Robert J. Crouch

Isolation of RNase H genes that are essential for growth of Bacillus subtilis 168.

Quantitative regulation of class switch recombination by switch region transcription.

Multiple ribonuclease H-encoding genes in the Caenorhabditis elegans genome contrasts with the two typical ribonuclease H-encoding genes in the human genome.

Failure to produce mitochondrial DNA results in embryonic lethality in Rnaseh1 null mice.

RNase H2 of Saccharomyces cerevisiae is a complex of three proteins.

Eukaryotic RNases H1 act processively by interactions through the duplex RNA-binding domain.

Crystal structures of RNase H bound to an RNA/DNA hybrid: substrate specificity and metal-dependent catalysis.

Structure of human RNase H1 complexed with an RNA/DNA hybrid: insight into HIV reverse transcription.

Specific recognition of RNA/DNA hybrid and enhancement of human RNase H1 activity by HBD.

Ribonuclease H: the enzymes in eukaryotes.

Mammalian mitochondrial DNA replication intermediates are essentially duplex but contain extensive tracts of RNA/DNA hybrid.

An upstream open reading frame and the context of the two AUG codons affect the abundance of mitochondrial and nuclear RNase H1.

Crystal structures of RNase H2 in complex with nucleic acid reveal the mechanism of RNA-DNA junction recognition and cleavage.

The structural and biochemical characterization of human RNase H2 complex reveals the molecular basis for substrate recognition and Aicardi-Goutières syndrome defects.

Molecular biology. A new twist for topoisomerase.

Targeted deletion of the gene encoding the La autoantigen (Sjögren's syndrome antigen B) in B cells or the frontal brain causes extensive tissue loss.

Primer retention owing to the absence of RNase H1 is catastrophic for mitochondrial DNA replication.

Unlocking the steric gate of DNA polymerase η leads to increased genomic instability in Saccharomyces cerevisiae.

RNase H2 catalytic core Aicardi-Goutières syndrome-related mutant invokes cGAS-STING innate immune-sensing pathway in mice.

The Balancing Act of Ribonucleotides in DNA.

Pathological ribonuclease H1 causes R-loop depletion and aberrant DNA segregation in mitochondria.

R-Loop Depletion by Over-expressed RNase H1 in Mouse B Cells Increases Activation-Induced Deaminase Access to the Transcribed Strand without Altering Frequency of Isotype Switching.

Effects of neutral salts and pH on the activity and stability of human RNase H2.

Abasic and oxidized ribonucleotides embedded in DNA are processed by human APE1 and not by RNase H2.

Two RNase H2 Mutants with Differential rNMP Processing Activity Reveal a Threshold of Ribonucleotide Tolerance for Embryonic Development.

Aicardi-Goutières syndrome gene Rnaseh2c is a metastasis susceptibility gene in breast cancer.

Unlike the counterpart, archaeal RNase HII cannot process ribose monophosphate abasic sites and oxidized ribonucleotides embedded in DNA.

Characterization of six recombinant human RNase H2 bearing Aicardi-Goutiéres syndrome causing mutations.

RNases H: Multiple roles in maintaining genome integrity.

RNase H2-RED carpets the path to eukaryotic RNase H2 functions.

Val143 of human ribonuclease H2 is not critical for, but plays a role in determining catalytic activity and substrate specificity.

High density of unrepaired genomic ribonucleotides leads to Topoisomerase 1-mediated severe growth defects in absence of ribonucleotide reductase.