clinical immunology , | Pubmed ID: 29782896
Harmonization of the Genetic Code Effectively Enhances the Recombinant Production of the Major Birch Pollen Allergen Bet v 1.
International archives of allergy and immunology , 2018 | Pubmed ID: 29940558
Structural basis for cross-reactivity and conformation fluctuation of the major beech pollen allergen Fag s 1.
Scientific reports , | Pubmed ID: 30002383
The somatic proteins of Toxocara canis larvae and excretory-secretory products revealed by proteomics.
Veterinary parasitology , | Pubmed ID: 30056980
Artemisia pollen allergy in China: Component-resolved diagnosis reveals allergic asthma patients have significant multiple allergen sensitization.
Allergy , | Pubmed ID: 30155917
Does clinical outcome of birch pollen immunotherapy relate to induction of blocking antibodies preventing IgE from allergen binding? A pilot study monitoring responses during first year of AIT.
Clinical and translational allergy , | Pubmed ID: 30338052
Localization of Four Allergens in Artemisia Pollen by Immunofluorescent Antibodies.
International archives of allergy and immunology , | Pubmed ID: 30970365
Legends of Allergy and Immunology: From a curious mind to a world class scientist-A brief biography of Professor T.P. King.
Allergy , | Pubmed ID: 31125433
Rational Design, Structure-Activity Relationship, and Immunogenicity of Hypoallergenic Pru p 3 Variants.
Molecular nutrition & food research , | Pubmed ID: 31207117
Multiple roles of Bet v 1 ligands in allergen stabilization and modulation of endosomal protease activity.
Allergy , | Pubmed ID: 31230350
Similar Allergenicity to Different Species Is a Consequence of Highly Cross-Reactive Art v 1-Like Molecules.
Medicina (Kaunas, Lithuania) , | Pubmed ID: 31434264
Proteomic Analysis Reveals Allergen Variability among Breeds of the Dust Mite Blomia tropicalis.
International archives of allergy and immunology , | Pubmed ID: 31563904
TGFβ1 mimetic peptide modulates immune response to grass pollen allergens in mice.
Allergy , | Pubmed ID: 31750952
N-terminal peptide deletion influences immunological and structural features of Blo t 5.
Allergy , | Pubmed ID: 31916257
Defining biomarkers to predict symptoms in subjects with and without allergy under natural pollen exposure.
The Journal of allergy and clinical immunology , | Pubmed ID: 32272131
A hybrid of two major Blomia tropicalis allergens as an allergy vaccine candidate.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology , | Pubmed ID: 32314444
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