Mohammad F. Kiani
Department of Mechanical Engineering,
Department of Bioengineering,
Department of Radiation Oncology,
Lewis Katz School of Medicine,
Department of Radiation Oncology, Lewis Katz School of Medicine
Temple University
Dr. Mohammad F. Kiani is a professor in the Department of Mechanical Engineering, with joint appointments in the Department of Bioengineering and Department of Radiation Oncology, at Temple University. He served as the chair of Department of Mechanical Engineering at Temple University (2004-2014) and Department of Biomedical Engineering at the University of Tennessee Health Science Center (2003-2004). He received a B.S. in electrical engineering from the University of Oklahoma and M.S. and Ph.D. in biomedical engineering from Louisiana Tech University. He was an NIH postdoctoral fellow at the University of Rochester from 1990 to 1993. The current focus of his research is the development of organoids and microphysiological systems for rapid drug development and screening and targeted drug delivery.
Targeting of the antivascular drug combretastatin to irradiated tumors results in tumor growth delay.
Pharmaceutical research Jul, 2005 | Pubmed ID: 16028012
Local and average gloss from flat-faced sodium chloride tablets.
AAPS PharmSciTech Jan, 2006 | Pubmed ID: 16584166
Targeted delivery of antibody conjugated liposomal drug carriers to rat myocardial infarction.
Biotechnology and bioengineering Mar, 2007 | Pubmed ID: 17051598
Anti-TNFA (TNF-alpha) treatment abrogates radiation-induced changes in vacular density and tissue oxygenation.
Radiation research Jan, 2007 | Pubmed ID: 17243316
Microvascular transport model predicts oxygenation changes in the infarcted heart after treatment.
American journal of physiology. Heart and circulatory physiology Dec, 2007 | Pubmed ID: 17951368
Modeling oxygenation and selective delivery of drug carriers post-myocardial infarction.
Advances in experimental medicine and biology , 2008 | Pubmed ID: 18290344
Synthetic microvascular networks for quantitative analysis of particle adhesion.
Biomedical microdevices Aug, 2008 | Pubmed ID: 18327641
Aiming for the heart: targeted delivery of drugs to diseased cardiac tissue.
Expert opinion on drug delivery Apr, 2008 | Pubmed ID: 18426386
Radiation-guided targeting of combretastatin encapsulated immunoliposomes to mammary tumors.
Pharmaceutical research May, 2009 | Pubmed ID: 19172383
A physiologically realistic in vitro model of microvascular networks.
Biomedical microdevices Oct, 2009 | Pubmed ID: 19452279
Targeting VEGF-encapsulated immunoliposomes to MI heart improves vascularity and cardiac function.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology Oct, 2009 | Pubmed ID: 19535683
Preferential adhesion of leukocytes near bifurcations is endothelium independent.
Microvascular research Dec, 2010 | Pubmed ID: 20624406
Towards a targeted multi-drug delivery approach to improve therapeutic efficacy in breast cancer.
Expert opinion on drug delivery Oct, 2010 | Pubmed ID: 20738211
Bifurcations: focal points of particle adhesion in microvascular networks.
Microcirculation (New York, N.Y. : 1994) Jul, 2011 | Pubmed ID: 21418388
Microfluidic devices for modeling cell-cell and particle-cell interactions in the microvasculature.
Microvascular research Nov, 2011 | Pubmed ID: 21763328
Fourier transform infrared spectroscopic imaging of cardiac tissue to detect collagen deposition after myocardial infarction.
Journal of biomedical optics May, 2012 | Pubmed ID: 22612137
Cholesterol superlattice modulates CA4P release from liposomes and CA4P cytotoxicity on mammary cancer cells.
Biophysical journal May, 2012 | Pubmed ID: 22824272
Targeted Delivery of VEGF after a Myocardial Infarction Reduces Collagen Deposition and Improves Cardiac Function.
Cardiovascular engineering and technology Jun, 2012 | Pubmed ID: 22844388
Targeted delivery of VEGF to treat myocardial infarction.
Advances in experimental medicine and biology , 2013 | Pubmed ID: 22879049
Adhesive interaction of functionalized particles and endothelium in idealized microvascular networks.
Microvascular research Sep, 2013 | Pubmed ID: 23557880
Fourier transform infrared spectroscopy to quantify collagen and elastin in an in vitro model of extracellular matrix degradation in aorta.
The Analyst Jun, 2014 | Pubmed ID: 24761431
Targeted delivery of vascular endothelial growth factor improves stem cell therapy in a rat myocardial infarction model.
Nanomedicine : nanotechnology, biology, and medicine Nov, 2014 | Pubmed ID: 24941463
Bioinspired microfluidic assay for in vitro modeling of leukocyte-endothelium interactions.
Analytical chemistry Aug, 2014 | Pubmed ID: 25135319
Adhesion patterns in the microvasculature are dependent on bifurcation angle.
Microvascular research May, 2015 | Pubmed ID: 25708050
Correlations between transmural mechanical and morphological properties in porcine thoracic descending aorta.
Journal of the mechanical behavior of biomedical materials Jul, 2015 | Pubmed ID: 25837340
Fast, Stable Induction of P-Glycoprotein-mediated Drug Resistance in BT-474 Breast Cancer Cells by Stable Transfection of ABCB1 Gene.
Anticancer research May, 2015 | Pubmed ID: 25964526
A Novel Dynamic Neonatal Blood-Brain Barrier on a Chip.
PloS one , 2015 | Pubmed ID: 26555149
A novel microfluidic assay reveals a key role for protein kinase C δ in regulating human neutrophil-endothelium interaction.
Journal of leukocyte biology 11, 2016 | Pubmed ID: 27190303
Classification, Treatment Strategy, and Associated Drug Resistance in Breast Cancer.
Clinical breast cancer 10, 2016 | Pubmed ID: 27268750
Fourier Transform Infrared Spectroscopic Imaging-Derived Collagen Content and Maturity Correlates with Stress in the Aortic Wall of Abdominal Aortic Aneurysm Patients.
Cardiovascular engineering and technology 03, 2017 | Pubmed ID: 27995569
Targeted multidrug delivery system to overcome chemoresistance in breast cancer.
International journal of nanomedicine , 2017 | Pubmed ID: 28176940
A Biomimetic Microfluidic Tumor Microenvironment Platform Mimicking the EPR Effect for Rapid Screening of Drug Delivery Systems.
Scientific reports 08, 2017 | Pubmed ID: 28839211
Murine glomerular transcriptome links endothelial cell-specific molecule-1 deficiency with susceptibility to diabetic nephropathy.
PloS one , 2017 | Pubmed ID: 28934365
PKCδ inhibition as a novel medical countermeasure for radiation-induced vascular damage.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology Jun, 2018 | Pubmed ID: 29897816
Protein Kinase C-Delta (PKCδ) Tyrosine Phosphorylation is a Critical Regulator of Neutrophil-Endothelial Cell Interaction in Inflammation.
Shock (Augusta, Ga.) 05, 2019 | Pubmed ID: 30095599
Protein kinase C-delta inhibition protects blood-brain barrier from sepsis-induced vascular damage.
Journal of neuroinflammation Nov, 2018 | Pubmed ID: 30400800
The Role of Tyrosine Phosphorylation of Protein Kinase C Delta in Infection and Inflammation.
International journal of molecular sciences Mar, 2019 | Pubmed ID: 30917487
Reversible Cavitation-Induced Junctional Opening in an Artificial Endothelial Layer.
Small (Weinheim an der Bergstrasse, Germany) 12, 2019 | Pubmed ID: 31762158
Neutrophil-endothelial interactions of murine cells is not a good predictor of their interactions in human cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 02, 2020 | Pubmed ID: 31908006
Experimental Approaches to Evaluate Leukocyte-Endothelial Cell Interactions in Sepsis and Inflammation.
Shock (Augusta, Ga.) 05, 2020 | Pubmed ID: 32080065
Mechanisms of radiation-induced endothelium damage: Emerging models and technologies.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 05, 2021 | Pubmed ID: 33581220
Emerging Approaches to Understanding Microvascular Endothelial Heterogeneity: A Roadmap for Developing Anti-Inflammatory Therapeutics.
International journal of molecular sciences Jul, 2021 | Pubmed ID: 34360536
A Microphysiological System to Study Leukocyte-Endothelial Cell Interaction during Inflammation
Qingliang Yang1,
Jordan C. Langston2,
Yuan Tang3,
Balabhaskar Prabhakarpandian4,
Laurie E. Kilpatrick5,
Mohammad F. Kiani1,2,6
1Department of Mechanical Engineering, Temple University,
2Department of Bioengineering, Temple University,
3Department of Bioengineering, University of Toledo,
4Biomedical Technology, CFD Research Corporation,
5Center for Inflammation and Lung Research, Department of Microbiology, Immunology and Inflammation, Lewis Katz School of Medicine, Temple University,
6Department of Radiation Oncology, Lewis Katz School of Medicine, Temple University
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