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Intraoperative Assessment of Resection Margins in Oral Cavity Cancer: This is the Way

The goal of head and neck oncological surgery is complete tumor resection with adequate resection margins while preserving acceptable function and ...

Erasmus MC University Medical Center

Early laryngeal cancer is treated with surgery or radiotherapy. A partial laryngectomy instead of a total laryngectomy can be used for treating patients with radiation failures.

Partial laryngectomy for recurrent glottic carcinoma after radiotherapy.

To investigate the quality of life after partial laryngectomy versus total laryngectomy for recurrent laryngeal carcinomas after radiotherapy.

Surgery for recurrent laryngeal carcinoma after radiotherapy: partial laryngectomy or total laryngectomy for a better quality of life?

Although organ preservation can be achieved with chemoradiation protocols for laryngeal or pharyngeal cancers, salvage surgery is accompanied by high complication rates.

High complication risk of salvage surgery after chemoradiation failures.

Specimen-driven intraoperative assessment of the resection margins provides immediate feedback if an additional excision is needed. However, relocation of an inadequate margin in the wound bed has shown to be difficult. The objective of this study is to assess a reliable method for accurate relocation of inadequate tumor resection margins in the wound bed after intraoperative assessment of the specimen.

Relocation of inadequate resection margins in the wound bed during oral cavity oncological surgery: A feasibility study.

Treatment of hypopharyngeal cancer depends on the extent and location of the tumour, patient-specific or by factors (age, performance status, co-morbidity) and the presence of psychosocial support. Options available for the treatment of hypopharyngeal cancer consist of surgery and non-surgery - radiotherapy, chemoradiation, bioradiation, or a combination of these modalities. To maintain normal functioning as much as possible, functional organ preservation is widely recommended and generally utilizes radiotherapy and/or chemoradiation. Although functional organ-sparing approaches can permit larynx preservation in patients with locoregionally advanced cancer of the hypopharynx, they do not provide a survival advantage over total laryngectomy. All available treatment modalities for patients with hypopharyngeal cancer have associated short- and long-term toxicities leading to side effects and complications.

Sequelae and Complications of Treatment for Hypopharyngeal Cancer: Minimising the Risks.

Depth of invasion (DOI) is the most important predictor for lymph node metastasis (LNM) in early stage (T1-T2) oral cancer. The aim of this study is to validate the cut-off value of 4 mm on which the decision to perform an Elective Neck Dissection (END) is made.

Aniel Sewnaik

Department of Otorhinolaryngology and Head and Neck Surgery

Erasmus MC University Medical Center

Intraoperative Assessment of Resection Margins in Oral Cavity Cancer: This is the Way