Department of Medicine
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Identification of mitogen-activated protein kinase kinase as a chemoresistant pathway in MCF-7 cells by using gene expression microarray.
Surgery Aug, 2002 | Pubmed ID: 12219026
Sensitization of apoptotically-resistant breast carcinoma cells to TNF and TRAIL by inhibition of p38 mitogen-activated protein kinase signaling.
International journal of oncology Jun, 2004 | Pubmed ID: 15138590
PKC-mediated survival signaling in breast carcinoma cells: a role for MEK1-AP1 signaling.
International journal of oncology Mar, 2005 | Pubmed ID: 15703835
p38 mitogen-activated protein kinase stimulates estrogen-mediated transcription and proliferation through the phosphorylation and potentiation of the p160 coactivator glucocorticoid receptor-interacting protein 1.
Molecular endocrinology (Baltimore, Md.) May, 2006 | Pubmed ID: 16410316
Drugs designed to inhibit human p38 mitogen-activated protein kinase activation treat Toxoplasma gondii and Encephalitozoon cuniculi infection.
Antimicrobial agents and chemotherapy Dec, 2007 | Pubmed ID: 17923491
Combination of methylselenocysteine with tamoxifen inhibits MCF-7 breast cancer xenografts in nude mice through elevated apoptosis and reduced angiogenesis.
Breast cancer research and treatment Nov, 2009 | Pubmed ID: 18855134
Proteomic analysis of tumor necrosis factor-alpha resistant human breast cancer cells reveals a MEK5/Erk5-mediated epithelial-mesenchymal transition phenotype.
Breast cancer research : BCR , 2008 | Pubmed ID: 19087274
Molecular effects of soy phytoalexin glyceollins in human prostate cancer cells LNCaP.
Molecular carcinogenesis Sep, 2009 | Pubmed ID: 19263441
Sphingolipids as determinants of apoptosis and chemoresistance in the MCF-7 cell model system.
Experimental biology and medicine (Maywood, N.J.) Nov, 2009 | Pubmed ID: 19546354
Design, synthesis, and biological activity of a family of novel ceramide analogues in chemoresistant breast cancer cells.
Journal of medicinal chemistry Sep, 2009 | Pubmed ID: 19694470
Systems genetics analyses predict a transcription role for P2P-R: molecular confirmation that P2P-R is a transcriptional co-repressor.
BMC systems biology Feb, 2010 | Pubmed ID: 20184719
Regulation of ERalpha-mediated transcription of Bcl-2 by PI3K-AKT crosstalk: implications for breast cancer cell survival.
International journal of oncology Sep, 2010 | Pubmed ID: 20664923
Effects of 7-O substitutions on estrogenic and anti-estrogenic activities of daidzein analogues in MCF-7 breast cancer cells.
Journal of medicinal chemistry Aug, 2010 | Pubmed ID: 20669983
Antiestrogenic effects of the novel sphingosine kinase-2 inhibitor ABC294640.
Endocrinology Nov, 2010 | Pubmed ID: 20861237
Inhibition of breast cancer cell invasion by melatonin is mediated through regulation of the p38 mitogen-activated protein kinase signaling pathway.
Breast cancer research : BCR , 2010 | Pubmed ID: 21167057
Targeting NFĸB mediated breast cancer chemoresistance through selective inhibition of sphingosine kinase-2.
Cancer biology & therapy Apr, 2011 | Pubmed ID: 21307639
Pharmacological inhibition of sphingosine kinase isoforms alters estrogen receptor signaling in human breast cancer.
Journal of molecular endocrinology Jun, 2011 | Pubmed ID: 21321095
Sorafenib enhances pemetrexed cytotoxicity through an autophagy-dependent mechanism in cancer cells.
Cancer research Jul, 2011 | Pubmed ID: 21622715
MEK5/ERK5 pathway: the first fifteen years.
Biochimica et biophysica acta Jan, 2012 | Pubmed ID: 22020294
Glyceollin-elicited soy protein consumption induces distinct transcriptional effects as compared to standard soy protein.
Journal of agricultural and food chemistry Jan, 2012 | Pubmed ID: 22126086
Environmental signaling and reproduction: a comparative biological and chemical perspective.
Molecular and cellular endocrinology May, 2012 | Pubmed ID: 22178089
Proteomic analysis of acquired tamoxifen resistance in MCF-7 cells reveals expression signatures associated with enhanced migration.
Breast cancer research : BCR Mar, 2012 | Pubmed ID: 22417809
Dual inhibition of sphingosine kinase isoforms ablates TNF-induced drug resistance.
Oncology reports Jun, 2012 | Pubmed ID: 22469881
The microRNA expression associated with morphogenesis of breast cancer cells in three-dimensional organotypic culture.
Oncology reports Jul, 2012 | Pubmed ID: 22576799
The organochlorine o,p'-DDT plays a role in coactivator-mediated MAPK crosstalk in MCF-7 breast cancer cells.
Environmental health perspectives Sep, 2012 | Pubmed ID: 22609851
Inhibition of p38-MAPK alters SRC coactivation and estrogen receptor phosphorylation.
Cancer biology & therapy Sep, 2012 | Pubmed ID: 22825349
Altered death receptor signaling promotes epithelial-to-mesenchymal transition and acquired chemoresistance.
Scientific reports , 2012 | Pubmed ID: 22844580
Sphingosine kinase isoforms as a therapeutic target in endocrine therapy resistant luminal and basal-A breast cancer.
Experimental biology and medicine (Maywood, N.J.) Jul, 2012 | Pubmed ID: 22859737
In vitro and in vivo evaluation of novel anticancer agents in triple negative breast cancer models.
Journal of health care for the poor and underserved Feb, 2013 | Pubmed ID: 23395947
Inhibition of p38 mitogen-activated protein kinase alters microRNA expression and reverses epithelial-to-mesenchymal transition.
International journal of oncology Apr, 2013 | Pubmed ID: 23403951
Discovery of a Series of Thiazole Derivatives as Novel Inhibitors of Metastatic Cancer Cell Migration and Invasion.
ACS medicinal chemistry letters Feb, 2013 | Pubmed ID: 23526571
MEK5/ERK5 signaling suppresses estrogen receptor expression and promotes hormone-independent tumorigenesis.
PloS one , 2013 | Pubmed ID: 23950888
Obesity associated alterations in the biology of adipose stem cells mediate enhanced tumorigenesis by estrogen dependent pathways.
Breast cancer research : BCR , 2013 | Pubmed ID: 24176089
Design, synthesis, and osteogenic activity of daidzein analogs on human mesenchymal stem cells.
ACS medicinal chemistry letters Feb, 2014 | Pubmed ID: 24900787
Inhibition of sphingosine kinase-2 ablates androgen resistant prostate cancer proliferation and survival.
Pharmacological reports : PR Feb, 2014 | Pubmed ID: 24905325
Effects of the endocrine-disrupting chemical DDT on self-renewal and differentiation of human mesenchymal stem cells.
Environmental health perspectives Jan, 2015 | Pubmed ID: 25014179
Bisphenol A enhances adipogenic differentiation of human adipose stromal/stem cells.
Journal of molecular endocrinology Dec, 2014 | Pubmed ID: 25143472
Novel daidzein analogs enhance osteogenic activity of bone marrow-derived mesenchymal stem cells and adipose-derived stromal/stem cells through estrogen receptor dependent and independent mechanisms.
Stem cell research & therapy Aug, 2014 | Pubmed ID: 25168698
Concise review: The obesity cancer paradigm: exploration of the interactions and crosstalk with adipose stem cells.
Stem cells (Dayton, Ohio) Feb, 2015 | Pubmed ID: 25267443
microRNA regulation of mammalian target of rapamycin expression and activity controls estrogen receptor function and RAD001 sensitivity.
Molecular cancer Oct, 2014 | Pubmed ID: 25283550
Elevated expression of long intergenic non-coding RNA HOTAIR in a basal-like variant of MCF-7 breast cancer cells.
Molecular carcinogenesis Dec, 2015 | Pubmed ID: 25328122
Glyceollin, a novel regulator of mTOR/p70S6 in estrogen receptor positive breast cancer.
The Journal of steroid biochemistry and molecular biology Jun, 2015 | Pubmed ID: 25771071
Leptin produced by obese adipose stromal/stem cells enhances proliferation and metastasis of estrogen receptor positive breast cancers.
Breast cancer research : BCR Aug, 2015 | Pubmed ID: 26286584
A novel gastrointestinal microbiome modulator from soy pods reduces absorption of dietary fat in mice.
Obesity (Silver Spring, Md.) Jan, 2016 | Pubmed ID: 26584538
Glyceollin I Reverses Epithelial to Mesenchymal Transition in Letrozole Resistant Breast Cancer through ZEB1.
International journal of environmental research and public health Dec, 2015 | Pubmed ID: 26703648
Induction of HOXA9 expression in three-dimensional organotypic culture of the Claudin-low breast cancer cells.
Oncotarget Aug, 2016 | Pubmed ID: 27409175
Endocrine disruptors and the tumor microenvironment: A new paradigm in breast cancer biology.
Molecular and cellular endocrinology Dec, 2017 | Pubmed ID: 28012841
The Effects of Endocrine Disruptors on Adipogenesis and Osteogenesis in Mesenchymal Stem Cells: A Review.
Frontiers in endocrinology , 2016 | Pubmed ID: 28119665
Oncogenic signaling of MEK5-ERK5.
Cancer letters 04, 2017 | Pubmed ID: 28153789
Osteoinductive effects of glyceollins on adult mesenchymal stromal/stem cells from adipose tissue and bone marrow.
Phytomedicine : international journal of phytotherapy and phytopharmacology Apr, 2017 | Pubmed ID: 28314478
Glycinol enhances osteogenic differentiation and attenuates the effects of age on mesenchymal stem cells.
Regenerative medicine 07, 2017 | Pubmed ID: 28718749
Dual Src Kinase/Pretubulin Inhibitor KX-01, Sensitizes ERα-negative Breast Cancers to Tamoxifen through ERα Reexpression.
Molecular cancer research : MCR 11, 2017 | Pubmed ID: 28751463
Targeting CXCL12/CXCR4 Axis in Tumor Immunotherapy.
Current medicinal chemistry , 2019 | Pubmed ID: 28875842
A novel patient-derived xenograft model for claudin-low triple-negative breast cancer.
Breast cancer research and treatment Jun, 2018 | Pubmed ID: 29392581
ZB716, a steroidal selective estrogen receptor degrader (SERD), is orally efficacious in blocking tumor growth in mouse xenograft models.
Oncotarget Jan, 2018 | Pubmed ID: 29467940
Obesity Enhances the Conversion of Adipose-Derived Stromal/Stem Cells into Carcinoma-Associated Fibroblast Leading to Cancer Cell Proliferation and Progression to an Invasive Phenotype.
Stem cells international , 2017 | Pubmed ID: 29527228
Argonaute 2 Expression Correlates with a Luminal B Breast Cancer Subtype and Induces Estrogen Receptor Alpha Isoform Variation.
Non-coding RNA Sep, 2016 | Pubmed ID: 29657266
Panobinostat suppresses the mesenchymal phenotype in a novel claudin-low triple negative patient-derived breast cancer model.
Oncoscience Mar, 2018 | Pubmed ID: 29854878
Notch Signaling Regulates Mitochondrial Metabolism and NF-κB Activity in Triple-Negative Breast Cancer Cells via IKKα-Dependent Non-canonical Pathways.
Frontiers in oncology , 2018 | Pubmed ID: 30564555
Drug resistance profiling of a new triple negative breast cancer patient-derived xenograft model.
BMC cancer Mar, 2019 | Pubmed ID: 30845999
Obesity-Altered Adipose Stem Cells Promote ER⁺ Breast Cancer Metastasis through Estrogen Independent Pathways.
International journal of molecular sciences Mar, 2019 | Pubmed ID: 30897853
Pharmacological, Mechanistic, and Pharmacokinetic Assessment of Novel Melatonin-Tamoxifen Drug Conjugates as Breast Cancer Drugs.
Molecular pharmacology 08, 2019 | Pubmed ID: 31221824
Pharmacological inhibition of the MEK5/ERK5 and PI3K/Akt signaling pathways synergistically reduces viability in triple-negative breast cancer.
Journal of cellular biochemistry 02, 2020 | Pubmed ID: 31464004
Targeting TRAF3IP2, Compared to Rab27, is More Effective in Suppressing the Development and Metastasis of Breast Cancer.
Scientific reports 06, 2020 | Pubmed ID: 32483202
A novel screening approach comparing kinase activity of small molecule inhibitors with similar molecular structures and distinct biologic effects in triple-negative breast cancer to identify targetable signaling pathways.
Anti-cancer drugs 09, 2020 | Pubmed ID: 32796402
ERK5 Is Required for Tumor Growth and Maintenance Through Regulation of the Extracellular Matrix in Triple Negative Breast Cancer.
Frontiers in oncology , 2020 | Pubmed ID: 32850332
Evaluation of deacetylase inhibition in metaplastic breast carcinoma using multiple derivations of preclinical models of a new patient-derived tumor.
PloS one , 2020 | Pubmed ID: 33035223
Molecular Mechanisms of Epithelial to Mesenchymal Transition Regulated by ERK5 Signaling.
Biomolecules Jan, 2021 | Pubmed ID: 33572742
Targeting Never-In-Mitosis-A Related Kinase 5 in Cancer: A Review.
Current medicinal chemistry Mar, 2021 | Pubmed ID: 33749548
Diverse and converging roles of ERK1/2 and ERK5 pathways on mesenchymal to epithelial transition in breast cancer.
Translational oncology Mar, 2021 | Pubmed ID: 33761370
Application of a small molecule inhibitor screen approach to identify CXCR4 downstream signaling pathways that promote a mesenchymal and fulvestrant-resistant phenotype in breast cancer cells.
Oncology letters May, 2021 | Pubmed ID: 33777204
Patient-Derived Xenografts as an Innovative Surrogate Tumor Model for the Investigation of Health Disparities in Triple Negative Breast Cancer.
Women's health reports (New Rochelle, N.Y.) , 2020 | Pubmed ID: 33786503
EVALUATION OF EXTRACELLULAR MATRIX COMPOSITION TO IMPROVE BREAST CANCER MODELING.
Tissue engineering. Part A Apr, 2021 | Pubmed ID: 33797977
Dual inhibition of MEK1/2 and MEK5 suppresses the EMT/migration axis in triple-negative breast cancer through FRA-1 regulation.
Journal of cellular biochemistry Apr, 2021 | Pubmed ID: 33876843
Loren M. Brown1,
Katherine L. Hebert2,
Rakesh R. Gurrala3,
C. Ethan Byrne4,
Matthew Burow5,
Elizabeth C. Martin4,
Frank H. Lau1
1Department of Surgery, Louisiana State University Health Sciences Center,
2Department of Bioinnovation, Tulane University,
3, Tulane University School of Medicine,
4Department of Biological and Agricultural Engineering, Louisiana State University,
5Department of Medicine, Tulane University School of Medicine
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