Frank J.T Staal

Endothelial progenitor cell dysfunction in type 1 diabetes: another consequence of oxidative stress?

Wnt signaling in hematopoiesis: crucial factors for self-renewal, proliferation, and cell fate decisions.

Genome-wide expression analysis of paired diagnosis-relapse samples in ALL indicates involvement of pathways related to DNA replication, cell cycle and DNA repair, independent of immune phenotype.

Stem cell self-renewal: lessons from bone marrow, gut and iPS toward clinical applications.

Wnt signaling strength regulates normal hematopoiesis and its deregulation is involved in leukemia development.

Morbidly obese human subjects have increased peripheral blood CD4+ T cells with skewing toward a Treg- and Th2-dominated phenotype.

Wnt cross-talk in the niche.

Induced pluripotent stem cells and severe combined immunodeficiency: merely disease modeling or potentially a novel cure?

Differential requirements for Wnt and Notch signaling in hematopoietic versus thymic niches.

Tales of the unexpected: Tcf1 functions as a tumor suppressor for leukemias.

The nuclear effector of Wnt-signaling, Tcf1, functions as a T-cell-specific tumor suppressor for development of lymphomas.

Alternative splicing and differential expression of the islet autoantigen IGRP between pancreas and thymus contributes to immunogenicity of pancreatic islets but not diabetogenicity in humans.

Wnt signaling in leukemias and myeloma: T-cell factors are in control.

Hematopoietic microRNA-126 protects against renal ischemia/reperfusion injury by promoting vascular integrity.

Somatic mutations found in the healthy blood compartment of a 115-yr-old woman demonstrate oligoclonal hematopoiesis.

Sustained Engraftment of Cryopreserved Human Bone Marrow CD34(+) Cells in Young Adult NSG Mice.

TCF-1-mediated Wnt signaling regulates Paneth cell innate immune defense effectors HD-5 and -6: implications for Crohn's disease.

Successful RAG1-SCID gene therapy depends on the level of RAG1 expression.

T Cell factor 1 represses CD8+ effector T cell formation and function.

Identification of checkpoints in human T-cell development using severe combined immunodeficiency stem cells.

The Quantity of Autocrine IL-2 Governs the Expansion Potential of CD8+ T Cells.

Development of a diverse human T-cell repertoire despite stringent restriction of hematopoietic clonality in the thymus.

Visualizing Human Hematopoietic Stem Cell Trafficking In Vivo Using a Zebrafish Xenograft Model.

The functional relationship between hematopoietic stem cells and developing T lymphocytes.

Caught in a Wnt storm: Complexities of Wnt signaling in hematopoiesis.

High Levels of Canonical Wnt Signaling Lead to Loss of Stemness and Increased Differentiation in Hematopoietic Stem Cells.

Overexpression of LMO2 causes aberrant human T-Cell development in vivo by three potentially distinct cellular mechanisms.

Aberrant Wnt Signaling in Leukemia.

Wnt signalling meets epigenetics.

Wnt Signaling as Master Regulator of T-Lymphocyte Responses: Implications for Transplant Therapy.

Loss of CD44 Expression from Early Progenitor Cells Marks T-Cell Lineage Commitment in the Human Thymus.

Activation of the oncogene through a somatically acquired neomorphic promoter in T-cell acute lymphoblastic leukemia.

The Effects of Selective Hematopoietic Expression of Human IL-37 on Systemic Inflammation and Atherosclerosis in LDLr-Deficient Mice.

Axin2-mTurquoise2: A novel reporter mouse model for the detection of canonical Wnt signalling.

B-1 cells and B-1 cell precursors prompt different responses to Wnt signaling.

JDP2: An oncogenic bZIP transcription factor in T cell acute lymphoblastic leukemia.

Cell intrinsic regulation of external hematopoietic stem cell stress.

Ex Vivo Expansion of Hematopoietic Stem Cells for Therapeutic Purposes: Lessons from Development and the Niche.

Gfi1b regulates the level of Wnt/β-catenin signaling in hematopoietic stem cells and megakaryocytes.

De novo generation of a functional human thymus from induced pluripotent stem cells.

ImSpectR - R package to quantify immune repertoire diversity in spectratype and repertoire sequencing data.

Autologous Stem-Cell-Based Gene Therapy for Inherited Disorders: State of the Art and Perspectives.

An Integrated Gene Expression Landscape Profiling Approach to Identify Lung Tumor Endothelial Cell Heterogeneity and Angiogenic Candidates.

iPSC-Based Modeling of RAG2 Severe Combined Immunodeficiency Reveals Multiple T Cell Developmental Arrests.

Single-Cell RNA Sequencing Maps Endothelial Metabolic Plasticity in Pathological Angiogenesis.

Successful Preclinical Development of Gene Therapy for Recombinase-Activating Gene-1-Deficient SCID.

Preclinical Development of Autologous Hematopoietic Stem Cell-Based Gene Therapy for Immune Deficiencies: A Journey from Mouse Cage to Bed Side.

Functional definition of a transcription factor hierarchy regulating T cell lineage commitment.

An adequate human T cell repertoire from a single T cell progenitor: Lessons from an experiment of nature.

Blocking of the High-Affinity Interaction-Synapse Between SARS-CoV-2 Spike and Human ACE2 Proteins Likely Requires Multiple High-Affinity Antibodies: An Immune Perspective.

Cell Signaling Pathway Reporters in Adult Hematopoietic Stem Cells.

Dynamic clonal hematopoiesis and functional T-cell immunity in a supercentenarian.

A Novel Branched DNA-Based Flowcytometric Method for Single-Cell Characterization of Gene Therapy Products and Expression of Therapeutic Genes.

Inflammation and Wnt Signaling: Target for Immunomodulatory Therapy?

Corrigendum: Blocking of the High-Affinity Interaction-Synapse Between SARS-CoV-2 Spike and Human ACE2 Proteins Likely Requires Multiple High-Affinity Antibodies: An Immune Perspective.

The Route of Early T Cell Development: Crosstalk between Epigenetic and Transcription Factors.

Combining Mobilizing Agents with Busulfan to Reduce Chemotherapy-Based Conditioning for Hematopoietic Stem Cell Transplantation.

A DL-4- and TNFα-based culture system to generate high numbers of nonmodified or genetically modified immunotherapeutic human T-lymphoid progenitors.

Predicting genotoxicity of viral vectors for stem cell gene therapy using gene expression-based machine learning.