Lars Hviid

Centre for Medical Parasitology, University of Copenhagen

Affiliated withUniversity of Copenhagen Rigshospitalet

Research Area

Immunology and Infection

Biography

JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2020

Other Publications

Article	Year
Intermittent preventive sulfadoxine-pyrimethamine treatment of primigravidae reduces levels of plasma immunoglobulin G, which protects against pregnancy-associated Plasmodium falciparum mala... Infection and immunity\| PubMed ID: 15321995	2004
Looking for Needles in the Plasmodial Haystack. mSphere\| PubMed ID: 30918061	2019
Levels of antibody to conserved parts of Plasmodium falciparum merozoite surface protein 1 in Ghanaian children are not associated with protection from clinical malaria. Infection and immunity\| PubMed ID: 10225865	1999
A longitudinal study of human antibody responses to Plasmodium falciparum rhoptry-associated protein 1 in a region of seasonal and unstable malaria transmission. Infection and immunity\| PubMed ID: 10338508	1999
Nine-year longitudinal study of antibodies to variant antigens on the surface of Plasmodium falciparum-infected erythrocytes. Infection and immunity\| PubMed ID: 10417178	1999
Differential patterns of human immunoglobulin G subclass responses to distinct regions of a single protein, the merozoite surface protein 1 of Plasmodium falciparum. Infection and immunity\| PubMed ID: 11160024	2001
What is the cause of lymphopenia in malaria? Infection and immunity\| PubMed ID: 11203040	2000
Perturbation and proinflammatory type activation of V delta 1(+) gamma delta T cells in African children with Plasmodium falciparum malaria. Infection and immunity\| PubMed ID: 11292740	2001
Antibodies to variant antigens on the surfaces of infected erythrocytes are associated with protection from malaria in Ghanaian children. Infection and immunity\| PubMed ID: 11349035	2001
Selection of glutamate-rich protein long synthetic peptides for vaccine development: antigenicity and relationship with clinical protection and immunogenicity. Infection and immunity\| PubMed ID: 11500389	2001
Insecticide-treated bed nets reduce plasma antibody levels and limit the repertoire of antibodies to Plasmodium falciparum variant surface antigens. Clinical and diagnostic laboratory immunology\| PubMed ID: 11687480	2001
Plasmodium falciparum variant surface antigen expression varies between isolates causing severe and nonsevere malaria and is modified by acquired immunity. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 11907103	2002
Increased levels of soluble CD30 in plasma of patients with Plasmodium falciparum malaria. Clinical and diagnostic laboratory immunology\| PubMed ID: 11986285	2002
Malaria-induced acquisition of antibodies to Plasmodium falciparum variant surface antigens. Infection and immunity\| PubMed ID: 12010988	2002
A sub-family of common and highly conserved Plasmodium falciparum var genes. Molecular and biochemical parasitology\| PubMed ID: 12076777	2002
In vivo switching between variant surface antigens in human Plasmodium falciparum infection. The Journal of infectious diseases\| PubMed ID: 12195363	2002
Novel Plasmodium falciparum malaria vaccines: evidence-based searching for variant surface antigens as candidates for vaccination against pregnancy-associated malaria. Immunology letters\| PubMed ID: 12270550	2002
Expression of variant surface antigens by Plasmodium falciparum parasites in the peripheral blood of clinically immune pregnant women indicates ongoing placental infection. Infection and immunity\| PubMed ID: 12595482	2003
Specificity and cross-reactivity of Plasmodium falciparum variant surface antigen-specific antibody responses. Infection and immunity\| PubMed ID: 12654861	2003
Acute P. falciparum malaria induces a loss of CD28- T IFN-gamma producing cells. Parasite immunology\| PubMed ID: 12694605	2002
Lack of gender-specific antibody recognition of products from domains of a var gene implicated in pregnancy-associated Plasmodium falciparum malaria. Infection and immunity\| PubMed ID: 12819117	2003
Selective upregulation of a single distinctly structured var gene in chondroitin sulphate A-adhering Plasmodium falciparum involved in pregnancy-associated malaria. Molecular microbiology\| PubMed ID: 12823820	2003
Variant surface antigen-specific IgG and protection against clinical consequences of pregnancy-associated Plasmodium falciparum malaria. Lancet (London, England)\| PubMed ID: 14751701	2004
Plasmodium falciparum associated with severe childhood malaria preferentially expresses PfEMP1 encoded by group A var genes. The Journal of experimental medicine\| PubMed ID: 15123742	2004
Geographical and temporal conservation of antibody recognition of Plasmodium falciparum variant surface antigens. Infection and immunity\| PubMed ID: 15155661	2004
Analysis of IgG with specificity for variant surface antigens expressed by placental Plasmodium falciparum isolates. Malaria journal\| PubMed ID: 15242514	2004
Antibodies to the N-terminal block 2 of Plasmodium falciparum merozoite surface protein 1 are associated with protection against clinical malaria. Infection and immunity\| PubMed ID: 15501780	2004
Evidence for the involvement of VAR2CSA in pregnancy-associated malaria. The Journal of experimental medicine\| PubMed ID: 15520249	2004
Rapid acquisition of isolate-specific antibodies to chondroitin sulfate A-adherent plasmodium falciparum isolates in Ghanaian primigravidae. Infection and immunity\| PubMed ID: 15845489	2005
Expression of Plasmodium falciparum erythrocyte membrane protein 1 in experimentally infected humans. Malaria journal\| PubMed ID: 15857512	2005
Effects of pregnancy and intensity of Plasmodium falciparum transmission on immunoglobulin G subclass responses to variant surface antigens. Infection and immunity\| PubMed ID: 15972500	2005
Differential induction of immunoglobulin G to Plasmodium falciparum variant surface antigens during the transmission season in Daraweesh, Sudan. The Journal of infectious diseases\| PubMed ID: 15995968	2005
Naturally acquired immunity to Plasmodium falciparum malaria in Africa. Acta tropica\| PubMed ID: 16018958	2005
Levels of plasma immunoglobulin G with specificity against the cysteine-rich interdomain regions of a semiconserved Plasmodium falciparum erythrocyte membrane protein 1, VAR4, predict protec... Infection and immunity\| PubMed ID: 16622225	2006
Plasmodium falciparum parasites expressing pregnancy-specific variant surface antigens adhere strongly to the choriocarcinoma cell line BeWo. Infection and immunity\| PubMed ID: 16622246	2006
Baculovirus-expressed constructs induce immunoglobulin G that recognizes VAR2CSA on Plasmodium falciparum-infected erythrocytes. Infection and immunity\| PubMed ID: 16790811	2006
Epitope mapping and topographic analysis of VAR2CSA DBL3X involved in P. falciparum placental sequestration. PLoS pathogens\| PubMed ID: 17112315	2006
Human pregnancy-associated malaria-specific B cells target polymorphic, conformational epitopes in VAR2CSA. Molecular microbiology\| PubMed ID: 17176260	2007
Immunoglobulin G antibody reactivity to a group A Plasmodium falciparum erythrocyte membrane protein 1 and protection from P. falciparum malaria. Infection and immunity\| PubMed ID: 17283085	2007
Development of vaccines against Plasmodium falciparum malaria: taking lessons from naturally acquired protective immunity. Microbes and infection\| PubMed ID: 17398137	2007
Selective activation of TCR-gammadelta+ cells in endemic Burkitt's lymphoma. Malaria journal\| PubMed ID: 17521425	2007
Adhesion specificities of Plasmodium falciparum-infected erythrocytes involved in the pathogenesis of pregnancy-associated malaria. The American journal of pathology\| PubMed ID: 17525250	2007
Changes in var gene mRNA levels during erythrocytic development in two phenotypically distinct Plasmodium falciparum parasites. Malaria journal\| PubMed ID: 17565661	2007
Differences in human antibody reactivity to Plasmodium falciparum variant surface antigens are dependent on age and malaria transmission intensity in northeastern Tanzania. Infection and immunity\| PubMed ID: 18250179	2008
Malaria vaccines: immunity, models and monoclonal antibodies. Trends in parasitology\| PubMed ID: 18675589	2008
VAR2CSA expression on the surface of placenta-derived Plasmodium falciparum-infected erythrocytes. The Journal of infectious diseases\| PubMed ID: 18700835	2008
CD36 selection of 3D7 Plasmodium falciparum associated with severe childhood malaria results in reduced VAR4 expression. Malaria journal\| PubMed ID: 18844973	2008
Variant-specific immunity to Plasmodium berghei in pregnant mice. Infection and immunity\| PubMed ID: 19237516	2009
Unraveling the impact of malaria exposure before birth. PLoS medicine\| PubMed ID: 19636354	2009
The role of Plasmodium falciparum variant surface antigens in protective immunity and vaccine development. Human vaccines\| PubMed ID: 19823032	2010
Immune selection and within-host competition can structure the repertoire of variant surface antigens in Plasmodium falciparum--a mathematical model. PloS one\| PubMed ID: 20339540	2010
The kinetics of antibody binding to Plasmodium falciparum VAR2CSA PfEMP1 antigen and modelling of PfEMP1 antigen packing on the membrane knobs. Malaria journal\| PubMed ID: 20403153	2010
Of mice and women: rodent models of placental malaria. Trends in parasitology\| PubMed ID: 20605743	2010
Hierarchical, domain type-specific acquisition of antibodies to Plasmodium falciparum erythrocyte membrane protein 1 in Tanzanian children. Infection and immunity\| PubMed ID: 20823214	2010
Chondroitin sulfate A-adhering Plasmodium falciparum-infected erythrocytes express functionally important antibody epitopes shared by multiple variants. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 21078904	2010
Evasion of immunity to Plasmodium falciparum malaria by IgM masking of protective IgG epitopes in infected erythrocyte surface-exposed PfEMP1. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21746929	2011
The case for PfEMP1-based vaccines to protect pregnant women against Plasmodium falciparum malaria. Expert review of vaccines\| PubMed ID: 21988306	2011
Aligned hemozoin crystals in curved clusters in malarial red blood cells revealed by nanoprobe X-ray Fe fluorescence and diffraction. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22733729	2012
Insights into deregulated TNF and IL-10 production in malaria: implications for understanding severe malarial anaemia. Malaria journal\| PubMed ID: 22853732	2012
The density of knobs on Plasmodium falciparum-infected erythrocytes depends on developmental age and varies among isolates. PloS one\| PubMed ID: 23029166	2012
A novel domain cassette identifies Plasmodium falciparum PfEMP1 proteins binding ICAM-1 and is a target of cross-reactive, adhesion-inhibitory antibodies. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 23209327	2013
Plasmodium falciparum expressing domain cassette 5 type PfEMP1 (DC5-PfEMP1) bind PECAM1. PloS one\| PubMed ID: 23874884	2013
Transfected HEK293 cells expressing functional recombinant intercellular adhesion molecule 1 (ICAM-1)--a receptor associated with severe Plasmodium falciparum malaria. PloS one\| PubMed ID: 23936131	2013
Cytokine response to pregnancy-associated recrudescence of Plasmodium berghei infection in mice with pre-existing immunity to malaria. Malaria journal\| PubMed ID: 24180253	2013
Modeling malaria infection and immunity against variant surface antigens in Príncipe Island, West Africa. PloS one\| PubMed ID: 24520349	2014
B-cell responses to pregnancy-restricted and -unrestricted Plasmodium falciparum erythrocyte membrane protein 1 antigens in Ghanaian women naturally exposed to malaria parasites. Infection and immunity\| PubMed ID: 24566620	2014
Kinetics of B cell responses to Plasmodium falciparum erythrocyte membrane protein 1 in Ghanaian women naturally exposed to malaria parasites. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 24760153	2014
Inhibition of Plasmepsin V activity demonstrates its essential role in protein export, PfEMP1 display, and survival of malaria parasites. PLoS biology\| PubMed ID: 24983235	2014
Investigating the function of Fc-specific binding of IgM to Plasmodium falciparum erythrocyte membrane protein 1 mediating erythrocyte rosetting. Cellular microbiology\| PubMed ID: 25482886	2015
Trying to remember: immunological B cell memory to malaria. Trends in parasitology\| PubMed ID: 25596801	2015
PfEMP1 - A Parasite Protein Family of Key Importance in Plasmodium falciparum Malaria Immunity and Pathogenesis. Advances in parasitology\| PubMed ID: 25911365	2015
Rifins, rosetting, and red blood cells. Trends in parasitology\| PubMed ID: 25959958	2015
α2-Macroglobulin Can Crosslink Multiple Plasmodium falciparum Erythrocyte Membrane Protein 1 (PfEMP1) Molecules and May Facilitate Adhesion of Parasitized Erythrocytes. PLoS pathogens\| PubMed ID: 26134405	2015
Multiple Plasmodium falciparum Erythrocyte Membrane Protein 1 Variants per Genome Can Bind IgM via Its Fc Fragment Fcμ. Infection and immunity\| PubMed ID: 26216422	2015
Plasmodium falciparum-infected erythrocyte knob density is linked to the PfEMP1 variant expressed. mBio\| PubMed ID: 26443460	2015
Immunoglobulin M: Restrainer of Inflammation and Mediator of Immune Evasion by Plasmodium falciparum Malaria. Trends in parasitology\| PubMed ID: 26597020	2016
[A worm in the toilet]. Ugeskrift for laeger\| PubMed ID: 27063009	2016
Structure-Guided Identification of a Family of Dual Receptor-Binding PfEMP1 that Is Associated with Cerebral Malaria. Cell host & microbe\| PubMed ID: 28279348	2017
Increased Plasmodium chabaudi malaria mortality in mice with nutritional iron deficiency can be reduced by short-term adjunctive iron supplementation. Malaria journal\| PubMed ID: 29338760	2018
Natural and Vaccine-Induced Acquisition of Cross-Reactive IgG-Inhibiting ICAM-1-Specific Binding of a Plasmodium falciparum PfEMP1 Subtype Associated Specifically with Cerebral Malaria. Infection and immunity\| PubMed ID: 29426042	2018
Etiology of Placental Plasmodium falciparum Malaria in African Women. The Journal of infectious diseases\| PubMed ID: 29579263	2018
IgG Responses to the Plasmodium falciparum Antigen VAR2CSA in Colombia Are Restricted to Pregnancy and Are Not Induced by Exposure to Plasmodium vivax. Infection and immunity\| PubMed ID: 29784859	2018
Kinetics of antibody responses to PfRH5-complex antigens in Ghanaian children with Plasmodium falciparum malaria. PloS one\| PubMed ID: 29883485	2018
A vaccine targeted specifically to prevent cerebral malaria - is there hope? Expert review of vaccines\| PubMed ID: 29898617	2018
Blood outgrowth endothelial cells (BOECs) as a novel tool for studying adhesion of Plasmodium falciparum-infected erythrocytes. PloS one\| PubMed ID: 30300360	2018
Malaria causes long-term effects on markers of iron status in children: a critical assessment of existing clinical and epidemiological tools. Malaria journal\| PubMed ID: 30537973	2018
Evasion of Classical Complement Pathway Activation on -Infected Erythrocytes Opsonized by PfEMP1-Specific IgG. Frontiers in immunology\| PubMed ID: 30666256	2018
Human Vδ1 T Cells in the Immune Response to Infection. Frontiers in immunology\| PubMed ID: 30837999	2019
Functional Antibodies against Placental Malaria Parasites Are Variant Dependent and Differ by Geographic Region. Infection and immunity\| PubMed ID: 30988054	2019
Comprehensive analysis of Fc-mediated IgM binding to the Plasmodium falciparum erythrocyte membrane protein 1 family in three parasite clones. Scientific reports\| PubMed ID: 30988351	2019
Acquisition of IgG to ICAM-1-Binding DBLβ Domains in the Plasmodium falciparum Erythrocyte Membrane Protein 1 Antigen Family Varies between Groups A, B, and C. Infection and immunity\| PubMed ID: 31308082	2019
Cerebral Plasmodium falciparum malaria: The role of PfEMP1 in its pathogenesis and immunity, and PfEMP1-based vaccines to prevent it. Immunological reviews\| PubMed ID: 31562653	2020
Reliable cell and tissue morphology-based diagnosis of endemic Burkitt lymphoma in resource-constrained settings in Ghana. BMC cancer\| PubMed ID: 31888714	2019
Endemic Burkitt lymphoma - an aggressive childhood cancer linked to Plasmodium falciparum exposure, but not to exposure to other malaria parasites. APMIS : acta pathologica, microbiologica, et immunologica Scandinavica\| PubMed ID: 32133709	2020
Precipitated Malaria: It Never Rains but It Pours. Trends in parasitology\| PubMed ID: 32507384	2020
In vitro selection for adhesion of Plasmodium falciparum-infected erythrocytes to ABO antigens does not affect PfEMP1 and RIFIN expression. Scientific reports\| PubMed ID: 32732983	2020