ultrasonic-assisted-extraction-cannabidiolic-acid-from-cannabis

Ultrasonic-Assisted Extraction of Cannabidiolic Acid from <em>Cannabis</em> Biomass

Industrial hemp (Cannabis spp.) has many compounds of interest with potential medical benefits. Of these compounds, cannabinoids have come to the center ...

Chuncheon Bioindustry Foundation

γ-Poly-Glutamic Acid (γ-PGA) is a naturally occurring homo-polyamide produced by various strains of Bacillus. It is made from repeating units of L-glutamic acid, D-glutamic acid, or both connected through amide linkages between α-amino and γ-carboxylic acid groups. As a biopolymer substance, the attractive properties of γ-PGA are that it is water-soluble, biodegradable, biocompatible, non-toxic, non-immunogenic, and edible. Therefore, it can be used as a green and environmentally friendly biological material.

Applications and Functions of γ-Poly-Glutamic Acid and its Derivatives in Medicine.

 root is traditionally known to be effective in the treatment of diabetes in Korea.  root-specific compounds also show antioxidant effects, and could reduce lipid and fat accumulation, however, the underlying mechanism has not been clarified. In present study, the antioxidant and lipid-reducing effects of a 50% ethanol extract of  (REE) were investigated differentiated mouse preadipocytes (3T3-L1 cells). REE showed strong radical scavenging activities and inhibitory effect of total lipid accumulation and triglyceride levels in differentiated 3T3-L1 cells. In addition, REE treatment reduced the mRNA and protein levels of adipogenesis and lipogenesis markers. This REE-promoted lipid reduction was caused by downregulation of peroxisome proliferator activated receptor gamma (), CCAAT/enhancer binding protein alpha (), and sterol regulatory element binding protein1 () and down regulation of ERK expression. Overall, these results demonstrate the potential of REE for development of a drug in the medical treatment of lipid-associated disorders.

Soo-Ung Lee

Chuncheon Bioindustry Foundation

Ultrasonic-Assisted Extraction of Cannabidiolic Acid from Cannabis Biomass