James Martin Stem Cell Facility,
Sir William Dunn School of Pathology,
James Martin Stem Cell Facility, Sir William Dunn School of Pathology
http://www.wsjlab.com/meet-the-lab/sally-cowley/
Derivation and characterisation of the human embryonic stem cell line, OxF1.
In vitro cellular & developmental biology. Animal Apr, 2010 | Pubmed ID: 20333479
Protein kinase C and NF-κB-dependent CD4 downregulation in macrophages induced by T cell-derived soluble factors: consequences for HIV-1 infection.
Journal of immunology (Baltimore, Md. : 1950) Jul, 2011 | Pubmed ID: 21666058
Episomal transgene expression in pluripotent stem cells.
Methods in molecular biology (Clifton, N.J.) , 2011 | Pubmed ID: 21822889
Transportin 3 promotes a nuclear maturation step required for efficient HIV-1 integration.
PLoS pathogens Aug, 2011 | Pubmed ID: 21901095
Cellular reprogramming: a new approach to modelling Parkinson's disease.
Biochemical Society transactions Oct, 2012 | Pubmed ID: 22988881
Differentially expressed, variant U1 snRNAs regulate gene expression in human cells.
Genome research Feb, 2013 | Pubmed ID: 23070852
Efficient, long term production of monocyte-derived macrophages from human pluripotent stem cells under partly-defined and fully-defined conditions.
PloS one , 2013 | Pubmed ID: 23951090
The productive entry pathway of HIV-1 in macrophages is dependent on endocytosis through lipid rafts containing CD4.
PloS one , 2014 | Pubmed ID: 24465876
Physiological characterisation of human iPS-derived dopaminergic neurons.
PloS one , 2014 | Pubmed ID: 24586273
CRISPR-mediated genotypic and phenotypic correction of a chronic granulomatous disease mutation in human iPS cells.
Experimental hematology Oct, 2015 | Pubmed ID: 26101162
The Current State of Naïve Human Pluripotency.
Stem cells (Dayton, Ohio) Nov, 2015 | Pubmed ID: 26119873
ER Stress and Autophagic Perturbations Lead to Elevated Extracellular α-Synuclein in GBA-N370S Parkinson's iPSC-Derived Dopamine Neurons.
Stem cell reports Mar, 2016 | Pubmed ID: 26905200
C9orf72 Hexanucleotide Expansions Are Associated with Altered Endoplasmic Reticulum Calcium Homeostasis and Stress Granule Formation in Induced Pluripotent Stem Cell-Derived Neurons from Patients with Amyotrophic Lateral Sclerosis and Frontotemporal Dementia.
Stem cells (Dayton, Ohio) 08, 2016 | Pubmed ID: 27097283
Variant U1 snRNAs are implicated in human pluripotent stem cell maintenance and neuromuscular disease.
Nucleic acids research 12, 2016 | Pubmed ID: 27536002
Transcriptomic profiling of purified patient-derived dopamine neurons identifies convergent perturbations and therapeutics for Parkinson's disease.
Human molecular genetics 02, 2017 | Pubmed ID: 28096185
Multiplex High-Throughput Targeted Proteomic Assay To Identify Induced Pluripotent Stem Cells.
Analytical chemistry 02, 2017 | Pubmed ID: 28192931
LRRK2 in peripheral and central nervous system innate immunity: its link to Parkinson's disease.
Biochemical Society transactions Feb, 2017 | Pubmed ID: 28202666
A Highly Efficient Human Pluripotent Stem Cell Microglia Model Displays a Neuronal-Co-culture-Specific Expression Profile and Inflammatory Response.
Stem cell reports 06, 2017 | Pubmed ID: 28591653
MAPT Genetic Variation and Neuronal Maturity Alter Isoform Expression Affecting Axonal Transport in iPSC-Derived Dopamine Neurons.
Stem cell reports 08, 2017 | Pubmed ID: 28689993
Excess α-synuclein compromises phagocytosis in iPSC-derived macrophages.
Scientific reports 08, 2017 | Pubmed ID: 28827786
Alpha-synuclein induces the unfolded protein response in Parkinson's disease SNCA triplication iPSC-derived neurons.
Human molecular genetics 11, 2017 | Pubmed ID: 28973645
A Simplified Method for Generating Purkinje Cells from Human-Induced Pluripotent Stem Cells.
Cerebellum (London, England) Aug, 2018 | Pubmed ID: 29397531
Stem cell modeling of mitochondrial parkinsonism reveals key functions of OPA1.
Annals of neurology 05, 2018 | Pubmed ID: 29604226
LRRK2 is a negative regulator of phagosome maturation in macrophages.
The EMBO journal Jun, 2018 | Pubmed ID: 29789389
FRMD8 promotes inflammatory and growth factor signalling by stabilising the iRhom/ADAM17 sheddase complex.
eLife 06, 2018 | Pubmed ID: 29897336
Genome editing in induced pluripotent stem cells rescues TAF1 levels in X-linked dystonia-parkinsonism.
Movement disorders : official journal of the Movement Disorder Society 07, 2018 | Pubmed ID: 30153385
Neurodegeneration in SCA14 is associated with increased PKCγ kinase activity, mislocalization and aggregation.
Acta neuropathologica communications 09, 2018 | Pubmed ID: 30249303
RIPK1 is a critical modulator of both tonic and TLR-responsive inflammatory and cell death pathways in human macrophage differentiation.
Cell death & disease 09, 2018 | Pubmed ID: 30250197
Single-Cell Sequencing of iPSC-Dopamine Neurons Reconstructs Disease Progression and Identifies HDAC4 as a Regulator of Parkinson Cell Phenotypes.
Cell stem cell 01, 2019 | Pubmed ID: 30503143
Microglial inflammation and phagocytosis in Alzheimer's disease: Potential therapeutic targets.
British journal of pharmacology 09, 2019 | Pubmed ID: 30740661
Cellular α-synuclein pathology is associated with bioenergetic dysfunction in Parkinson's iPSC-derived dopamine neurons.
Human molecular genetics 06, 2019 | Pubmed ID: 30753527
Proteolytic shedding of the prion protein via activation of metallopeptidase ADAM10 reduces cellular binding and toxicity of amyloid-β oligomers.
The Journal of biological chemistry 04, 2019 | Pubmed ID: 30872401
An integrated transcriptomics and proteomics analysis reveals functional endocytic dysregulation caused by mutations in LRRK2.
Neurobiology of disease 07, 2019 | Pubmed ID: 30954703
Lentiviral gene therapy vector with UCOE stably restores function in iPSC-derived neutrophils of a CDG patient.
Matters , 2018 | Pubmed ID: 31008103
RNA sequencing reveals MMP2 and TGFB1 downregulation in LRRK2 G2019S Parkinson's iPSC-derived astrocytes.
Neurobiology of disease 09, 2019 | Pubmed ID: 31085228
Application of CRISPR/Cas9 editing and digital droplet PCR in human iPSCs to generate novel knock-in reporter lines to visualize dopaminergic neurons.
Stem cell research 12, 2019 | Pubmed ID: 31733438
A causal role for TRESK loss of function in migraine mechanisms.
Brain : a journal of neurology 12, 2019 | Pubmed ID: 31742594
Impairment of Mitochondrial Calcium Buffering Links Mutations in C9ORF72 and TARDBP in iPS-Derived Motor Neurons from Patients with ALS/FTD.
Stem cell reports 05, 2020 | Pubmed ID: 32330447
LRRK2 Is Recruited to Phagosomes and Co-recruits RAB8 and RAB10 in Human Pluripotent Stem Cell-Derived Macrophages.
Stem cell reports 05, 2020 | Pubmed ID: 32359446
Patient fibroblast circadian rhythms predict lithium sensitivity in bipolar disorder.
Molecular psychiatry May, 2020 | Pubmed ID: 32404948
Generation of twenty four induced pluripotent stem cell lines from twenty four members of the Lothian Birth Cohort 1936.
Stem cell research 07, 2020 | Pubmed ID: 32450543
Correction of amyotrophic lateral sclerosis related phenotypes in induced pluripotent stem cell-derived motor neurons carrying a hexanucleotide expansion mutation in C9orf72 by CRISPR/Cas9 genome editing using homology-directed repair.
Human molecular genetics Aug, 2020 | Pubmed ID: 32504093
Rates of homology directed repair of CRISPR-Cas9 induced double strand breaks are lower in naïve compared to primed human pluripotent stem cells.
Stem cell research 07, 2020 | Pubmed ID: 32521498
Profiling of naïve and primed human pluripotent stem cells reveals state-associated miRNAs.
Scientific reports 06, 2020 | Pubmed ID: 32601281
Large-Scale Production of Human iPSC-Derived Macrophages for Drug Screening.
International journal of molecular sciences Jul, 2020 | Pubmed ID: 32645954
ADAM17-triggered TNF signalling protects the ageing Drosophila retina from lipid droplet-mediated degeneration.
The EMBO journal Sep, 2020 | Pubmed ID: 32715522
TREM2 Alzheimer's variant R47H causes similar transcriptional dysregulation to knockout, yet only subtle functional phenotypes in human iPSC-derived macrophages.
Alzheimer's research & therapy 11, 2020 | Pubmed ID: 33198789
Honing the Double-Edged Sword: Improving Human iPSC-Microglia Models.
Frontiers in immunology , 2020 | Pubmed ID: 33363548
Tissue-resident macrophages regulate lymphatic vessel growth and patterning in the developing heart.
Development (Cambridge, England) Feb, 2021 | Pubmed ID: 33462113
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