Gregory D. Horwitz

Washington National Primate Research Center,
Dept. of Physiology & Biophysics

University of Washington

BIOGRAPHY

Greg Horwitz is a Professor in the Department of Physiology and Biophysics at the University of Washington and serves as the Chief of the Neuroscience Division at the Washington National Primate Research Center. He received his undergraduate degree from Harvard University and a Ph.D. from Stanford University.

Research in the Horwitz lab focuses on the neurobiological basis of vision and visually guided behavior. Of particular interest are the mechanisms that limit the sensation of flicker and the circuitry by which signals from the cone photoreceptors are combined in the visual cortex. Recently completed projects in Dr. Horwitz's laboratory have refined new genetic tools for the manipulation of neural activity in non-human primates, and ongoing projects continue to extend this toolkit. A critical component of this work is the validation of new viral vectors that target specific cell types.

PUBLICATIONS

Advances in color science: from retina to behavior.

The Journal of neuroscience : the official journal of the Society for Neuroscience Nov, 2010 | Pubmed ID: 21068298

Effects of microsaccades on contrast detection and V1 responses in macaques.

Journal of vision Mar, 2011 | Pubmed ID: 21378110

Nonlinear analysis of macaque V1 color tuning reveals cardinal directions for cortical color processing.

Nature neuroscience Jun, 2012 | Pubmed ID: 22581184

Saccadic eye movements evoked by optogenetic activation of primate V1.

Nature neuroscience Oct, 2012 | Pubmed ID: 22941109

V1 mechanisms underlying chromatic contrast detection.

Journal of neurophysiology May, 2013 | Pubmed ID: 23446689

Object-centered shifts of receptive field positions in monkey primary visual cortex.

Current biology : CB Jul, 2014 | Pubmed ID: 25017208

Spectral sensitivity differences between rhesus monkeys and humans: implications for neurophysiology.

Journal of neurophysiology Dec, 2014 | Pubmed ID: 25253473

What studies of macaque monkeys have told us about human color vision.

Neuroscience Jun, 2015 | Pubmed ID: 25445192

Chromatic detection from cone photoreceptors to V1 neurons to behavior in rhesus monkeys.

Journal of vision , 2015 | Pubmed ID: 26523737

Strategies for targeting primate neural circuits with viral vectors.

Journal of neurophysiology 07, 2016 | Pubmed ID: 27052579

AAV-mediated delivery of optogenetic constructs to the macaque brain triggers humoral immune responses.

Journal of neurophysiology 05, 2017 | Pubmed ID: 28202570

Selective Optogenetic Control of Purkinje Cells in Monkey Cerebellum.

Neuron Jul, 2017 | Pubmed ID: 28648497

Measurements of neuronal color tuning: Procedures, pitfalls, and alternatives.

Vision research 10, 2018 | Pubmed ID: 29133032

Dethroning the Fano Factor: A Flexible, Model-Based Approach to Partitioning Neural Variability.

Neural computation 04, 2018 | Pubmed ID: 29381442

Focal optogenetic suppression in macaque area MT biases direction discrimination and decision confidence, but only transiently.

eLife 07, 2018 | Pubmed ID: 30051817

Model of parafoveal chromatic and luminance temporal contrast sensitivity of humans and monkeys.

Journal of vision 11, 2018 | Pubmed ID: 30383213

Primate optogenetics: Progress and prognosis.

Proceedings of the National Academy of Sciences of the United States of America Dec, 2019 | Pubmed ID: 31871196

Temporal information loss in the macaque early visual system.

PLoS biology 01, 2020 | Pubmed ID: 31971946

Fast and reversible neural inactivation in macaque cortex by optogenetic stimulation of GABAergic neurons.

eLife 05, 2020 | Pubmed ID: 32452766

Viral Vectors for Neural Circuit Mapping and Recent Advances in Trans-synaptic Anterograde Tracers.

Neuron 09, 2020 | Pubmed ID: 32755550

Signals Related to Color in the Early Visual Cortex.

Annual review of vision science 09, 2020 | Pubmed ID: 32936735

Spatial receptive field structure of double-opponent cells in macaque V1.

Journal of neurophysiology 03, 2021 | Pubmed ID: 33405995

Functional enhancer elements drive subclass-selective expression from mouse to primate neocortex.

Cell reports Mar, 2021 | Pubmed ID: 33789096

Temporal filtering of luminance and chromaticity in macaque visual cortex.

iScience Jun, 2021 | Pubmed ID: 34189430

Windows and periscopes into primate behavior.

Cell reports Jul, 2021 | Pubmed ID: 34289362

INSTITUTIONS

University of Washington

JOVE ARTICLES

Injections of AAV Vectors for Optogenetics in Anesthetized and Awake Behaving Non-Human Primate Brain

Yoshiko Kojima^1,2,

Jonathan T. Ting^2,3,4,

Robijanto Soetedjo^2,4,

Shane D. Gibson^2,4,

Gregory D. Horwitz^2,4

¹Dept. of Otolaryngology - Head and Neck Surgery, University of Washington,

²Washington National Primate Research Center, University of Washington,

³, Allen Institute for Brain Science,

⁴Dept. of Physiology & Biophysics, University of Washington

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Gregory D. Horwitz

.css-o250i3{font-size:18px;font-family:Open Sans,sans-serif;line-height:21.6px;}Washington National Primate Research Center,Dept. of Physiology & Biophysics

University of Washington

Injections of AAV Vectors for Optogenetics in Anesthetized and Awake Behaving Non-Human Primate Brain

Washington National Primate Research Center,
Dept. of Physiology & Biophysics