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Brain Science Institute,
Department of Neurology
Alyssa N. Coyne has not added Biography.
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Drosophila models of amyotrophic lateral sclerosis with defects in RNA metabolism.
Brain research 08, 2018 | Pubmed ID: 29752901
CRISPR-Cas9 Screens Identify the RNA Helicase DDX3X as a Repressor of C9ORF72 (GGGGCC)n Repeat-Associated Non-AUG Translation.
Neuron 12, 2019 | Pubmed ID: 31587919
GC Repeat RNA Initiates a POM121-Mediated Reduction in Specific Nucleoporins in C9orf72 ALS/FTD.
Neuron 09, 2020 | Pubmed ID: 32673563
Nuclear lamina invaginations are not a pathological feature of C9orf72 ALS/FTD.
Acta neuropathologica communications 03, 2021 | Pubmed ID: 33741069
UPF1 reduces C9orf72 HRE-induced neurotoxicity in the absence of nonsense-mediated decay dysfunction.
Cell reports Mar, 2021 | Pubmed ID: 33789100
The ESCRT-III protein VPS4, but not CHMP4B or CHMP2B, is pathologically increased in familial and sporadic ALS neuronal nuclei.
Acta neuropathologica communications 07, 2021 | Pubmed ID: 34281622
Nuclear accumulation of CHMP7 initiates nuclear pore complex injury and subsequent TDP-43 dysfunction in sporadic and familial ALS.
Science translational medicine 07, 2021 | Pubmed ID: 34321318
Johns Hopkins University School of Medicine
Alyssa N. Coyne1,2,
Jeffrey D. Rothstein1,2
1Brain Science Institute, Johns Hopkins University School of Medicine,
2Department of Neurology, Johns Hopkins University School of Medicine
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