mouse-model-of-oleic-acid-induced-acute-respiratory-distress-syndrome

Mouse Model of Oleic Acid-Induced Acute Respiratory Distress Syndrome

Acute respiratory distress syndrome (ARDS) is a significant threat to critically ill patients with a high fatality rate. Pollutant exposure, cigarette ...

Fundação Oswaldo Cruz, FIOCRUZ

Instituto Oswaldo Cruz, FIOCRUZ

Lung cancer is a leading cause of global cancer deaths. Na/K-ATPase has been studied as a target for cancer treatment. Cardiotonic steroids (CS) trigger intracellular signalling upon binding to Na/K-ATPase. Normal lung and tumour cells frequently express different pump isoforms. Thus, Na/K-ATPase is a powerful target for lung cancer treatment. Drugs targeting Na/K-ATPase may induce apoptosis and autophagy in transformed cells. We argue that Na/K-ATPase has a role as a potential target in chemotherapy in lung cancer treatment. We discuss the effects of Na/K-ATPase ligands and molecular pathways inducing deleterious effects on lung cancer cells, especially those leading to apoptosis and autophagy.

Adriana Ribeiro Silva

Laboratório de Imunofarmacologia

Fundação Oswaldo Cruz, FIOCRUZ

Mouse Model of Oleic Acid-Induced Acute Respiratory Distress Syndrome

Adriana Ribeiro Silva

.css-o250i3{font-size:18px;font-family:Open Sans,sans-serif;line-height:21.6px;}Laboratório de Imunofarmacologia

Fundação Oswaldo Cruz, FIOCRUZ

Mouse Model of Oleic Acid-Induced Acute Respiratory Distress Syndrome

Laboratório de Imunofarmacologia