Department of Dermatology,
National Cheng Kung University Hospital,
College of Medicine,
Department of Biochemistry and Molecular Biology,
Center of Applied Nanomedicine,
Department of Dermatology, National Cheng Kung University Hospital, College of Medicine,
Department of Biochemistry and Molecular Biology, College of Medicine
Professor Tak-Wah Wong MD, Ph.D. works in the Department of Dermatology, Department of Biochemistry and Molecular Biology, Center of Applied Nanomedicine, at the National Cheng Kung University Medical Center of Taiwan. He is one of the founding members and sits on the board of directors of the Taiwanese Society of Investigative Dermatology. Dr. Wong dedicates his research to photobiology, oncology, infectious diseases, wound healing, and abnormal scarring. As Taiwan’s pioneer in the use of photodynamic therapy (PDT) to treat skin cancer since 1999, he received a five-year physician-scientist grant in 2000 from Taiwan’s National Health Research Institute and spent two years as a visiting scientist with Professor Thomas Dougherty and Dr. Allan Oseroff’s team at the Roswell Park Cancer Institute PDT Center in New York. Since then, the research of PDT in his lab has been extended from neoplastic diseases to infectious diseases, wound healing, and aesthetic areas, recently discovering that PDT increases drug susceptibility to antibiotics. Working together with scientists in multidisciplinary research fields including medical engineering, nanotechnology, ophthalmology, microbiology, and immunology, Dr. Wong and his team are dedicated to advancing the basic research of PTD and its clinical applications.
Pilot study of topical delivery of mono-L-aspartyl chlorin e6 (NPe6): implication of topical NPe6-photodynamic therapy.
Journal of pharmacological sciences Oct, 2003 | Pubmed ID: 14578580
Modified Nile red staining method for improved visualization of neutral lipid depositions in stratum corneum.
Journal of the Formosan Medical Association = Taiwan yi zhi Sep, 2003 | Pubmed ID: 14625614
Histopathological differential diagnosis of keloid and hypertrophic scar.
The American Journal of dermatopathology Oct, 2004 | Pubmed ID: 15365369
Eosinophilic pustular folliculitis (Ofuji's disease) in a patient with silicone tissue augmentation.
The Journal of dermatology Sep, 2004 | Pubmed ID: 15628318
Bactericidal effects of toluidine blue-mediated photodynamic action on Vibrio vulnificus.
Antimicrobial agents and chemotherapy Mar, 2005 | Pubmed ID: 15728881
Detection of IL-20 and its receptors on psoriatic skin.
Clinical immunology (Orlando, Fla.) Oct, 2005 | Pubmed ID: 16043414
Painless electroporation with a new needle-free microelectrode array to enhance transdermal drug delivery.
Journal of controlled release : official journal of the Controlled Release Society Feb, 2006 | Pubmed ID: 16356576
Enhancing transdermal drug delivery with electroporation.
Recent patents on drug delivery & formulation , 2008 | Pubmed ID: 19075897
Molecular mimicry between streptococcal pyrogenic exotoxin B and endothelial cells.
Laboratory investigation; a journal of technical methods and pathology Oct, 2010 | Pubmed ID: 20458278
Methylene blue-mediated photodynamic inactivation as a novel disinfectant of enterovirus 71.
The Journal of antimicrobial chemotherapy Oct, 2010 | Pubmed ID: 20719762
Painless skin electroporation as a novel way for insulin delivery.
Diabetes technology & therapeutics Sep, 2011 | Pubmed ID: 21599516
Solanum incanum extract (SR-T100) induces human cutaneous squamous cell carcinoma apoptosis through modulating tumor necrosis factor receptor signaling pathway.
Journal of dermatological science Aug, 2011 | Pubmed ID: 21612892
Inhibiting glycogen synthase kinase-3 decreases 12-O-tetradecanoylphorbol-13-acetate-induced interferon-γ-mediated skin inflammation.
The Journal of pharmacology and experimental therapeutics Oct, 2012 | Pubmed ID: 22773863
Early intervention with high-dose steroid pulse therapy prolongs disease-free interval of severe alopecia areata: a retrospective study.
Annals of dermatology Nov, 2013 | Pubmed ID: 24371395
Complete remission of a periorbital dermatofibrosarcoma protuberans with adjuvant imatinib mesylate in a child.
JAAD case reports Jul, 2015 | Pubmed ID: 27051721
Enhancement of Wound Healing by Non-Thermal N2/Ar Micro-Plasma Exposure in Mice with Fractional-CO2-Laser-Induced Wounds.
PloS one , 2016 | Pubmed ID: 27248979
Successful treatment of cutaneous squamous cell carcinoma with intralesional cryosurgery: Case report.
Medicine Sep, 2016 | Pubmed ID: 27684856
Effects of blue or violet light on the inactivation of Staphylococcus aureus by riboflavin-5'-phosphate photolysis.
Journal of photochemistry and photobiology. B, Biology Aug, 2017 | Pubmed ID: 28715781
Never too old to regenerate? Wound induced hair follicle neogenesis after secondary intention healing in a geriatric patient.
Journal of tissue viability May, 2018 | Pubmed ID: 29310861
Efficacy and safety of topical SR-T100 gel in treating actinic keratosis in Taiwan: A Phase III randomized double-blind vehicle-controlled parallel trial.
Journal of dermatological science Jun, 2018 | Pubmed ID: 29530340
Effects of Blue-Light-Induced Free Radical Formation from Catechin Hydrate on the Inactivation of Including a Carbapenem-Resistant Strain.
Molecules (Basel, Switzerland) 07, 2018 | Pubmed ID: 29973539
Recalcitrant lip verrucous carcinoma successfully treated with acitretin after carbon dioxide laser ablation.
JAAD case reports Jul, 2018 | Pubmed ID: 29998178
Effects of 462 nm Light-Emitting Diode on the Inactivation of and a Multidrug-Resistant by Tetracycline Photoreaction.
Journal of clinical medicine Sep, 2018 | Pubmed ID: 30213146
Uroplakins play conserved roles in egg fertilization and acquired additional urothelial functions during mammalian divergence.
Molecular biology of the cell 12, 2018 | Pubmed ID: 30303751
Regeneration of rete ridges in Lanyu pig (Sus scrofa): Insights for human skin wound healing.
Experimental dermatology 04, 2019 | Pubmed ID: 30629757
Indocyanine Green-Mediated Photodynamic Therapy Reduces Methicillin-Resistant Drug Resistance.
Journal of clinical medicine Mar, 2019 | Pubmed ID: 30934605
Progenitor Cells Derived from Drain Waste Product of Open-Heart Surgery in Children.
Journal of clinical medicine Jul, 2019 | Pubmed ID: 31336927
Cystic Fibrosis Transmembrane Conductance Regulator: A Possible New Target for Photodynamic Therapy Enhances Wound Healing.
Advances in wound care Oct, 2019 | Pubmed ID: 31456905
Daylight Photodynamic Therapy: An Update.
Molecules (Basel, Switzerland) Nov, 2020 | Pubmed ID: 33171665
Optimize General Anesthesia for a Dystrophic Epidermolysis Bullosa Patient That Cannot Be Intubated.
Asian journal of anesthesiology 09, 2020 | Pubmed ID: 33176406
Transplantation of autologous single hair units heals chronic wounds in autosomal recessive dystrophic epidermolysis bullosa: A proof-of-concept study.
Journal of tissue viability Feb, 2021 | Pubmed ID: 33199167
Enhancing wound healing in recalcitrant leg ulcers with aminolevulinic acid-mediated antimicrobial photodynamic therapy.
Photodiagnosis and photodynamic therapy Mar, 2021 | Pubmed ID: 33346057
Real-world efficacy of biological agents in moderate-to-severe plaque psoriasis: An analysis of 75 patients in Taiwan.
PloS one , 2020 | Pubmed ID: 33373425
Recent Advances in Photodynamic Therapy for Deep-Seated Tumors with the Aid of Nanomedicine.
Biomedicines Jan, 2021 | Pubmed ID: 33445690
Effects of Solanum undatum extract (SR-T100) on photocarcinogenesis and photoaging of actinic keratosis.
The Journal of dermatology Mar, 2021 | Pubmed ID: 33458860
Imiquimod Accelerated Antitumor Response by Targeting Lysosome Adaptation in Skin Cancer Cells.
The Journal of investigative dermatology 09, 2021 | Pubmed ID: 33744296
Potential of Autologous Progenitor Cells and Decellularized Porcine Artery Matrix in Construction of Tissue-engineered Vascular Grafts.
Organogenesis 10, 2021 | Pubmed ID: 34405770
Microplasma Treatment versus Negative Pressure Therapy for Promoting Wound Healing in Diabetic Mice.
International journal of molecular sciences Sep, 2021 | Pubmed ID: 34638608
Repair of a Large Scrotal Skin Defect.
Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] Nov, 2021 | Pubmed ID: 34772829
Effects of free radicals from doxycycline hyclate and minocycline hydrochloride under blue light irradiation on the deactivation of Staphylococcus aureus, including a methicillin-resistant strain.
Journal of photochemistry and photobiology. B, Biology Jan, 2022 | Pubmed ID: 34864528
An AC electrokinetics-based electrochemical aptasensor for the rapid detection of microRNA-155.
Biosensors & bioelectronics Mar, 2022 | Pubmed ID: 34902642
Recent Advances in Photodynamic Therapy against Fungal Keratitis.
Pharmaceutics Nov, 2021 | Pubmed ID: 34959293
The Immunogenetics of Photodermatoses.
Advances in experimental medicine and biology , 2022 | Pubmed ID: 35286703
The Immunogenetic Aspects of Photodynamic Therapy.
Advances in experimental medicine and biology , 2022 | Pubmed ID: 35286707
International eDelphi Study to Reach Consensus on the Methotrexate Dosing Regimen in Patients With Psoriasis.
JAMA dermatology May, 2022 | Pubmed ID: 35353175
Extended-release tofacitinib for refractory Behçet disease: A case report.
Medicine Apr, 2022 | Pubmed ID: 35475806
Imiquimod-induced ROS production causes lysosomal membrane permeabilization and activates caspase-8-mediated apoptosis in skin cancer cells.
Journal of dermatological science Sep, 2022 | Pubmed ID: 36075780
Successful treatment of giant Bowen's disease with photodynamic therapy and subsequent imiquimod in a case with chronic arsenic exposure.
Photodiagnosis and photodynamic therapy Dec, 2022 | Pubmed ID: 36150635
The Association of Patent Ductus Arteriosus with Inflammation: A Narrative Review of the Role of Inflammatory Biomarkers and Treatment Strategy in Premature Infants.
International journal of molecular sciences Nov, 2022 | Pubmed ID: 36430355
An Update on Recent Advances of Photodynamic Therapy for Primary Cutaneous Lymphomas.
Pharmaceutics Apr, 2023 | Pubmed ID: 37242570
Cryosurgery provides a long-term disease-free survival in a patient with stage IIB acral lentiginous melanoma.
Asian journal of surgery Nov, 2023 | Pubmed ID: 37349174
Extended-Release Tofacitinib Therapy for a MDA5 Antibody-Positive Amyopathic Dermatomyositis Patient with Early-Stage Interstitial Lung Disease.
ImmunoTargets and therapy , 2023 | Pubmed ID: 38143567
TIMP3/Wnt axis regulates gliosis of Müller glia.
Biochimica et biophysica acta. Molecular basis of disease Feb, 2024 | Pubmed ID: 38369214
Photo-Responsive Ascorbic Acid-Modified AgS-ZnS Heteronanostructure Dropping pH to Trigger Synergistic Antibacterial and Bohr Effects for Accelerating Infected Wound Healing.
ACS applied materials & interfaces Mar, 2024 | Pubmed ID: 38394675
A point-of-care electrochemical biosensor for the rapid and sensitive detection of biomarkers in murine models with LPS-induced sepsis.
Biosensors & bioelectronics Mar, 2024 | Pubmed ID: 38489968
Cordycepin Inhibits Enterovirus A71 Replication and Protects Host Cell from Virus-Induced Cytotoxicity through Adenosine Action Pathway.
Viruses Feb, 2024 | Pubmed ID: 38543718
Jia-Horung Hung*,1,2,
Zhao-Xiang Wang*,3,4,
Yuan-Hsin Lo5,
Chaw-Ning Lee3,6,
Yun Chang7,
Rita Yuchiao Chang7,
Chien-Chun Huang3,
Tak-Wah Wong3,8,9
1Institute of Clinical Medicine, College of Medicine, National Cheng Kung University,
2Department of Ophthalmology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University,
3Department of Dermatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University,
4Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University,
5Department of Dermatology, Fu Jen Catholic University Hospital, Fu Jen Catholic University,
6Institute of Clinical Pharmacy and Pharmaceutical Sciences, College of Medicine, National Cheng Kung University,
7School of Medicine, National Cheng Kung University,
8Department of Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University,
9Center of Applied Nanomedicine, National Cheng Kung University
Cai-Ying Yang*,1,2,
Jia-Horung Hung*,3,
Chi-Jung Wu4,5,
Zhao-Xiang Wang1,2,
Shih-Han Wang6,
Hao-Chun Liaw2,
I-Huang Lin3,
Chun-Keung Yu1,6,
Tak-Wah Wong2,7,8
1Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University,
2Department of Dermatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University,
3Department of Ophthalmology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University,
4National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes,
5Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University,
6Insititute of Basic Medical Sciences, College of Medicine, National Cheng Kung University,
7Department of Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University,
8Center of Applied Nanomedicine, National Cheng Kung University
ABOUT JoVE
Copyright © 2024 MyJoVE Corporation. All rights reserved